Differential Expression of Endogenous Retroviruses and Inflammatory Mediators in Female and Male Offspring in a Mouse Model of Maternal Immune Activation

Cipriani, C.; Tartaglione, Anna Maria; Giudice, Martina; D’Avorio, Erica; Petrone, Vita; Toschi, Nicola; Chiarotti, Flavia; Miele, Martino Tony; Calamandrei, Gemma; Garaci, Enrico; Matteucci, Claudia; Vallebona, P Sinibaldi; Ricceri, Laura; Balestrieri, Emanuela

doi:10.3390/ijms232213930

Cited by 3 publications

(4 citation statements)

References 78 publications

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“…Specifically, we demonstrated that the prenatal exposure to Poly I:C in C57BL6/J mice induced a tissue-specific expression of several ERVs, ERV-related genes and inflammatory mediators with ERVs as the main carriers of the peculiar profile found in brain areas from Poly I:C mice. In addition, Poly I:C induced larger effects on the expression of some retroviral elements only in pre-frontal cortex from female offspring reinforcing the view on sex bias as a possible risk factor for ASD [136].…”

Section: Human Endogenous Retroviruses In Neurodevelopmental Disordersmentioning

confidence: 61%

Human Endogenous Retroviruses in Autism Spectrum Disorders: Recent Advances and New Perspectives at the Gene-Environment Interface

Balestrieri¹,

Cipriani²,

Garaci³

et al. 2023

Autism Spectrum Disorders - Recent Advances and New Perspectives

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Human endogenous retroviruses (HERVs) are genetic elements, derived from their exogenous retroviral counterpart by a process of germline infection and proliferation within the human genome, and their integration as proviruses led to the fixation and the vertical transmission, following Mendelian laws. HERVs currently make up ~8% of the genetic material, and some of them have been cooped for physiological functions. Otherwise, their activation in response to environmental factors has been associated with human pathological conditions. In the setting of neurodevelopmental disorders, HERVs have been proposed as contributing factors involved in Autism Spectrum Disorders (ASD), spanning the bridge between genetic susceptibility, environmental risk factors and immune response. We described a distinct expression profile of some HERV families and cytokines in lymphocytes from autistic children and in their mothers suggesting a close mother-child association in ASD. Moreover, in vitro treatment with an antiretroviral drug was able to restore the expression level of HERVs and cytokines providing new insights into the potential role of HERVs as biomarkers of ASD and raising the possibility of using HERVs expression as a therapeutic target for a tailored approach to patient care.

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Section: Human Endogenous Retroviruses In Neurodevelopmental Disordersmentioning

confidence: 61%

Human Endogenous Retroviruses in Autism Spectrum Disorders: Recent Advances and New Perspectives at the Gene-Environment Interface

Balestrieri¹,

Cipriani²,

Garaci³

et al. 2023

Autism Spectrum Disorders - Recent Advances and New Perspectives

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“…Researchers investigate how maternal immune activation affects fetal brain development and whether this impact is related to ASD ( 75 ). Specifically, this context has piqued interest in inflammation-related cytokines and immune molecules ( 76 , 77 ). Recent research suggests that the relationship between maternal immune activation and ASD may involve interactions between genetics and the environment.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of autism spectrum disorder signaling pathways research in the past decade

Lyu,

Li,

Chen

et al. 2024

Front. Psychiatry

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BackgroundThis study employs bibliometric methods to comprehensively understand the fundamental structure of research about Autism Spectrum Disorder (ASD) Signaling Pathways by examining key indicators such as nations, institutions, journals, authors, and keywords.MethodologyWe utilized the WoScc database to retrieve literature relevant to ASD Signaling Pathways published between 2013 and 2023. Through visual analysis and tools like CiteSpace and VosViewer, we explored nations, institutions, journals, authors, and keywords, thereby constructing relevant networks.Results26 The study encompasses 1,396 articles, revealing a consistent increase in publications. The United States, China, and Germany are leading nations in this literature. Regarding research institutions, the University of California system and Eric Klann have garnered significant attention due to their substantial contributions to the field of ASD Signaling Pathways. Most relevant research is published in the journal “Molecular Autism.” Research interests are concentrated across various themes, including “elevating neuronal β-catenin levels,” “Tunisian children,” “Fmr1 knockout (KO) mice,” “de novo mutations,” “autistic children,” “local translation,” “propionic acid-induced mouse models,” “neurosystems,” “glucose metabolism,” and “neuronal migration.” Future research may emphasize exploring aspects such as gut microbiota, genes, stress, maternal immune activation, memory, and neurodevelopmental disorders of ASD.ConclusionThis study, through bibliometric analysis of key indicators such as nations, institutions, journals, authors, and keywords, provides a comprehensive overview of the current state of research on ASD Signaling Pathways. These investigations predominantly focus on molecular mechanisms, animal model studies, population-based research, and the structure and function of neurosystems. Future research directions are also clearly proposed. First, in-depth research on the genes and neurodevelopmental disorders associated with ASD will continue to reveal the genetic basis and provide support for precise treatments. At the same time, attention to the gut microbiota will help explore its association with ASD, which may provide clues for new treatments. In addition, the relationship between stress and ASD will become the focus of research to understand better the emotional and behavioral characteristics of ASD patients in stressful situations. Maternal immune activation will also be further studied to explore how environmental factors influence the risk and development of ASD. Finally, a deeper understanding of the cognitive functions of patients with ASD, especially memory and learning, will help develop individualized treatment strategies to improve patients’ quality of life. These directions will work together and are expected to provide a more comprehensive understanding of Signaling Pathways research in ASD and provide new ideas and opportunities for future intervention and treatment.

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“…Type I interferons are crucial in the innate immune response to HERVs. They are produced in response to recognizing HERV-derived single-stranded RNA (ssRNA) or dsRNA by PRRs [59][60][61]. These interferons inhibit HERV replication and expression, thereby limiting their activity.…”

Section: Interaction Between Herv and The Innate Immune Systemmentioning

confidence: 99%

“…Prostate cancer -HERVs could potentially serve as diagnostic or prognostic biomarkers for prostate cancer due to antibody response [61,123].…”

Section: Melanomamentioning

confidence: 99%

Exploring HERV-K (HML-2) Influence in Cancer and Prospects for Therapeutic Interventions

Costa,

Vale

2023

IJMS

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This review investigates the intricate role of human endogenous retroviruses (HERVs) in cancer development and progression, explicitly focusing on HERV-K (HML-2). This paper sheds light on the latest research advancements and potential treatment strategies by examining the historical context of HERVs and their involvement in critical biological processes such as embryonic development, immune response, and disease progression. This review covers computational modeling for drug-target binding assessment, systems biology modeling for simulating HERV-K viral cargo dynamics, and using antiviral drugs to combat HERV-induced diseases. The findings presented in this review contribute to our understanding of HERV-mediated disease mechanisms and provide insights into future therapeutic approaches. They emphasize why HERV-K holds significant promise as a biomarker and a target.

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Differential Expression of Endogenous Retroviruses and Inflammatory Mediators in Female and Male Offspring in a Mouse Model of Maternal Immune Activation

Cited by 3 publications

References 78 publications

Human Endogenous Retroviruses in Autism Spectrum Disorders: Recent Advances and New Perspectives at the Gene-Environment Interface

Human Endogenous Retroviruses in Autism Spectrum Disorders: Recent Advances and New Perspectives at the Gene-Environment Interface

A bibliometric analysis of autism spectrum disorder signaling pathways research in the past decade

Exploring HERV-K (HML-2) Influence in Cancer and Prospects for Therapeutic Interventions

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