Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health
Changli Zhang,
Madeleine D. Gordon,
Katherine M. Joseph
et al.
Abstract:BackgroundIntervertebral disc (IVD) degeneration is associated with chronic back pain. We previously demonstrated that the phosphatase pleckstrin homology domain and leucine‐rich repeat protein phosphatase (PHLPP) 1 was positively correlated with IVD degeneration and its deficiency decelerated IVD degeneration in both mouse IVDs and human nucleus pulposus (NP) cells. Small molecule PHLPP inhibitors may offer a translatable method to alleviate IVD degeneration. In this study, we tested the effectiveness of the … Show more
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