Differential ex vivo drug resistance profile in first and subsequent relapsed childhood acute myeloid leukemia in comparison to initial diagnosis

Kuryło-Rafińska, Beata; Kołodziej, Beata; Kubicka, Małgorzata; Wysocki, Mariusz; Styczyński, Jan

doi:10.2478/v10251-012-0027-5

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2014

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“…Cellular drug resistance is one of the main causes of the frequent ultimate failure of chemotherapy in childhood acute leukemias [10], especially on relapse [11][12]. Current concepts suggest that drug resistance is related to the presence of leukemic stem cells [13][14].…”

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confidence: 99%

In Vitro Drug Resistance in Childhood Mature B-Cell Acute Lymphoblastic Leukemia

Wiśniewska

Styczyński

Czyżewski

et al. 2014

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B a c k g r o u n d. Mature B-cell acute lymphoblastic leukemia (B-ALL) is a rare type of leukemia in children and counts for 1-2% of all leukemia cases. Pediatric BALL is treated according to protocols for non-Hodgkin lymphomas. O b j e c t i v e. The aim of the study was to analyze the in vitro drug resistance in children with BALL compared to ALL with other phenotypes. M a t e r i a l a n d m e t h o d s. A total number of 15 children with BALL (6 girls and 9 boys, median age 8 years, range 1.9-15 years) were included into the analysis. The in vitro drug resistance tests on leukemic cells were performed by means of the MTT assay. The results of BALL patients were compared to those obtained in patients with pre

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