Differential effects of tactile high- and low-frequency stimulation on tactile discrimination in human subjects

Ragert, Patrick; Kalisch, Tobias; Bliem, Barbara; Franzkowiak, Stephanie; Dinse, Hubert R.

doi:10.1186/1471-2202-9-9

Cited by 77 publications

(133 citation statements)

References 29 publications

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“…S1). Moreover, in recent experiments on changes in tactile acuity after coactivating fingers of the right, dominant hand, measurable changes of acuity of the left, nonstimulated hand had never been observed (22,23,(25)(26)(27)(28)(29), which argues for a substantial locality of coactivation-induced changes and supports the view that after repeated testing, RT effects are due to practice.…”

Section: Resultssupporting

confidence: 51%

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Cortical topography of intracortical inhibition influences the speed of decision making

Wilimzig

Ragert

Dinse

2012

Proc. Natl. Acad. Sci. U.S.A.

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The neocortex contains orderly topographic maps; however, their functional role remains controversial. Theoretical studies have suggested a role in minimizing computational costs, whereas empirical studies have focused on spatial localization. Using a tactile multiple-choice reaction time (RT) task before and after the induction of perceptual learning through repetitive sensory stimulation, we extend the framework of cortical topographies by demonstrating that the topographic arrangement of intracortical inhibition contributes to the speed of human perceptual decisionmaking processes. RTs differ among fingers, displaying an inverted U-shaped function. Simulations using neural fields show the inverted U-shaped RT distribution as an emergent consequence of lateral inhibition. Weakening inhibition through learning shortens RTs, which is modeled through topographically reorganized inhibition. Whereas changes in decision making are often regarded as an outcome of higher cortical areas, our data show that the spatial layout of interaction processes within representational maps contributes to selection and decisionmaking processes.computational neuroscience | plasticity | cortical reorganization T he mammalian neocortex contains orderly topographic maps of receptor surfaces that emerge early during ontogenetic development (1, 2). However, the functional meaning and relevance of the topographical arrangement are still debated (1-5). There is agreement that topographic mapping is instrumental in minimizing computational costs by keeping the length of axonal and dendritic wiring low, thereby contributing to the compactness of the neural circuitry (1, 6-8). On the other hand, experimental studies have focused on the extent and size of topographic maps, thereby exploring how and where physical stimuli and their attributes are localized and represented in the brain. Cortical lateral interaction seems to play a crucial role in the integration of information from remote skin portions, which is required for localization and discrimination (9-11), contour integration, as well as contextual influences by surrounding elements (12, 13). Accordingly, cortical processing is modulated by nonlinear interactions through range-dependent intracortical excitation and inhibition. The mean-field approach has been shown to provide an adequate and elegant way to model the collective properties of large numbers of interacting neurons (14-16).Decision making has been discussed in the context of contributions of frontal and prefrontal cortical areas (17)(18)(19)(20). Our study provides an extension of the framework of cortical topographies by demonstrating through a combination of psychophysics, plasticity, and modeling that the speed of perceptual decision making is modulated by the topographic layout of intracortical interactions within early sensory cortical areas. We used a tactile multiple-choice reaction time (RT) task that requires selecting a given finger out of all 10 fingers on both hands ( Fig. 1) (21). RTs strongly differ among indivi...

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Section: Resultssupporting

confidence: 51%

“…Coactivation is a form of repetitive sensory stimulation based on the induction of presumably Hebbian learning mechanisms (24)(25)(26). Coactivation has been shown to expand cortical finger representation (27,28) and to reduce intracortical inhibition, as indicated by reduced paired-pulse inhibition (29).…”

mentioning

confidence: 99%

Cortical topography of intracortical inhibition influences the speed of decision making

Wilimzig

Ragert

Dinse

2012

Proc. Natl. Acad. Sci. U.S.A.

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“…After 20 minutes of burst stimulation, a decrease of the 2PD threshold between 5 % (Schlieper & Dinse, 2012;Tossi et al, 2013) and 16 % (Ragert et al, 2008) was found.…”

Section: Cortical Excitabilitymentioning

confidence: 99%

“…Indeed, in humans, the induced cortical changes were associated with changes in tactile perceptual abilities comparable to those occurring after application of active perceptual learning paradigms. Since then, many studies that used different variants of tactile stimulation interventions, revealed supportive evidence that induced cortical changes rely on hebbian like processes (Beste & Dinse, 2013;Ragert, Kalisch, Bliem, Franzkowiak, & Dinse, 2008). Furthermore it could be shown that, as for the induction of LTD and LTP, the temporal pattern and frequency of tactile stimulation protocols were decisive for the found effects in terms of neural excitability, cortical topography, as well as tactile performance (Beste & Dinse, 2013;Dinse et al, 1996;Kalisch, Tegenthoff, & Dinse, 2007).…”

Section: Introduction-what Is Repetitive Tactile Stimulation and Whermentioning

confidence: 99%

“…Irrespective of the stimulated body parts, the area of stimulation needs to be sufficiently large to make sure that afferents with separated receptive fields are stimulated synchronously. By comparison, rTS on only a single -point-like‖ location of the skin has been found to be insufficient to induce plastic changes Ragert et al, 2008).Besides tactile stimulation, direct transcutaneous electrical stimulation (TENS ) of the median, peroneal, radial PARAMETER CHOICE AND EFFECTIVENESS OF TACTILE STIMULATION 8 and/or the ulnar nerve, respectively, was applied, thus providing simultaneous activation of a broad population of the sensory afferents themselves with non-overlapping and (partly) overlapping receptive fields. Although this is not tactile stimulation in the proper sense, rationales behind and induced effects are similar.…”

Section: Different Stimulation Protocolsmentioning

confidence: 99%

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Tactile stimulation interventions: Influence of stimulation parameters on sensorimotor behavior and neurophysiological correlates in healthy and clinical samples

Lesemann

Reuter

Godde

2015

Neuroscience & Biobehavioral Reviews

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Impact of anesthesia exposure in early development on learning and sensory functions

Aksenov

Miller

Dixon

et al. 2020

Developmental Psychobiology

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Each year, millions of children undergo anesthesia, and both human and animal studies have indicated that exposure to anesthesia at an early age can lead to neuronal damage and learning deficiency. However, disorders of sensory functions were not reported in children or animals exposed to anesthesia during infancy, which is surprising, given the significant amount of damage to brain tissue reported in many animal studies. In this review, we discuss the relationship between the systems in the brain that mediate sensory input, spatial learning, and classical conditioning, and how these systems could be affected during anesthesia exposure. Based on previous reports, we conclude that anesthesia can induce structural, functional, and compensatory changes in both sensory and learning systems. Changes in myelination following anesthesia exposure were observed as well as the neurodegeneration in the gray matter across variety of brain regions. Disproportionate cell death between excitatory and inhibitory cells induced by anesthesia exposure can lead to a long‐term shift in the excitatory/inhibitory balance, which affects both learning‐specific networks and sensory systems. Anesthesia may directly affect synaptic plasticity which is especially critical to learning acquisition. However, sensory systems appear to have better ability to compensate for damage than learning‐specific networks.

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Differential effects of tactile high- and low-frequency stimulation on tactile discrimination in human subjects

Cited by 77 publications

References 29 publications

Cortical topography of intracortical inhibition influences the speed of decision making

Cortical topography of intracortical inhibition influences the speed of decision making

Tactile stimulation interventions: Influence of stimulation parameters on sensorimotor behavior and neurophysiological correlates in healthy and clinical samples

Impact of anesthesia exposure in early development on learning and sensory functions

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