Differential encoding of fear learning and fear expression in the ventral and dorsal hippocampus

Pompili, Marco N.; Hamou, Noé; Wiener, Sidney I.

doi:10.1101/2024.01.26.577384

Cited by 2 publications

(1 citation statement)

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“…Cell assemblies with synchronously active neurons from both the dorsal and ventral hippocampus neurons were shown to develop during the exposition to contextual fear conditioning (Pompili, Hamou, and Wiener 2024). Here, we detected dorsal, ventral, and dorso-ventral joint assemblies during aversive-motivated and rewarded-motivated exploration using the same set of neurons ( Figure 3A - B ).…”

Section: Discussionmentioning

confidence: 99%

Dorso-ventral hippocampal neural assemblies are preferentially reactivated during NREM sleep following an aversive experience

Morici,

Paiva-Lima,

Pronier

et al. 2024

Preprint

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Sleep plays a crucial role in memory stabilization. In the dorsal hippocampus (dHPC), fast oscillations (sharp-wave ripples) during non-REM sleep consolidate spatial memories through place cell reactivation. The hippocampal formation is heterogeneous; the dHPC processes mostly contextual information, while the ventral part (vHPC) encodes valence and anxiety. We propose that dorsal- ventral communication during sleep is involved in the consolidation of emotional memories, potentially integrating or segregating contextual and valence information. To test this, we recorded the electrophysiological activity in the dHPC and vHPC in rats during reward and aversion-motivated exploration of a linear track and subsequent sleep. We detected dorsal and ventral SWRs during NREM sleep as well as neuronal assemblies during each exploration type and identified dorsal, ventral, and joint (dorso-ventral) assemblies. We found that dorso-ventral hippocampal coordination involves coordinated ripples and bursts of ripples. Aversive joint assemblies exhibited higher reactivation during non-REM sleep than the joint assemblies from the reward condition. Interestingly, joint aversive assemblies reactivated selectively during dorso-ventral coordinated ripples. Furthermore, their reactivation strength positively correlated with their strength of activation during the task. These results suggest the existence of dorsal-ventral hippocampal functional communication capable of sustaining the selective reactivation of experiences based on their emotional valence.

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Section: Discussionmentioning

confidence: 99%

Dorso-ventral hippocampal neural assemblies are preferentially reactivated during NREM sleep following an aversive experience

Morici,

Paiva-Lima,

Pronier

et al. 2024

Preprint

View full text Add to dashboard Cite

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Flexible communication between cell assemblies and ‘reader’ neurons

Boucly

Pompili

Todorova

et al. 2022

Preprint

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Cell assemblies are considered fundamental units of brain activity, underlying diverse functions ranging from perception to memory and decision-making. Cell assemblies have historically been conceived of as internal representations of specific stimuli or actions. Alternatively, cell assemblies can be endogenously defined by their ability to effectively elicit specific responses in downstream ('reader') neurons. Yet, whether cell assemblies are selectively detected by downstream neurons remains unknown. Here, we provide evidence for such assembly-reader communication. Reader activation was genuinely collective, functionally selective, yet flexible, implementing both pattern separation and completion. These processes occurred at the time scale of membrane integration, synaptic plasticity and gamma oscillations. Finally, assembly-reader couplings were selectively modified upon learning, indicating that they were plastic and reflected behaviorally relevant variables. These results support cell assemblies as an endogenous mechanism for brain function.

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Differential encoding of fear learning and fear expression in the ventral and dorsal hippocampus

Cited by 2 publications

References 61 publications

Dorso-ventral hippocampal neural assemblies are preferentially reactivated during NREM sleep following an aversive experience

Dorso-ventral hippocampal neural assemblies are preferentially reactivated during NREM sleep following an aversive experience

Flexible communication between cell assemblies and ‘reader’ neurons

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