Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana

Fried, Peter A.; Watkinson, Barbara; Gray, Robert M.

doi:10.1016/s0892-0362(03)00029-1

Cited by 343 publications

(196 citation statements)

References 28 publications

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“…Prospective clinical studies have provided evidence that prenatal exposure to maternal smoking is associated with deficits in auditory processing among offspring that persist through adolescence (Fried et al, 1997(Fried et al, , 2003McCartney et al, 1994). Recent preclinical work indicates that nicotine exposure during early postnatal development, corresponding to the third trimester of pregnancy in humans, resulted in impaired function of nAChRs in primary auditory cortex localized on neurons that regulate thalamocortical inputs (Liang et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Controlled, prospective clinical studies have linked maternal smoking during pregnancy with persistent deficits in general intellectual function and auditory processing in offspring (Fried et al, 1997(Fried et al, , 2003McCartney et al, 1994). Converging evidence from preclinical work has identified nicotine as the chief teratogenic component of tobacco smoke contributing to adverse neurodevelopmental sequelae associated with prenatal exposure to maternal smoking (Slotkin, 2004;Slotkin et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Gender-Specific Effects of Prenatal and Adolescent Exposure to Tobacco Smoke on Auditory and Visual Attention

Jacobsen

Slotkin

Mencl

et al. 2007

Neuropsychopharmacol

136

143

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Prenatal exposure to active maternal tobacco smoking elevates risk of cognitive and auditory processing deficits, and of smoking in offspring. Recent preclinical work has demonstrated a sex-specific pattern of reduction in cortical cholinergic markers following prenatal, adolescent, or combined prenatal and adolescent exposure to nicotine, the primary psychoactive component of tobacco smoke. Given the importance of cortical cholinergic neurotransmission to attentional function, we examined auditory and visual selective and divided attention in 181 male and female adolescent smokers and nonsmokers with and without prenatal exposure to maternal smoking. Groups did not differ in age, educational attainment, symptoms of inattention, or years of parent education. A subset of 63 subjects also underwent functional magnetic resonance imaging while performing an auditory and visual selective and divided attention task. Among females, exposure to tobacco smoke during prenatal or adolescent development was associated with reductions in auditory and visual attention performance accuracy that were greatest in female smokers with prenatal exposure (combined exposure). Among males, combined exposure was associated with marked deficits in auditory attention, suggesting greater vulnerability of neurocircuitry supporting auditory attention to insult stemming from developmental exposure to tobacco smoke in males. Activation of brain regions that support auditory attention was greater in adolescents with prenatal or adolescent exposure to tobacco smoke relative to adolescents with neither prenatal nor adolescent exposure to tobacco smoke. These findings extend earlier preclinical work and suggest that, in humans, prenatal and adolescent exposure to nicotine exerts gender-specific deleterious effects on auditory and visual attention, with concomitant alterations in the efficiency of neurocircuitry supporting auditory attention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gender-Specific Effects of Prenatal and Adolescent Exposure to Tobacco Smoke on Auditory and Visual Attention

Jacobsen

Slotkin

Mencl

et al. 2007

Neuropsychopharmacol

136

143

View full text Add to dashboard Cite

show abstract

“…We propose that inconsistencies between studies could be the consequence of differences in sociodemographic variation between the samples or of cohort effects. For example, we note that the Ottawa Pregnancy Prospective Study investigated a low-risk, predominantly middle class sample (Fried et al, 2003) and the sample tested by Olds et al (1994) consisted of families of predominantly poor, teenage, or unmarried mothers. Both could be considered relatively sociodemographically homogeneous.…”

Section: Discussionmentioning

confidence: 99%

“…Both prenatal smoking (Batstra, Hadders-Algra, & Neeleman, 2003;Cornelius, Ryan, Day, Goldschmidt, & Willford, 2001;Fried et al, 2003;Kristjansson, Fried, & Watkinson, 1989;Mortensen, Michaelsen, Sanders, & Reinisch, 2005;Olds, Henderson, & Tatelbaum, 1994;Sexton, Fox, & Hebel, 1990) and birth weight (across the entire spectrum of birth weight, ranging up to 4-4.5 kg) (Breslau et al, 1996;Jefferis, Power, & Hertzman, 2002;Shenkin, Starr, & Deary, 2004) may be independent predictors of children's cognitive abilities, although reports have not been consistent. An increasing number of studies show that associations between prenatal smoking and offspring cognitive abilities are accounted for by specific sociodemographic factors such as parental IQ, parental education, SES, and family environment (Baghurst, Tong, Wood-ward, & McMichael, 1992;Breslau, Paneth, Lucia, & Paneth-Pollak, 2005;Fergusson & Lloyd, 1991;Lawlor et al, 2006;MacArthur, Knox, & Lancashire, 2001;McGee & Stanton, 1994;Trasti, Vik, Jakobsen, & Bakketeig, 1999).…”

Section: Introductionmentioning

confidence: 99%

Interrelations between maternal smoking during pregnancy, birth weight and sociodemographic factors in the prediction of early cognitive abilities

Huijbregts

Séguin

Zelazo

et al. 2006

Infant and Child Development

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Maternal prenatal smoking, birth weight and sociodemographic factors were investigated in relation to cognitive abilities of 1544 children (aged 3.5 years) participating in the Québec Longitudinal Study of Children's Development. The Peabody Picture Vocabulary Test (PPVT) was used to assess verbal ability, the Wechsler Preschool and Primary Scale of Intelligence-Revised (WPPSI-R) block design test to assess visuospatial ability, and the Visually Cued Recall (VCR) task to assess short-term memory. Prenatal smoking was related to performance on the WPPSI-R, the PPVT, and the VCR, although it did not independently predict any cognitive ability after maternal education was taken into account. Birth weight was a more robust predictor of all outcome measures and independently predicted VCR-performance. Birth weight interacted significantly with family income and maternal education in predicting visuospatial ability, indicating a greater influence of birth weight under relatively poor socio-economic conditions. Parenting and family functioning mediated associations between maternal education/family income and cognitive task performance under different birth weight conditions, although there were indications for stronger effects under relatively low birth weight. We conclude that investigations of moderating and mediating effects can provide insights into which children are most at risk of cognitive impairment and might benefit most from interventions.

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“…Prospective clinical studies have linked prenatal exposure to tobacco smoke to reductions in motor and verbal comprehension scores in children assessed at 13 months of age (Gusella and Fried, 1984), reductions in measures of language development, and general intellectual function in children assessed at 3, 4, 5, and 6 years of age (Fried and Watkinson, 1990;Fried et al, 1992), deficits in verbal and nonverbal learning and memory in preadolescents (Cornelius et al, 2001), and reductions in general intelligence in children assessed between 9 and 16 years of age (Fried et al, 1998(Fried et al, , 2003.…”

Section: Introductionmentioning

confidence: 99%

Visuospatial Memory Deficits Emerging During Nicotine Withdrawal in Adolescents with Prenatal Exposure to Active Maternal Smoking

Jacobsen

Slotkin

Westerveld

et al. 2005

Neuropsychopharmacol

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Active maternal smoking during pregnancy elevates the risk of cognitive deficits and tobacco smoking among offspring. Preclinical work has shown that combined prenatal and adolescent exposure to nicotine produces more pronounced hippocampal changes and greater deficits in cholinergic activity upon nicotine withdrawal than does prenatal or adolescent exposure to nicotine alone. Few prior studies have examined the potential modifying effects of gestational exposure to active maternal smoking on cognitive or brain functional response to tobacco smoking or nicotine withdrawal in adolescents. We examined visuospatial and verbal memory in 35 adolescent tobacco smokers with prenatal exposure to active maternal smoking and 26 adolescent tobacco smokers with no prenatal exposure to maternal smoking who were similar in age, educational attainment, general intelligence, and baseline plasma cotinine. Subjects were studied during ad libitum smoking and after 24 h of abstinence from smoking. A subset of subjects from each group also underwent functional magnetic resonance imaging while performing a visuospatial encoding and recognition task. Adolescent tobacco smokers with prenatal exposure experienced greater nicotine withdrawal-related deficits in immediate and delayed visuospatial memory relative to adolescent smokers with no prenatal exposure. Among adolescent smokers with prenatal exposure, nicotine withdrawal was associated with increased activation of left parahippocampal gyrus during early recognition testing of visuospatial stimuli and increased activation of bilateral hippocampus during delayed recognition testing of visuospatial stimuli. These findings extend prior preclinical work and suggest that, in human adolescent tobacco smokers, prenatal exposure to active maternal smoking is associated with alterations in medial temporal lobe function and concomitant deficits in visuospatial memory.

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Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana

Cited by 343 publications

References 28 publications

Gender-Specific Effects of Prenatal and Adolescent Exposure to Tobacco Smoke on Auditory and Visual Attention

Gender-Specific Effects of Prenatal and Adolescent Exposure to Tobacco Smoke on Auditory and Visual Attention

Interrelations between maternal smoking during pregnancy, birth weight and sociodemographic factors in the prediction of early cognitive abilities

Visuospatial Memory Deficits Emerging During Nicotine Withdrawal in Adolescents with Prenatal Exposure to Active Maternal Smoking

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