Differential expression of heat shock protein genes associated with heat stress in Nelore and Caracu beef cattle

“…McManus et al (2002) showed that locally adapted Pantaneiro cattle had approximately twofold the reproduction rate of Nelore cattle in the environment found in the Brazilian Pantanal. Nelore is considered a thermotolerant breed (Pires et al, 2019); nevertheless, Mattar et al (2011) showed that phenotype plasticity and genotype expression may be changed along the environmental gradient through selection. In the United States, Blackburn et al (2017) found ecoregion differences in allele frequencies, mainly between arid and humid regions.…”

Section: Resultsmentioning

confidence: 99%

Bovine landscape genetics in Brazil

Souza

Egito

Peripolli

et al. 2022

Sci. agric. (Piracicaba, Braz.)

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“…In their GWAS, they identified genes that are related to the triggering of inflammatory response [ 9 , 11 ] and belong to the HSP (heat shock protein) gene family [ 10 , 11 , 41 ], which can also modulate stress response, inflammatory response as well as the levels of glucose and fatty acids [ 42 ], and the fertilization and preimplantation of embryos [ 43 ]. Elevated levels of cortisol induce the synthesis of HSP to trigger stress response and cellular adaptation [ 44 – 46 ]. The INDEL variant on the MC2R gene could affect the stability of the transcribed mRNA, affecting the expression of the ACTH receptor that modulates the cortisol response.…”

Section: Discussionmentioning

confidence: 99%

Selection for environmental variance of litter size in rabbits involves genes in pathways controlling animal resilience

et al. 2021

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Background Environmental variance (VE) is partially under genetic control, which means that the VE of individuals that share the same environment can differ because they have different genotypes. Previously, a divergent selection experiment for VE of litter size (LS) during 13 generations in rabbit yielded a successful response and revealed differences in resilience between the divergent lines. The aim of the current study was to identify signatures of selection in these divergent lines to better understand the molecular mechanisms and pathways that control VE of LS and animal resilience. Three methods (FST, ROH and varLD) were used to identify signatures of selection in a set of 473 genotypes from these rabbit lines (377) and a base population (96). A whole-genome sequencing (WGS) analysis was performed on 54 animals to detect genes with functional mutations. Results By combining signatures of selection and WGS data, we detected 373 genes with functional mutations in their transcription units, among which 111 had functions related to the immune system, stress response, reproduction and embryo development, and/or carbohydrate and lipid metabolism. The genes TTC23L, FBXL20, GHDC, ENSOCUG00000031631, SLC18A1, CD300LG, MC2R, and ENSOCUG00000006264 were particularly relevant, since each one carried a functional mutation that was fixed in one of the rabbit lines and absent in the other line. In the 3ʹUTR region of the MC2R and ENSOCUG00000006264 genes, we detected a novel insertion/deletion (INDEL) variant. Conclusions Our findings provide further evidence in favour of VE as a measure of animal resilience. Signatures of selection were identified for VE of LS in genes that have a functional mutation in their transcription units and are mostly implicated in the immune response and stress response pathways. However, the real implications of these genes for VE and animal resilience will need to be assessed through functional analyses.

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Differential expression of heat shock protein genes associated with heat stress in Nelore and Caracu beef cattle

Cited by 27 publications

References 31 publications

Liver fatty acid metabolism associations with reproductive performance of dairy cattle

Liver fatty acid metabolism associations with reproductive performance of dairy cattle

Bovine landscape genetics in Brazil

Selection for environmental variance of litter size in rabbits involves genes in pathways controlling animal resilience

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