Abstract:Myogenesis involves the fusion of myoblasts into myotubes. Mitochondrial biogenesis plays an important role in myogenesis, but the molecular mechanisms that govern the changes in mitochondria during differentiation have yet to be fully elucidated. Thus, we sought to describe the regulation of mitochondrial biogenesis during 8 days of C2C12 myoblast differentiation in culture. Cytochrome c oxidase (COX) activity, a marker of biogenesis, was increased by 2.6‐fold during differentiation. The mRNAs encoding the fu… Show more
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