Differential effects of voluntary wheel running and toy rotation on the mRNA expression of neurotrophic factors and FKBP5 in a post-traumatic stress disorder rat model with the shuttle-box task

Tanichi, Masaaki; Toda, Hiroyuki; Shimizu, Kunio; Koga, Minoru; Saito, Taku; Enomoto, Shingo; Boku, Shuken; Asai, Fumiho; Mitsui, Yumi; Nagamine, Masato; Fujita, Masanori; Yoshino, Aihide

doi:10.1016/j.bbrc.2018.05.023

Cited by 15 publications

(16 citation statements)

References 29 publications

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“…GDNF is reported to be delivered to neuronal soma via retrograde transport , therefore, cells containing GDNF may be representative of either GDNF‐receiving or GDNF‐producing cells. Given that GDNF mRNA is present in the human hippocampus and specifically in hippocampal neurons in both rodents and humans , it is likely that the neurons found to be immunopositive for GDNF in this study may be producing rather than receiving GDNF. If so, reduced levels of GDNF may not only affect the hippocampus itself, but also other brain regions which innervate it and which may be dependent on receiving GDNF from hippocampal neurons.…”

Section: Discussionmentioning

confidence: 94%

Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease

et al. 2019

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Growth factors can facilitate hippocampus‐based learning and memory and are potential targets for treatment of cognitive dysfunction via their neuroprotective and neurorestorative effects. Dementia is common in Parkinson’s disease (PD), but treatment options are limited. We aimed to determine if levels of growth factors are altered in the hippocampus of patients with PD, and if such alterations are associated with PD pathology. Enzyme‐linked immunosorbent assays were used to quantify seven growth factors in fresh frozen hippocampus from 10 PD and nine age‐matched control brains. Western blotting and immunohistochemistry were used to explore cellular and inflammatory changes that may be associated with growth factor alterations. In the PD hippocampus, protein levels of glial cell line‐derived neurotrophic factor were significantly decreased, despite no evidence of neuronal loss. In contrast, protein levels of fibroblast growth factor 2 and cerebral dopamine neurotrophic factor were significantly increased in PD compared to controls. Levels of the growth factors epidermal growth factor, heparin‐binding epidermal growth factor, brain‐derived neurotrophic factor and mesencephalic astrocyte‐derived neurotrophic factor did not differ between groups. Our data demonstrate changes in specific growth factors in the hippocampus of the PD brain, which potentially represent targets for modification to help attenuate cognitive decline in PD. These data also suggest that multiple growth factors and direction of change needs to be considered when approaching growth factors as a potential treatment for cognitive decline.

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Section: Discussionmentioning

confidence: 94%

Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease

et al. 2019

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“…EE has been associated with enhanced neurogenesis and increased expression of brain derived neurotrophic factor (BDNF), and those are often suggested to mediate the beneficial effects of EE on learning and memory and on stress resilience 22,23 . Exposure to stress and trauma 24 , including exposure to pre-pubertal stress 25 , is suggested to result in reduced expression of BDNF and impaired neurogenesis in the hippocampus, and EE is assumed to reverse these effects by enhancing hippocampal neurogenesis and BDNF expression 22,26–32 . In addition, EE was found to prevent the reduction in hippocampal volume in an animal model of PTSD 33 .…”

Section: Discussionmentioning

confidence: 99%

The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience

Ardi

Richter-Levin

et al. 2019

Sci Rep

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Pre-pubertal stress increases post-traumatic stress disorder (PTSD) susceptibility. We have previously demonstrated that enriched environment (EE) intervention immediately after pre-pubertal stress protects from the effects of trauma in adulthood. Here, we examined whether exposure to EE would also be beneficial if applied after exposure to trauma in adulthood. We have recently shown that exposure to juvenile stress and under-water trauma (UWT) is associated with increased expression of GABAA receptor subunit α1 in the ventral hippocampus. However, differentiating between affected and unaffected individuals, this increased expression was confined to stress-exposed, behaviorally unaffected individuals, suggesting upregulation of α1 expression as a potential mechanism of resilience. We now examined whether EE-induced resilience renders increased expression of α1 in the ventral hippocampus redundant when facing a trauma later in life. Adult rats were exposed to UWT, with pre-exposure to juvenile stress, and tested in the open field and elevated plus maze paradigms four weeks later. EE exposure during juvenility prevented pre-pubertal stress-induced vulnerability, but not if performed following UWT in adulthood. Furthermore, juvenile EE exposure prevented the trauma-associated increase in α1 expression levels. Our findings emphasize the importance of early interventions in order to reduce the likelihood of developing psychopathologies in adulthood.

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“…Besides, testosterone and nandrolone affect the nerve growth factor (NGF) in brain by different mechanisms. NGF is known by regulating memory, learning, and defensive behavior (Tanichi et al, 2018). Thus, an unbalance in the concentration of NGF could lead to an impairment in neurobehavioral status.…”

Section: Discussionmentioning

confidence: 99%

Anabolic-androgenic steroids cycle administration decreases anxious-like behavior but does not affect long-term memory acquisition in rats

Oliveira

Staudt

Machado

2019

Acta Sci. Biol. Sci.

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The steroid hormones are lipids in nature, which play crucial roles in several metabolic and behavioral pathways in mammals. Drug therapy uses sterol hormones for treating some disturbances linked with its deficiency; however, the illicit use of these hormones by amateur and elite athletes to enhance performance or body appearance may lead to several health issues. In this study we evaluated the anxious-like behavior and the long-term memory acquisition of male rats undergoing sedentary lifestyle or physical effort, with or without anabolic-androgenic steroids (ASC) treatment. The results showed a decrease in anxious-like behavioral levels in rats that received ASC treatment associated or not with physical effort, but this treatment did not affect the acquisition of long-term memory at the dose and experimental model assessed.

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Differential effects of voluntary wheel running and toy rotation on the mRNA expression of neurotrophic factors and FKBP5 in a post-traumatic stress disorder rat model with the shuttle-box task

Cited by 15 publications

References 29 publications

Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease

Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease

The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience

Anabolic-androgenic steroids cycle administration decreases anxious-like behavior but does not affect long-term memory acquisition in rats

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