Differential effects of tenidap on the zymosan- and lipopolysaccharide-induced expression of mrna for proinflammatory cytokines in macrophages

Bondeson, Jan; Sundler, Roger

doi:10.1016/0006-2952(96)00136-0

Cited by 16 publications

(4 citation statements)

References 24 publications

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“…Classical non-steroidal anti-inflammatory drugs do not inhibit cytokine production, and even the inhibition of PG synthesis can potentiate the LPS-induced expression of TNFα mRNA and the levels of this cytokine (Bondeson and Sundler 1996). Glucocorticoids, such as dexamethasone, reduce cytokine levels, inhibit the expression of iNOS and reduce PG synthesis due to inhibition of COX-2 induction (Mitchell et al 1994) or to reduction in substrate availability .…”

Section: Discussionmentioning

confidence: 99%

Suppression of leukotriene B4 and tumour necrosis factor α release in acute inflammatory responses by novel prenylated hydroquinone derivatives

Terencio

Ferrándiz

Posadas

et al. 1998

Naunyn-Schmiedeberg's Arch Pharmacol

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A series of prenyl hydroquinone derivatives synthesized as structural analogs of marine products were tested for their effects on inflammatory responses in vitro and in vivo. 2-Prenyl-1,4-hydroquinone (H1), 2-diprenyl-1,4-hydroquinone (H2), 2-triprenyl-1,4-hydroquinone (H3) and 2-tetraprenyl-1,4-hydroquinone (H4) scavenged reactive oxygen species and inhibited 5-lipoxygenase (5-LO) activity in human neutrophils. The inhibition of 5-LO activity was demonstrated in vivo in the mouse air pouch injected with zymosan and arachidonic acid-induced ear inflammation. The four compounds suppressed the production of tumour necrosis factor alpha (TNFalpha) in J774 cells stimulated with lipopolysaccharide (LPS) and also in vivo in the mouse air pouch injected with zymosan. In addition, all prenyl-hydroquinones inhibited the release of nitrite and PGE2 in LPS-stimulated J774 cells, without direct effects on cyclo-oxygenase-1 (COX-1), cyclo-oxygenase-2 (COX-2) or inducible nitric oxide synthase (iNOS) activities in several cell-free systems. The reduction in the length of the lateral chain in prenyl-hydroquinones (1-4 isoprene units) with respect to their marine analogs (7-8 isoprene units) has improved the anti-inflammatory activity of this class of compounds. Marine natural products may be a model to design new anti-inflammatory agents.

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Section: Discussionmentioning

confidence: 99%

Suppression of leukotriene B4 and tumour necrosis factor α release in acute inflammatory responses by novel prenylated hydroquinone derivatives

Terencio

Ferrándiz

Posadas

et al. 1998

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Phagocytosis of zymosan by macrophages is mediated through different receptors such as the mannose receptor, complement receptor 3, Toll-like receptor 2, as well as dectin-1 [125 -129]. The zymosan-induced inflammatory products include cytokines [e. g., tumor necrosis factor (TNF)-a, interleukin (IL)-1b, IL-6, and IL-8], hydrogen peroxide, and arachidonic acid [122,124,130]. A broad range of cell types, including macrophages, PMNs, and natural killer cells, can be activated by zymosan [reviewed in refs 120, 131].…”

Section: Zymosan-induced Multiple Organ Failure (Mof)mentioning

confidence: 99%

The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-κB in inflammatory disorders

Hassa¹,

Hottiger²

2002

CMLS, Cell. Mol. Life Sci.

399

334

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Mammalian poly(ADP-ribose)polymerase 1 (PARP-1) is an abundant nuclear chromatin-associated protein and belongs to a large family of enzymes that catalyzes the transfer of ADP-ribose units from its substrate beta-nicotinamide adenine dinucleotide (NAD+) covalently to itself and other nuclear chromatin-associated proteins. PARP-1 knockout mice are protected against myocardial infarction, streptozotocin-induced diabetes, lipopolysaccharide-induced septic shock, and zymosan-induced multiple organ failure, indicating that PARP-1 is involved in the regulation of the pathogenesis of these disorders. PARP-1 and nuclear factor kappa B (NF-kappaB) have both been suggested to play a crucial role in inflammatory disorders. NF-kappaB encompasses a family of inducible transcription factors which play a crucial role in the regulation of genes involved in immune and inflammatory responses. Recent reports have shown that PARP-1 can act as a coactivator of NF-kappaB. These findings might provide new insights into the pathophysiology of different diseases such as type I diabetes and septic shock. The purpose of this review is to give a short overview of the current knowledge about PARP-1 and its functional and biochemical interactions with NF-kappaB. A more precise role for PARP-1 in NF-kappaB-dependent gene regulation and cellular metabolism during development of pathophysiological processes is discussed. Special considerations is given to the pathophysiological significance of these findings in terms of inflammatory disorders.

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“…Of the anti‐inflammatory drugs in use, NSAID can not prevent the progression of chronic inflammation. This group is able to affect cytokine synthesis by human monocytes stimulated by TPA at high concentrations only ( Jiang et al ., 1998 ), and in addition, the inhibition of PG synthesis can potentiate the expression of TNFα induced by LPS ( Bondeson & Sundler, 1996 ). Glucocorticoids are potent agents for the treatment of chronic inflammatory diseases, although severe side effects limit the long term administration required in chronic disorders.…”

Section: Discussionmentioning

confidence: 99%

Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A₂

Pastor

Rosa

Giulio

et al. 1999

British J Pharmacology

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1 Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa. In in vitro studies, this compound inhibited phospholipase A 2 (PLA 2 ), showing selectivity for secretory PLA 2 (sPLA 2 ) versus cytosolic PLA 2 (cPLA 2 ), and its potency on the human synovial enzyme (group II) was similar to that of manoalide. 2 This activity was con®rmed in vivo in the 8 h zymosan-injected rat air pouch, on the secretory enzyme accumulating in the pouch exudate. Cacospongionolide B, that is bioavailable when is given orally, reduced the elevated levels of sPLA 2 present in paw homogenates of rats with adjuvant arthritis. 3 This marine metabolite showed topical anti-in¯ammatory activity on the mouse ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA) and decreased carrageenin paw oedema in mice after oral administration of 5, 10 or 20 mg kg 71. 4 In the mouse air pouch injected with zymosan, cacospongionolide B administered into the pouch, induced a dose-dependent reduction in the levels of eicosanoids and tumour necrosis factor a (TNFa) in the exudates 4 h after the stimulus. It also had a weak eect on cell migration. 5 The in¯ammatory response of adjuvant arthritis was reduced by cacospongionolide B, which did not signi®cantly aect eicosanoid levels in serum, paw or stomach homogenates and did not induce toxic eects. 6 Cacospongionolide B is a new inhibitor of sPLA 2 in vitro and in vivo, with anti-in¯ammatory properties in acute and chronic in¯ammation. This marine metabolite was active after oral administration and able to modify TNFa levels, and may oer an interesting approach in the search for new anti-in¯ammatory agents.

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Differential effects of tenidap on the zymosan- and lipopolysaccharide-induced expression of mrna for proinflammatory cytokines in macrophages

Cited by 16 publications

References 24 publications

Suppression of leukotriene B4 and tumour necrosis factor α release in acute inflammatory responses by novel prenylated hydroquinone derivatives

Suppression of leukotriene B4 and tumour necrosis factor α release in acute inflammatory responses by novel prenylated hydroquinone derivatives

The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-κB in inflammatory disorders

Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A₂

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Differential effects of tenidap on the zymosan- and lipopolysaccharide-induced expression of mrna for proinflammatory cytokines in macrophages

Cited by 16 publications

References 24 publications

Suppression of leukotriene B4 and tumour necrosis factor α release in acute inflammatory responses by novel prenylated hydroquinone derivatives

Suppression of leukotriene B4 and tumour necrosis factor α release in acute inflammatory responses by novel prenylated hydroquinone derivatives

The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-κB in inflammatory disorders

Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2

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Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A₂