Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas

Abstract

The genetic events involved in thyroid carcinogenesis are still incompletely understood. Several rearrangements and mutations of oncogenes have been implicated in the development of thyroid papillary carcinomas, follicular adenomas and carcinomas. However, none of these molecular alterations is suitable either as a general marker for the diagnosis of thyroid carcinomas or to differentiate between thyroid follicular adenomas and carcinomas. In order to identify new genes with altered expression which could serve as such markers, we analyzed RNA from thyroid tumor and normal tissue using a novel technique called restriction-mediated differential display. Several differentially expressed genes were identified, including the gene for IgG Fc binding protein (Fc BP). Differential expression of Fc BP was confirmed by quantitative realtime RT-PCR. Our experiments showed that IgG Fc binding protein (Fc BP) is differentially expressed in normal thyroid tissue, thyroid adenomas and thyroid carcinomas. While the Fc BP gene is constitutively expressed in normal thyroid tissue, its expression is significantly increased in follicular thyroid adenomas and significantly decreased in papillary and follicular thyroid carcinomas. Thus, measurement of the expression levels of Fc BP in thyroid biopsies might help to make the otherwise difficult distinction between a thyroid follicular adenoma and a follicular carcinoma.

Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer

“…Note, recently its association with cancer has been reported in that FcgBP expression was significantly reduced in papillary and follicular thyroid carcinoma. 4 Abundance of FcgBP in bowel lumen and respiratory tract with mucus suggests that it might be involved in anti-inflammation. 17 Epidemiological association between prostatitis and prostate cancer has been documented.…”

“…Recently, down regulation of the FcgBP gene in thyroid carcinoma has been reported. 4 Prostate cancer is the most frequently occurring endocrine tumors and the second most common cause of cancer-related death in men in western countries. It is estimated that there will be around 27,000 of prostate cancer deaths in the year 2007.…”

Comparison of the Gene Expression Profiles Between Smokers With and Without Lung Cancer Using RNA-Seq

“…IgG Fc binding protein (FcγBP) that binds the Fc portion of IgG molecules has been reported in mucin secreting cells in colon, small intestine, gall bladder, cystic duct, bronchus, sub mandibullar gland, cervix uteri, and in fluids secreted by these cells in human (O'Donovan et al, 2002). The FcγBP gene investigated in the study has potential as a genetic marker in lung cancer.…”

Copy number variation analysis reveals additional variants contributing to endometriosis development

“…According to the UCSC Genome Browser and Database of Genomic Variants [25,26], this duplicated region is located within the FCGBP gene. Characterized by the production of a large (encoded by a 17-kb mRNA) mucin-like protein that binds the Fc portion of IgG molecules, this gene has been reported as differentially expressed in gallbladder [45], prostate [46], thyroid [47], lung [48], colon [49], and ovarian cancer [50]. Present in serum, the protein can be found in higher levels in patients with autoimmune diseases [51].…”