Differential Effects of Transcranial Static Magnetic Stimulation Over Left and Right Dorsolateral Prefrontal Cortex on Brain Oscillatory Responses During a Working Memory Task

Watanabe, Tatsunori; Chen, Xiaoxiao; Yunoki, Keisuke; Matsumoto, Takuya; Horinouchi, Takayuki; Ito, K.; Ishida, Haruki; Sunagawa, Toru; Mima, Tatsuya; Kirimoto, Hikari

doi:10.1016/j.neuroscience.2023.03.006

Cited by 3 publications

(4 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result was in line with that of a previous meta‐analysis study 65 . Studies comparing left and right DLPFC stimulation have also shown that the stimulation over left DLPFC performs better than the right DLPFC in terms of working memory and executive function 66,67 …”

Section: Discussionsupporting

confidence: 89%

Efficacy of scalp stimulation for multidomain cognitive impairment in patients with post‐stroke cognitive impairment and dementia: A network meta‐analysis and meta‐regression of moderators

Xu,

Li,

Zhang

et al. 2023

J Evidence Based Medicine

View full text Add to dashboard Cite

BackgroundScalp stimulation has gained more traction for post‐stroke cognitive impairment and dementia (PSCID); the interaction between stimulation targets and parameters influences the response to the stimulation. However, the most efficacious treatment for improving different domains of cognitive impairment remains unknown.ObjectiveWe aimed to conduct a systematic review and network meta‐analysis (NMA) to compare the efficacy of various scalp stimulation protocols used in PSCID treatment.MethodsRandomized controlled trials of scalp stimulation in patients with PSCID were searched in eight databases over the past 20 years. Standardized mean differences (SMDs) for global and subdomain cognitive scores were pooled in Bayesian NMA. Moderators were examined using meta‐regression analysis.ResultsA total of 90 trials, with 6199 patients, were included. Low‐frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected dorsolateral prefrontal cortex (DLPFC) was highly suggested for alleviating global severity (SMD = 1.11, 95% CI (0.64, 1.57)). High‐frequency rTMS over the left DLPFC was recommended for language use (1.85 (1.18, 2.52)), executive function (0.85 (0.36, 1.33)), orientation deficits (0.59 (0.07, 1.13)), and attention (0.85 (0.27, 1.43)). Anodal transcranial direct current stimulation over the affected DLPFC (2.03 (0.72, 3.34)) was recommended for treating memory impairment. Meta‐regression analyses showed significant associations within attention, language and orientation.ConclusionOverall, different cognitive domains have different optimal scalp stimulation prescriptions, and activating the affected key brain regions and inhibiting the unaffected area is still the most effective treatment.

show abstract

Section: Discussionsupporting

confidence: 89%

Efficacy of scalp stimulation for multidomain cognitive impairment in patients with post‐stroke cognitive impairment and dementia: A network meta‐analysis and meta‐regression of moderators

Xu,

Li,

Zhang

et al. 2023

J Evidence Based Medicine

View full text Add to dashboard Cite

show abstract

“…First, we did not assess activity of the MAC or connectivity between the brain regions. Since brain activity/connectivity can be modulated by tSMS ( Gonzalez-Rosa et al, 2015 ; Chen et al, 2021 ; Shibata et al, 2021 ; Watanabe et al, 2023 ), future studies should consider this aspect. Second, accuracy of SRT and CRT tasks declined as experiment progressed.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison to the other NIBS expected to induce inhibitory effects, such as cathodal transcranial direct current stimulation (tDCS) ( Nitsche and Paulus, 2000 ), low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) ( Chen et al, 1997 ), continuous theta-burst stimulation (cTBS) ( Huang et al, 2005 ), which induce electric current flow, tSMS (that induces SMF) causes less discomfort to the participants and is safe, economical, and easy to handle. In the past decade, various local brain regions such as the sensorimotor ( Silbert et al, 2013 ; Kirimoto et al, 2014 , 2016 , 2018 ; Nojima et al, 2015 , 2019 ; Davila-Perez et al, 2019 ; Nakagawa et al, 2019 ; Shibata et al, 2020 ), supplementary motor ( Kirimoto et al, 2016 ; Pineda-Pardo et al, 2019 ; Tsuru et al, 2020 ; Guida et al, 2023 ), visual ( Gonzalez-Rosa et al, 2015 ; Oliviero et al, 2015 ; Lozano-Soto et al, 2018 ), and dorsolateral prefrontal ( Sheffield et al, 2019 ; Chen et al, 2021 ; Watanabe et al, 2021 , 2023 ; Soto-León et al, 2023 ) cortices have been revealed to be modulated by tSMS, with potential clinical applications for neurological disorders ( Di Lazzaro et al, 2021 ; Dileone et al, 2022 ; Shimomura et al, 2023 ). In addition, a new tSMS device constructed with three NdFeB magnets (called “SHIN jiba”) was introduced last year, and simulation has revealed that this triple tSMS can produce the greater static magnetic fields than the conventional tSMS ( Shibata et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, the purpose of the present study was to investigate the effect of tSMS over the unilateral or bilateral MAC on performance of RT tasks. Since the effect of tSMS has been revealed to depend on task difficulty ( Gonzalez-Rosa et al, 2015 ; Chen et al, 2021 ; Watanabe et al, 2021 , 2023 ), we adopted simple and choice reaction time (SRT and CRT) tasks, as the CRT task, requiring additional visual attention and cognitive resources to select the effector, is considered more difficult than the SRT task. We hypothesized that tSMS over the MAC would influence the RT performance particularly when the triple tSMS was applied over the bilateral MAC during the CRT task.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of transcranial static magnetic stimulation over unilateral or bilateral motor association cortex on performance of simple and choice reaction time tasks

Matsumoto,

Watanabe,

Ito

et al. 2023

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

BackgroundTranscranial static magnetic stimulation (tSMS) is a non-invasive brain stimulation technique that place a strong neodymium magnet on scalp to reduce cortical excitability. We have recently developed a new tSMS device with three magnets placed close to each other (triple tSMS) and confirmed that this new device can produce a stronger and broader static magnetic field than the conventional single tSMS. The aim of the present study was to investigate the effect of the conventional single tSMS as well as triple tSMS over the unilateral or bilateral motor association cortex (MAC) on simple and choice reaction time (SRT and CRT) task performance.MethodsThere were two experiments: one involved the conventional tSMS, and the other involved the triple tSMS. In both experiments, right-handed healthy participants received each of the following stimulations for 20 min on different days: tSMS over the unilateral (left) MAC, tSMS over the bilateral MAC, and sham stimulation. The center of the stimulation device was set at the premotor cortex. The participants performed SRT and CRT tasks before, immediately after, and 15 min after the stimulation (Pre, Post 0, and Post 15). We evaluated RT, standard deviation (SD) of RT, and accuracy (error rate). Simulation was also performed to determine the spatial distribution of magnetic field induced by tSMS over the bilateral MAC.ResultsThe spatial distribution of induced magnetic field was centered around the PMd for both tSMS systems, and the magnetic field reached multiple regions of the MAC as well as the sensorimotor cortices for triple tSMS. SD of CRT was significantly larger at Post 0 as compared to Pre when triple tSMS was applied to the bilateral MAC. No significant findings were noted for the other conditions or variables.DiscussionWe found that single tSMS over the unilateral or bilateral MAC did not affect performance of RT tasks, whereas triple tSMS over the bilateral MAC but not over the unilateral MAC increased variability of CRT. Our finding suggests that RT task performance can be modulated using triple tSMS.

show abstract

High-Frequency rTMS Broadly Ameliorates Working Memory and Cognitive Symptoms in Stroke Patients: A Randomized Controlled Trial

Liu,

Ai,

Cao

et al. 2024

Neurorehabil Neural Repair

View full text Add to dashboard Cite

Objective To explore the efficacy and tolerability of high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of post-stroke working memory (WM) impairment and its changes in brain function. Methods In the present randomized, double-blinded, sham-controlled design, 10 Hz rTMS was administered to the left dorsolateral prefrontal cortex (DLPFC) of patients with post-stroke WM impairment for 14 days. Measures included WM (primary outcome), comprehensive neuropsychological tests, and the functional near-infrared spectroscopy test. Patients were assessed at baseline, after the intervention (week 2), and 4 weeks after treatment cessation (week 6). Results Of 123 stroke patients, 82 finished the trial. The rTMS group showed more WM improvement at week 2 ( t = 5.55, P < .001) and week 6 ( t = 2.11, P = .045) than the sham group. Most of the neuropsychological test scores were markedly improved in the rTMS group. In particular, the rTMS group exhibited significantly higher oxygenated hemoglobin content and significantly stronger functional connectivity in the left DLPFC, right pre-motor cortex (PMC), and right superior parietal lobule (SPL) at weeks 2 and 6. Dropout rates were equal (18% [9/50 cases] in each group), and headaches were the most common side effect (rTMS: 36% [18/50 cases]; sham: 30% [15/50 cases]). Conclusions High-frequency rTMS was effective in improving post-stroke WM impairment, with good tolerability, and the efficacy lasted up to 4 weeks, which may be due to the activation of the left DLPFC, right PMC, and right SPL brain regions and their synergistic enhancement of neural remodeling.

show abstract

Differential Effects of Transcranial Static Magnetic Stimulation Over Left and Right Dorsolateral Prefrontal Cortex on Brain Oscillatory Responses During a Working Memory Task

Cited by 3 publications

References 81 publications

Efficacy of scalp stimulation for multidomain cognitive impairment in patients with post‐stroke cognitive impairment and dementia: A network meta‐analysis and meta‐regression of moderators

Efficacy of scalp stimulation for multidomain cognitive impairment in patients with post‐stroke cognitive impairment and dementia: A network meta‐analysis and meta‐regression of moderators

Effect of transcranial static magnetic stimulation over unilateral or bilateral motor association cortex on performance of simple and choice reaction time tasks

High-Frequency rTMS Broadly Ameliorates Working Memory and Cognitive Symptoms in Stroke Patients: A Randomized Controlled Trial

Contact Info

Product

Resources

About