Differential expression and prognostic value of long non‐coding RNA in HPV‐negative head and neck squamous cell carcinoma

Haque, Sulsal; Niu, Liang; Kuhnell, Damaris; Hendershot, Jacob; Biesiada, Jacek; Niu, Wen; Hagan, Matthew; Kelsey, Karl T.; Casper, Keith; Wise‐Draper, Trisha M.; Medvedovic, Mario; Langevin, Scott M.

doi:10.1002/hed.25136

Cited by 31 publications

(34 citation statements)

References 37 publications

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“…To date, high linc00152 levels have been detected in many cancers, and the associated mechanisms mediating tumorigenesis are complex and specific. Deregulated linc00152 expression has been observed in head and neck squamous cell carcinoma, in which five types of lncRNAs, including linc00152, are differentially expressed . A previous study by Chen et al involving an analysis of 60 lung cancer tissues by RT‐PCR revealed that linc00152 is expressed significantly more in lung cancer tissue than in normal lung tissue.…”

Section: Molecular Functions and Mechanisms Of Linc00152 In Human Tumorsmentioning

confidence: 99%

“…To date, high linc00152 levels have been detected in many cancers, [21][22][23] and the associated mechanisms mediating tumorigenesis are complex and specific. Deregulated linc00152 expression has been observed in head and neck squamous cell carcinoma, in which five types of lncRNAs, including linc00152, are differentially expressed.…”

Section: Overexpression Of Linc00152 Enhances Cell Proliferation Imentioning

confidence: 99%

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Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Guo

Jiang

et al. 2019

Cancer Medicine

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Linc00152, located on chromosome 2p11.2, is a long intergenic non‐coding RNA molecule with 828 nucleotides that is highly expressed in many types of human tumor tissues, especially in malignant tumors of the digestive system. Linc00152 promotes the occurrence and development of tumors by increasing tumor cell proliferation, invasion, metastasis, and apoptosis. Additionally, linc00152 contributes to the carcinogenesis of several cancers, including gastric cancer, liver cancer, hepatocellular carcinoma, gallbladder cancer, clear cell renal cell carcinoma, and colorectal cancer, by disturbing various signaling pathways (eg PI3K/AKT, mTOR, IL‐1, and NOTCH 1 signaling pathways). High linc00152 expression levels are associated with chemoresistance as well as poor prognosis and shorter survival. Continual advances made in the relevant research have indicated that linc00152 may be useful as a new tumor molecular biomarker, applicable for tumor diagnosis, targeted therapy, and prognosis assessment. This review summarizes the progress in the research into the relationship between linc00152 and the occurrence and development of malignancies based on molecular functions, regulatory mechanisms, and clinical applications.

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Section: Molecular Functions and Mechanisms Of Linc00152 In Human Tumorsmentioning

confidence: 99%

Section: Overexpression Of Linc00152 Enhances Cell Proliferation Imentioning

confidence: 99%

Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Guo

Jiang

et al. 2019

Cancer Medicine

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“…Notably, long intergenic non-coding RNA 00152 (LINC00152) has been reported to be increased in numerous types of cancer, including glioblastoma, ovarian cancer, urothelial bladder carcinoma and breast cancer (21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA LINC00152 acts as a sponge of miRNA‑193b‑3p to promote tongue squamous cell carcinoma progression

Rui

Cao

et al. 2020

Oncol Lett

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Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 00152 (LINC00152) expression was significantly increased in human TSCC tissues compared with in tissues from matched controls using RT-qPCR. In TSCC cell lines, CAL-27 and SCC-9, LINC00152 was revealed to promote TSCC cell proliferation, enhance cell cycle progression and inhibit cell apoptosis. Additionally, migration and invasion of TSCC cell lines was increased in response to LINC00152 overexpression. Mechanistically, LINC00152 was determined to be localized in the cytoplasm and acted as a microRNA (miR)-193b-3p sponge, and LINC00152 knockdown or miR-193b-3p mimics both inhibited PI3K signaling pathway activation and downstream AKT phosphorylation; therefore, promoting TSCC progression in vitro. Overall, the results of the present study suggested that increased LINC00152 expression in TSCC tissues may act as a sponge of miR-193b-3p to promote cancer progression in vitro.

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“…19 It is therefore of interest to ascertain what effects, if any, HPV infection may have upon lncRNAs in HNSCC that could explain the differential prognoses. While previous studies have analyzed differential expression of lncRNA in HNSCC, 20 showed significant negative correlation with lnc-IL17RA-11 but differential expression was not significant (|log2 FC| < 1; P-adj > 0.01). ESR1 exhibited positive correlation (cor = 0.1998, P-adj = 3.63e−05) and E) significant differential expression (|log2 FC| = 1.8067, P-adj = 6.06e-24).…”

Section: Genes Coexpressed With Lncrnas In Hnsccmentioning

confidence: 70%

Association of lnc‐IL17RA‐11 with increased radiation sensitivity and improved prognosis of HPV‐positive HNSCC

Song

Xie

Tong

et al. 2019

J of Cellular Biochemistry

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Human papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a far better prognosis than HPV negative HNSCC. Recent studies suggest that long noncoding RNA (lncRNA) moieties may play a role in HPV associated differential HNSCC prognoses. In this study, we examined differential expression of lncRNAs in HPV+ vs HPV− HNSCC using The Cancer Genome Atlas database. LncRNAs were categorized based on expression level and survival analysis. A group of eight lncRNAs was identified in which altered expression was associated with both HPV infection and better prognosis. Subsequently, genes coexpressed with these lncRNAs in HNSCC cells were sorted into corresponding co‐expression modules. The lnc‐IL17RA‐11 coexpression module exhibited the greatest correlation with HPV infection and radiotherapy efficacy. We identified the lnc‐IL17RA‐11 transcription factor ER‐alpha as the most likely HPV infection associated factor promoting increased lnc‐IL17RA‐11 levels. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis revealed enrichment among lnc‐IL17RA‐11 co‐expressed genes for functions related to DNA replication and cell proliferation. These observations are consistent with a model in which HPV infection upregulates transcription factor ER‐alpha, which increases levels of lnc‐IL17RA‐11 and coexpressed genes that promote HNSCC cell sensitivity to radiotherapy, thereby improving disease prognosis.

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Differential expression and prognostic value of long non‐coding RNA in HPV‐negative head and neck squamous cell carcinoma

Abstract: We identified and validated differential expression of 5 lncRNA in HPV-negative HNSCC. Low MEG3 expression was associated with favorable 3-year RFS, although the significance of this finding remains unclear.

Cited by 31 publications

References 37 publications

Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Long non‑coding RNA LINC00152 acts as a sponge of miRNA‑193b‑3p to promote tongue squamous cell carcinoma progression

Association of lnc‐IL17RA‐11 with increased radiation sensitivity and improved prognosis of HPV‐positive HNSCC

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