Differential Effects of Various Electrical Parameters on Peripheral and Central Nerve Regeneration

Zanakis, Michael F.

doi:10.3727/036012990816358199

Cited by 13 publications

(7 citation statements)

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“…Application of electric fields was used by several investigators to promote nerve regeneration (Broniatowski et al, 1987;Broniatowski et al, 1989;Zanakis, 1990;Pomeranz and Campbell, 1993). The results of our experiments now demonstrate for the first time a direct influence of applied current to the original nucleus of a peripheral nerve, that is reminescent of the axon reaction.…”

Section: Discussionmentioning

confidence: 83%

Dual Mode of Signalling of the Axotomy Reaction: Retrograde Electric Stimulation or Block of Retrograde Transport Differently Mimic the Reaction of Motoneurons to Nerve Transection in the Rat Brainstem

Mader

Andermahr²,

Angelov³

et al. 2004

Journal of Neurotrauma

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Axotomy of a peripheral nerve causes a complex central response of neuronal perikarya, astroglia and microglia. The signal initiating this axotomy reaction is currently explained either by deprivation of target-derived trophic factors after interruption of transport (trophic hypothesis) or by electrophysiological disturbances of the axotomized neurons (electric hypothesis). In 108 adult Wistar rats we have compared the time course and intensity of the axotomy reaction in the hypoglossal nucleus after (1) resection of the nerve (permanent axotomy), (2) one-time electric stimulation (intact nerve, brief transient electric disturbance), and (3) colchicine block of transport (intact nerve, prolonged transient loss of trophic factors). Nerve resection activated microglia at 2-35 days post-operation (dpo), elevated GFAP in astrocytes at 3-35 dpo and increased CGRP in motoneurons at 2-15 dpo. Fluorogold prelabeling revealed neurophagocytosis and 25% neuron loss at 25 dpo. Colchicine block similarly activated microglia at 5-35 dpo, elevated GFAP at 7-35 dpo and upregulated CGRP at 7-25 dpo. Neurophagocytosis and 15% motoneuron loss were evident at 25 dpo. Electric stimulation (15 min, 4 Hz, 0.1 msec impulse, 2 mAmp) of the intact nerve activated microglia at 1-10 dpo, elevated astroglial GFAP-expression at 7-35 dpo, and upregulated CGRP at 1-10 dpo, but no neuron death and neurophagocytosis were detected. Hence electric stimulation elicited a faster, shorter-lasting response, but transport block as well as axotomy a slower, longer-lasting response. This suggests a dual mode of signaling: Onset and early phase of the axotomy reaction are triggered by electric disturbances, late phase and neuron death by deprivation of trophic factors.

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Section: Discussionmentioning

confidence: 83%

Dual Mode of Signalling of the Axotomy Reaction: Retrograde Electric Stimulation or Block of Retrograde Transport Differently Mimic the Reaction of Motoneurons to Nerve Transection in the Rat Brainstem

Mader

Andermahr²,

Angelov³

et al. 2004

Journal of Neurotrauma

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“…Secondly, electric stimulation can promote capillary regeneration and increase blood perfusion and exudation of some components in blood, exerting nourishing effects on nerves and muscles [4] . Thirdly, electric stimulation can affect electric current balance of calcium ions in growth cone to direct nerve growth cone.…”

Section: Discussionmentioning

confidence: 99%

Clinical observation of electroacupuncture and acupoint injection in treating common fibular nerve paralysis

Cheng

Jiang

Si-si

et al. 2008

J. Acupunct. Tuina. Sci.

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CHENG Xiao-fang ( ), JIANG Jin-ping ( ), PANG Si-si ( ), LUO Hua ( ), PENG Yan-ling ( ) : nerve growth factor NGF DPN : 40 B :P<0.05 P<0.01 P<0.01 :Abstract Objective: To observe the clinical efficacy of combined electroacupuncture and nerve growth factor(NGF) injection at acupoints in the treatment of common fibular nerve paralysis and provide evidences for integrative Chinese & western medicine against diabetic peripheral neuropathy(DPN). Methods: Forty subjects were randomized into two groups and treated by routine therapy. Moreover, treatment group was given electro-acupuncture and NGF injection; and control group was given herbal suffocation, oral Dibazol and compound vitamin B and Mecobalamin Injection. The clinical symptoms and nerve conduction velocity were observed and compared. Results: The cure rate was higher in treatment group than in control group (P<0.05); after treatment, the nerve conduction velocity was improved in both groups (P<0.01), with a significant improvement in treatment group than in control group (P<0.01). Conclusion: Combined electro-acupuncture and NGF injection at acupoints is quite effective in the treatment of common fibular nerve paralysis.

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“…Recently, numerous research studies have been examining the effects of electrical conductivity and electrical stimulation of the cells. PLLA fibers have also been known to regulate cell attachment, proliferation, and differentiation of nerve cell axonal extension [34], healing of bones [35], cartilage [36], skin, connective tissues [37], cranial, spinal [38,39] and peripheral nerves [40,41]. In a study by Schmidt et al, the effect of electrical stimulus through a scaffold film was recorded in muscle and neuronal cells [42].…”

Section: Characterizationmentioning

confidence: 99%

Enhancing the Cell Growth Using Conductive Scaffolds

Habis¹,

Lafdi²,

Pa³

et al. 2018

J Nanomed Nanotechnol

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Differential Effects of Various Electrical Parameters on Peripheral and Central Nerve Regeneration

Cited by 13 publications

References 0 publications

Dual Mode of Signalling of the Axotomy Reaction: Retrograde Electric Stimulation or Block of Retrograde Transport Differently Mimic the Reaction of Motoneurons to Nerve Transection in the Rat Brainstem

Dual Mode of Signalling of the Axotomy Reaction: Retrograde Electric Stimulation or Block of Retrograde Transport Differently Mimic the Reaction of Motoneurons to Nerve Transection in the Rat Brainstem

Clinical observation of electroacupuncture and acupoint injection in treating common fibular nerve paralysis

Enhancing the Cell Growth Using Conductive Scaffolds

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