Differential expression of CCL18 in moderate/severe and mild persistent allergic rhinitis and its correlation with disease parameters

Pirayesh, Ashkan; Ferdosi, Samira; Shirzad, Hedayatollah; Amani, Soroush; chegini, hajar bahadivand; Bagheri, Nader; Sadeghian, Ladan; Torkamand, Farbod

doi:10.1080/15321819.2018.1506931

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…CC chemokine ligand 18 (CCL18) is a CC chemokine constitutively highly expressed in human lung and plasma and upregulated during inflammatory and cancer processes in many organs [ 23 ]. It was found to be elevated in bronchoalveolar lavage and serum from allergic asthmatic patients [ 24 ] and in many allergic conditions, such as atopic dermatitis and allergic rhinitis [ 25 , 26 , 27 ]. CCL18 exhibits chemotactic activity toward human naive T cells [ 28 ], skin-homing memory T cells [ 25 ], B lymphocytes [ 29 ], immature DC [ 30 ], Th2 cells [ 24 ], basophils [ 24 ], regulatory T cells [ 31 ], and NK cells [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Killer Cells from Allergic Donors Are Defective in Their Response to CCL18 Chemokine

Amniai

Plé

Barrier

et al. 2021

IJMS

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Natural killer (NK) cells were originally described as cytolytic effector cells, but since then have been recognized to possess regulatory functions on immune responses. Chemokines locate NK cells throughout the body in homeostatic and pathological conditions. They may also directly stimulate immune cells. CCL18 is a constitutive and inducible chemokine involved in allergic diseases. The aim of this study was to evaluate CCL18’s effect on NK cells from allergic and nonallergic donors in terms of both chemotactic and immune effects. Results showed that CCL18 was able to induce migration of NK cells from nonallergic donors in a G-protein-dependent manner, suggesting the involvement of a classical chemokine receptor from the family of seven-transmembrane domain G-protein-coupled receptors. In contrast, NK cells from allergic patients were unresponsive. Similarly, CCL18 was able to induce NK cell cytotoxicity only in nonallergic subjects. Purified NK cells did not express CCR8, one of the receptors described to be involved in CCL18 functions. Finally, the defect in CCL18 response by NK cells from allergic patients was unrelated to a defect in CCL18 binding to NK cells. Overall, our results suggest that some NK cell functions may be defective in allergic diseases.

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Section: Introductionmentioning

confidence: 99%

Natural Killer Cells from Allergic Donors Are Defective in Their Response to CCL18 Chemokine

Amniai

Plé

Barrier

et al. 2021

IJMS

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“…As an IgE-mediated immunologic disease, allergic rhinitis (AR) is associated with nasal symptoms such as sneezing, rhinorrhea, and congestion against inhaled allergens, and its histological features include mucosal inflammation driven by type 2 helper T (Th2) cells. [1][2][3][4][5] AR is the most frequent chronic diseases observed in children. 5,6 In addition to high medical cost, it is coupled with life quality reduction, lower work production, and low academic performance at school.…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of Fas in Moderate/Severe and Mild Persistent Allergic Rhinitis and Its Correlation With Pathological Parameters

Pirayesh

Shahsavan

Samani

et al. 2019

Am J Rhinol�Allergy

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Background and Aims The roles of Fas in immune system are multifaceted, and the interaction between Fas receptor and Fas ligand is essential for maintaining the immune tolerance. We aimed to assess the level of the expression of Fas receptor on nasal inferior turbinate mucosa in patients with mild persistent allergic rhinitis (M PAR) and moderate to severe (M/S) PAR and determined the relationship between disease severity and production of Fas. Methods A total of 70 patients with M/S PAR, 70 patients with M PAR, and 70 healthy individuals were enrolled in this study. We obtained biopsies of nasal inferior turbinate mucosa from the participants. The expression of Fas mRNA was evaluated by real-time polymerase chain reaction. The presence and location of Fas were determined by immunohistochemistry. The number of eosinophils per field, blood eosinophils, total serum IgE levels, and specific serum IgE levels were measured. Clinical manifestations of patients were assessed by Total Nasal Syndrome Score (TNSS). Results The expression of Fas in patients with M/S PAR was decreased significantly compared to the control group and patients with M PAR. Local mucosal expression of Fas was correlated with specific IgE, nasal eosinophil count, and TNSS. Conclusion According to the results of this study, there might be a relationship between the expression of Fas receptor on nasal turbinate mucosa and the severity of persistent allergic rhinitis.

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Chemokines and chemokine receptors in allergic rhinitis: from mediators to potential therapeutic targets

Jiang

et al. 2022

Eur Arch Otorhinolaryngol

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Differential expression of CCL18 in moderate/severe and mild persistent allergic rhinitis and its correlation with disease parameters

Abstract: The results of the study indicate that there could be a relationship between the expression of CCL-18 in nasal turbinate mucosa and the severity of allergic rhinitis.

Cited by 5 publications

References 21 publications

Natural Killer Cells from Allergic Donors Are Defective in Their Response to CCL18 Chemokine

Natural Killer Cells from Allergic Donors Are Defective in Their Response to CCL18 Chemokine

Differential Expression of Fas in Moderate/Severe and Mild Persistent Allergic Rhinitis and Its Correlation With Pathological Parameters

Chemokines and chemokine receptors in allergic rhinitis: from mediators to potential therapeutic targets

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