Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism

Farina, Francesca R; Commins, Seán

doi:10.1016/j.bbr.2016.04.002

Cited by 22 publications

(25 citation statements)

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“…We then compared zif268 expression in the retrosplenial cortex and hippocampus after the rats had been tested with new extramaze cues and a mid‐trial rotation of the RAM as this procedure is considered particularly sensitive to retrosplenial cortex function (Pothuizen, Aggleton, & Vann, ; Vann &Aggleton, 2002; Vann, Wilton, Muir, & Aggleton, ). Zif268 was used because this marker is associated with spatial memory formation and long‐term plasticity whereas c‐Fos is a more general measure of neural activation (Farina & Commins, ; Jones et al, ; Penke et al, ). Naturally, postmortem clinical studies have not assessed IEG markers in cases of diencephalic amnesia.…”

Section: Introductionmentioning

confidence: 99%

Anterior thalamic nuclei lesions have a greater impact than mammillothalamic tract lesions on the extended hippocampal system

et al. 2017

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The anterior thalamic nuclei (ATN), mammillary bodies and their interconnecting fiber tract, the mammillothalamic tract (MTT), are important components of an extended hippocampal circuit for episodic memory. In humans, damage to the MTT or ATN in many disorders is associated with severe anterograde amnesia and it is assumed that their influence on memory is functionally equivalent. The relative influence of these two structures on memory has not, however, been assessed explicitly. Here, a direct comparison found that only ATN lesions impaired spatial reference memory in rats. ATN lesions produced more severe deficits on spatial working memory and reduced zif268 expression to a greater degree and in more corticolimbic sites than did MTT lesions. Conversely, MTT lesions reduced NeuN cell counts in all three subregions of the MB to a greater extent than did ATN lesions, so their relative impact cannot be explained by retrograde neuropathology of the MB. Hence ATN injury causes a more critical dysfunction than would be expected by an emphasis on the indirect influence of brainstem inputs to the extended memory system. The greater ATN lesion deficits found here may represent the consequence of disruption to the direct connections of the ATN with both hippocampal and cortical sites.

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Section: Introductionmentioning

confidence: 99%

Anterior thalamic nuclei lesions have a greater impact than mammillothalamic tract lesions on the extended hippocampal system

et al. 2017

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“…In addition, the mRNA and protein expressions of c-fos related genes, including c-jun, junB, and junD, increased when the LTP was induced [54–56]. zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with zif268 being more closely linked to spatial learning [57]. The Arc mRNA can be transported into the dendrites and generate cytoskeleton associated proteins in a few minutes after being highly stimulated, regulating the structural synaptic plasticity [58].…”

Section: Introductionmentioning

confidence: 99%

Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity

Wang¹,

Peng

2016

Military Med Res

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With key roles in essential brain functions ranging from the long-term potentiation (LTP) to synaptic plasticity, the N-methyl-D-aspartic acid receptor (NMDAR) can be considered as one of the fundamental glutamate receptors in the central nervous system. The role of NMDA R was first identified in synaptic plasticity and has been extensively studied. Some molecules, such as Ca2+, postsynaptic density 95 (PSD-95), calcium/calmodulin-dependent protein kinase II (CaMK II), protein kinase A (PKA), mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB), are of special importance in learning and memory. This review mainly focused on the new research of key molecules connected with learning and memory, which played important roles in the NMDAR signaling pathway.

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“…We also explored the effects of NMDA receptor blockade on spatial and non‐spatial memory retrieval. NMDA receptor activation has been shown to be heavily involved in spatial learning (Farina & Commins, 2016; Morris et al., 1986). Importantly, recent evidence suggests that NMDA blockade is the primary cause of spatial deficits (Morris, Steele, Bell, & Martin, 2013), as opposed to being secondary to sensorimotor deficits caused by NMDA antagonism (previously suggested by Cain, Saucier, Hall, Hargreaves, & Boon, 1996).…”

Section: Discussionmentioning

confidence: 99%

Hippocampal and prefrontal contributions to memory retrieval: Examination of immediate early gene, NMDA receptor and environmental interactions

Farina

Commins

2020

Eur J of Neuroscience

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Animals can use a range of strategies to recall important locations. These include simple stimulus–response strategies and more complex spatial (place) strategies, which are thought to have distinct neural substrates. The hippocampus—and NMDA receptor activation therein—is considered to be crucial for spatial, but not response strategies. The medial prefrontal cortex has also been implicated in memory retrieval; however, evidence concerning its specific role is equivocal. Both hippocampal and prefrontal regions have been associated with flexible behavioural responding (e.g. when task demands change). Here, we investigated the use of spatial and non‐spatial strategies in the Morris water maze and their associated brain areas in rats using immediate early gene (IEG) imaging of Zif268 and c‐Fos. Specifically, we charted the involvement of hippocampal and prefrontal subregions during retrieval of spatial and non‐spatial memories. Behavioural flexibility was also examined using intact and partial cue configurations during recall. Results indicated that regions of both the hippocampus (area CA3) and prefrontal cortex (anterior cingulate cortex) were preferentially engaged in spatial memory recall compared to response learning. In addition, both spatial and non‐spatial memories were dependent on NMDA receptor activation. MK801 impaired recall performance across all groups and reduced IEG activation across hippocampal and prefrontal regions. Finally, IEG results revealed divergent patterns of Zif268 and c‐Fos activity and support the suggestion that Zif268 plays a functional role in the recall of long‐term memories.

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Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism

Cited by 22 publications

References 20 publications

Anterior thalamic nuclei lesions have a greater impact than mammillothalamic tract lesions on the extended hippocampal system

Anterior thalamic nuclei lesions have a greater impact than mammillothalamic tract lesions on the extended hippocampal system

Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity

Hippocampal and prefrontal contributions to memory retrieval: Examination of immediate early gene, NMDA receptor and environmental interactions

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