Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stroma

Nakayama, Hirofumi; Enzan, Hideaki; Miyazaki, Eriko; Kuroda, Naoto; Naruse, Keishi; Hiroi, Makoto

doi:10.1136/jcp.53.8.626

Cited by 70 publications

(76 citation statements)

References 17 publications

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“…Also, Kuroda et al (2004) studied the CD34-positive cells diffusion in intestinal tumors and concluded that stromal cells of CD34-positive, present in the area between sub-mucosal and sub-serous of normal tissue, were removed from this region after tumor invasion and were transferred to deeper layers of tumors. The results were confirmed in another study that showed the inflamed tissue in tumor margins and tumor stroma of stromal cells are free of CD34 (Nakayama et al, 2000).…”

Section: Discussionsupporting

confidence: 74%

“…In moderately differentiated tumors, CD34 expression was significantly lower than less differentiated cancers and CD34 expression in diffuse type was more than intestinal one. Similar results were reported on the positive relationship between this marker and differentiation and tumor type on the intestinal adenocarcinoma in numerous studies (Choi et al, 2009;Feng et al, 2010;Nakayama et al, 2000). Although, the depth of invasion was not significantly different from marker expression but the difference was too much, so that 87.5% of positive cases had a depth of T3 that of all tumors in depth of T3, a quarter of them have expressed a marker.…”

Section: Discussionsupporting

confidence: 72%

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Correlation between CD34 Marker and Clinico-Pathologic Characteristics of Gastric Cancer

Habibi¹,

Ranjbari²,

Rahim³

et al. 2015

International J. of Cancer Research

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One of the most common cancers in the world, especially in underdeveloped countries, is Gastric Cancer (GC) which kills thousands of people annually. It is also prevalent in our country, Iran and according to statistics, it is the most common cancer in men. Since, the relationship between expression of CD34 cell surface markers and many cancers has been approved in the present study, the marker expression association with GC is studied. In this study, a total of 47 paraffin blocks of patients with GC referring to Imam Khomeini hospital in Ahvaz, during 2003-2013 were used. The mean age of 47 patients, including, 35 men (74.5%) and 12 women, was 60±16.05 years old ranging from 24-84. The mean tumor size was 34.5 ranging from 2-12 cm. More than 71% of tumors were intestinal type and the depth of more than 74% of them was in T3 phase. Incidence of marker was positive in only 8 patients (17%) and in rest 39 was negative. The CD34 expression was significantly correlated only with the tumor type (p = 0.00), degree of malignancy (p = 0.00) and neural invasion (p = 0.01). In this study, a positive correlation was observed between the marker expression and three factors of tumor type, degree of differentiation and neural invasion. It was also concluded that due to the negative CD34 expression in 83% of samples, the absence of positive CD34 cells in tumor tissue can be considered as a marker in GC, although it is recommended to do further research with more samples in this context.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 72%

Correlation between CD34 Marker and Clinico-Pathologic Characteristics of Gastric Cancer

Habibi¹,

Ranjbari²,

Rahim³

et al. 2015

International J. of Cancer Research

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“…+ fibrocytes (CD34 is a 110 kDa surface antigen selectively expressed on human haematopoietic progenitor cells) originating from myeloid precursors in the bone marrow were considered as a source of myofibroblasts in cancer of the colon [129], pancreas, [130], and breast [131]. Experimental studies have shown that CD34 + fibrocytes are attracted by the secondary lymphoid chemokine CCL-21, a ligand of the CCR7 chemokine receptor, and invade sites of tissue damage in vivo.…”

Section: The Origin Of Myofibroblastsmentioning

confidence: 99%

Role of tissue stroma in cancer cell invasion

Wever

Mareel

2003

The Journal of Pathology

927

813

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“…They added that using CD34 immunohistochemistry may be useful in detecting large neoplasms. In another study, it was shown that most stromal cells are CD34+in the sub-mucosal, muscularis propria and suborosa as well as normal perirectal tissues, while the inflamed tissues around tumor and tumor stroma of stromal cells lacked CD34 (Nakayama et al, 2000). The study findings showed that lack of CD34 expression of stromal cells in colorectal adenocarcinoma is involved in creation of a desmoplastic reaction.…”

Section: Discussionmentioning

confidence: 76%

“…Another study examined the immunohistochemical analysis of CD34 in colorectal cancer, colorectal adenomas and colorectal non-neoplastic lesions. In this study, the expression of CD34 was associated with recurrence, metastasis and survival of colorectal malignancies and this indicated the prognostic role of CD34 in colorectal cancer (Nakayama et al, 2000). Liang et al (2004) used the immunohistochemical expression of CD34 as a marker for the diagnosis and assessment of MicroVessel Density (MVD) and its association with the capillary development in colon cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Expression of CD34 Marker in Colorectal Adenocarcinoma and its Relationship with Clinicopathologic Factors

Behbehani¹,

Ranjbari²,

Rahim³

et al. 2015

Asian J. of Cell Biology

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Colorectal cancer is known as one of the most common types of cancer which the prevalence is increasing. According to reports, malignancies of the large intestine have highly broken out in Iran. Several studies have shown the correlation between the CD34 cell surface markers and some cancers. In the present study, the relationship between the protein expression and clinico-pathologic characteristics was evaluated. In this study, 40 paraffin blocks belonged to patients with colorectal cancer referring to Imam Khomeini Hospital in Ahvaz during [2003][2004][2005][2006][2007][2008][2009][2010][2011][2012][2013] were studied by immunohistochemistry method. From 40 samples, 22 were males and 18 females. Their mean age was 56±17.9 years and ranging from 22-87 years. The mean tumor size was 5.1 cm ranging 11-1.5 cm. The most common site of involvement was in the right colon (45%) and the rarest site in the transverse colon (10%) and 75% was in poorly-differentiated state in terms of tumor grade. Generally, marker expression was positive in 13 cases and negative in 27 cases. The CD34 expression was significantly correlated with tumor size, tumor depth, degree of differentiation as well as lymphatic, vascular and neural invasions. A positive correlation was observed between the marker expression and pathological characteristics. Therefore, CD34 marker expression can be effective as a marker in the diagnosis of pathological characteristics of colorectal cancer. However, further studies with a large population are recommended.

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Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stroma

Cited by 70 publications

References 17 publications

Correlation between CD34 Marker and Clinico-Pathologic Characteristics of Gastric Cancer

Correlation between CD34 Marker and Clinico-Pathologic Characteristics of Gastric Cancer

Role of tissue stroma in cancer cell invasion

Evaluating the Expression of CD34 Marker in Colorectal Adenocarcinoma and its Relationship with Clinicopathologic Factors

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