Differential epigenetic profiles induced by sodium selenite in breast cancer cells

Liang, Zhuo-Zhi; Zhu, Rui-Mei; Li, Yuelin; Jiang, Hongmei; Li, Ruobi; Wang, Qing; Tang, Lu-Ying; Ren, Ze-Fang

doi:10.1016/j.jtemb.2020.126677

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…Other studies have shown that selenium can disrupt oestrogen signalling in cancer cells [ 250 ]. Furthermore, additional more recent in vitro studies have revealed that selenium can also act together with vitamin C to prevent tumour cell growth in both breast and colon carcinoma cell lines [ 241 , 251 , 252 ]. Nevertheless, more studies in this area are needed and assessment of the daily therapeutic level for the prevention of EC is required.…”

Section: Vitamins and Mineralsmentioning

confidence: 99%

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

Yasin

Taylor

Ayakannu

2021

Cancers

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Endometrial cancer is the most common cancer affecting the reproductive organs of women living in higher-income countries. Apart from hormonal influences and genetic predisposition, obesity and metabolic syndrome are increasingly recognised as major factors in endometrial cancer risk, due to changes in lifestyle and diet, whereby high glycaemic index and lipid deposition are prevalent. This is especially true in countries where micronutrients, such as vitamins and minerals are exchanged for high calorific diets and a sedentary lifestyle. In this review, we will survey the currently known lifestyle factors, dietary requirements and hormonal changes that increase an individual’s risk for endometrial cancer and discuss their relevance for clinical management. We also examine the evidence that everyday factors and clinical interventions have on reducing that risk, such that informed healthy choices can be made. In this narrative review, we thus summarise the dietary and lifestyle factors that promote and prevent the incidence of endometrial cancer.

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Section: Vitamins and Mineralsmentioning

confidence: 99%

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

Yasin

Taylor

Ayakannu

2021

Cancers

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“…With the development of high-throughput sequencing technologies, over 80% of genes are identified to be non-coding RNAs in the human genome, such as lncRNAs and miRNAs, which were initially thought to be transcriptional "noise" (24,25). Accumulated studies have reported that lncRNAs are critical in BC progression, and have focused on discovering novel diagnostic, therapeutic, and prognostic targets for BC from lncRNAs (26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of lncRNA SLC16A1-AS1 Suppresses the Growth and Metastasis of Breast Cancer via the miR-552-5p/WIF1 Signaling Pathway

2022

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BackgroundBreast cancer (BC) is the most common cancer and the fifth leading cause of cancer mortality with 685,000 deaths worldwide in 2020. Long non-coding RNAs (lncRNAs) are critical in BC carcinogenesis and progression. However, the functional roles and mechanisms of SLC16A1-AS1 in BC are unknown.MethodsThe expression profile of SLC16A1-AS1 in BC patients was investigated using data from The Cancer Genome Atlas (TCGA) database and checked in 80 BC patients, followed by analyzing the prognostic value of SLC16A1-AS1 in the 80 BC patients. The biological functions of SLC16A1-AS1 were further examined in vivo and in vitro after overexpression of SLC16A1-AS1 in BC cells. Possible binding sites between SLC16A1-AS1 and miR-552-5p were predicted by miRDB and those between miR-552-5p and Wnt inhibitory factor-1 (WIF1) were predicted by miRanda, which were confirmed using dual-luciferase reporter assay with mutation. Spearman correlation assay was applied to evaluate the association between genes. Rescue experiments were further applied to investigate the molecular mechanisms involved.ResultsLower SLC16A1-AS1 expression in BC tissues was related to poor prognosis of BC patients. Upregulation of SLC16A1-AS1 suppressed BC cell viability, colony formation, invasion, and migration in vitro and growth in vivo via sponging miR-552-5p to release WIF1.ConclusionSLC16A1-AS1 is a tumor suppressor in BC, and lower SLC16A1-AS1 expression is an indicator of poor prognosis in BC patients. SLC16A1-AS1 inhibits BC carcinogenesis and progression via the SLC16A1-AS1/miR-552-5p/WIF1 pathway. SLC16A1-AS1 represents a novel diagnostic, therapeutic, and prognostic target for BC management.

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“…Several studies found that NEDD4L was probably implicated in the anticancer or cancer-promoting effects of some substances in breast cancer. For instance, selenium (Se) is a lurking anticancer nutrient ( 79 ), and NEDD4L is considered as a key gene in the regulatory network of the Se-stimulated epigenome ( 80 ). Unexpectedly, Orai3 advanced calcium influx, activated NEDD4L and reduced the apoptosis of breast cancer cells by weakening the expression of p53 ( 81 ).…”

Section: The Function Of Nedd4l In Cancermentioning

confidence: 99%

Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers

et al. 2021

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Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that NEDD4L mainly functions as a tumor suppressor in most cancer types, while it also acts as an oncogene in a few cancers. In this review, we summarize the potential role of NEDD4L in carcinogenesis and the related underlying molecular mechanism to improve our understanding of its functions in the tumorigenesis of human malignancies. Developing clinical drugs targeting NEDD4L could be a potential therapeutic strategy for cancer therapy in the future.

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Differential epigenetic profiles induced by sodium selenite in breast cancer cells

Cited by 6 publications

References 43 publications

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

Overexpression of lncRNA SLC16A1-AS1 Suppresses the Growth and Metastasis of Breast Cancer via the miR-552-5p/WIF1 Signaling Pathway

Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers

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