Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats

Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats

“…These temporal patterns reflect well-documented reductions in active behaviour as the test session progresses (e.g. Ishii et al 2003Ishii et al , 2004Ishii et al , 2005. However, it is noteworthy that the large increase in resting behaviour typically observed during the second half of the test session was not as marked as in previous experiments.…”

“…As any one or a combination of these effects could interfere with feeding behaviour, the principal aim of the present study was to comprehensively profile the acute behavioural effects of rimonabant in non-deprived male rats during a 1-h test with palatable food (e.g. Halford et al 1998;Rodgers et al 2001;Ishii et al 2003Ishii et al , 2004Ishii et al , 2005.…”

Orexin Signaling in the Ventral Tegmental Area Is Required for High-Fat Appetite Induced by Opioid Stimulation of the Nucleus Accumbens

“…Using intraperitoneal administration, it was shown that the profile of food intake suppression is very different for SB334867 and malaise producing lithium chloride, with the antagonist preserving the structure of feeding behavior but selectively enhancing the behavioral satiety sequence (Rodgers et al, 2000;Rodgers et al, 2001;Ishii et al, 2004Ishii et al, , 2005. The fact that even the highest dose of ventricular administration did not completely suppress DAMGO-induced feeding suggests that the blocker did not diffuse at high enough concentration to the VTA.…”

International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin Receptor Function, Nomenclature and Pharmacology

“…The effect of OX-A on food intake, however, is diminished or absent in aged rats, and Western blots suggest that decreased OX 1 receptor levels may be responsible for the diminished feeding response (Takano et al, 2004;Kotz et al, 2005). It is noteworthy that acute treatment with SB-334867 or an anti-orexin antibody reduced levels of natural feeding, often leading to a reduction in body weight (Haynes et al, 2000(Haynes et al, , 2002Yamada et al, 2000;Rodgers et al, 2001;Ishii et al, 2004Ishii et al, , 2005. SB-334867 has further been observed to have anorectic action and to accelerate satiety (Haynes et al, 2000;Rodgers et al, 2001;Ishii et al, 2005).…”