Differential effects of social isolation in adolescent and adult mice on behavior and cortical gene expression

Lander, Sharon S; Linder-Shacham, Donna; Gaisler‐Salomon, Inna

doi:10.1016/j.bbr.2016.09.005

Cited by 70 publications

(62 citation statements)

References 93 publications

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“…These results indicate that the short post‐weaning social isolation induces an increase in response to a challenge with DEP. These findings are in agreement with other studies that evidenced increased locomotor activity AMPH‐dependent in animals that were previous socially isolated (Herrmann et al, 2014; Lander et al, 2017; Lomanowska et al, 2010). A possible limitation in this experiment would be the possibility of a ceiling effect, as suggested by some authors (Cain et al, 2008; Mathews et al, 2010).…”

Section: Discussionsupporting

confidence: 93%

“…These results are in agreement with Arakawa (2003), that observed a reduced in number of crossings in SI animals (PD26‐40) when analyzed shortly after isolation (Arakawa, 2003). Moreover, a few other studies that evaluated short periods of post‐weaning social isolation (until 3 weeks of SI) observed no differences in locomotor activity (Ishihama et al, 2010; Lander et al, 2017; Lukkes et al, 2012; Paulus et al, 1998) compared with grouped animals. These findings are contrary to others studies that have reported an increase in locomotor activity in SI animals (Haupt and Schaefers, 2010; Hickey et al, 2012; Ko and Liu, 2015; Simpson et al, 2010; Varty et al, 2000), however, the majority of those studies analyzed long periods of social isolation (more than 6 weeks).…”

Section: Discussionmentioning

confidence: 95%

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Short post‐weaning social isolation induces long‐term changes in the dopaminergic system and increases susceptibility to psychostimulants in female rats

Lampert

Arcego

Couto-Pereira

et al. 2017

Intl J of Devlp Neuroscience

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Childhood and adolescence are sensitive periods of development, marked by high brain maturation and plasticity. Exposure to early life stress, such as social isolation, is able to prompt changes in sensitive brain circuitries, essentially in the mesolimbic dopaminergic system and increase the risk for addictive behaviors later in life. Post-weaning social isolation can stimulate the consumption of rewarding substances, like drugs of abuse and palatable foods. However, most studies analyze long periods of social isolation and very little is known about the effects of a brief social isolation in a sensitive period of development and its association with palatable food on the reward system sensitization. Furthermore, females are more susceptible to the reinforcing effect of drugs than males. Therefore, the aim of this study was to analyze the effects of a short post-weaning social isolation combined with a free access to a chronic high sugar diet (HSD) on the dopaminergic system, oxidative status and behavioral response to an amphetamine-like drug in adulthood. We used female Wistar rats that were socially isolated from post-natal days (PD) 21 to 35 and received free access to a HSD until PD 60. On PD 65, animals were submitted to a challenge with diethylpropion (DEP), an amphetamine-like drug and different responses were analyzed: locomotor activity, immmunocontent of dopamine related proteins, and the oxidative status in the striatum, before and after the DEP challenge. We showed that a short post-weaning social isolation (SI) increased the locomotor response to DEP, when compared with previous saline administration. Social isolation also increased dopamine transporter, tyrosine hydroxylase, and decreased dopamine D2 receptor immunocontent. Additionally, SI increased the overall oxidative status parameters after the challenge with DEP. Interestingly, the exposure to a HSD prevented the SI effects on locomotor response, but did not interfere in the dopaminergic parameters evaluated, despite having modified some oxidative parameters. This study showed for the first time that a short post-weaning social isolation was able to induce long-term changes in the striatal dopaminergic system and increased the response to psychostimulants. These results emphasize the importance of stressful experiences during a short period of development on programming susceptibility to psychostimulants later in life.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Short post‐weaning social isolation induces long‐term changes in the dopaminergic system and increases susceptibility to psychostimulants in female rats

Lampert

Arcego

Couto-Pereira

et al. 2017

Intl J of Devlp Neuroscience

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“…In adolescence, following the juvenile neuronal proliferation, the brain rewires itself from the onset of puberty up until 24 years old, especially in the prefrontal cortex (Arain et al, 2013). Depriving mice of social contact and play during midadolescence dysregulates prefrontal cortex function, resulting in altered social behaviour and impairing learning, attention and cognitive flexibility (Lander, Linder-Shacham, & Gaisler-Salomon, 2017). Taking this even further, when late adolescent (adult) rats are deprived of physical interaction with other rats, like rough-and-tumble play, they become depressed (Burgdorf et al, 2017) and do not possess the social skills to separate appropriate from inappropriate aggression .…”

Section: Social Intelligencementioning

confidence: 99%

The physiology of play: potential relevance for higher education

Koeners

Francis

2020

International Journal of Play

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This paper explores the physiology of play and its potential for advancing higher education through promoting joy and counteracting performativity, which we argue is a proponent of mental ill-health in the sector. Although play is increasingly recognised as a fundamental part of the human experience and a successful teaching practice, it is only consistently applied within childhood education. We identify 3 key areas of play physiology relevant for higher education: physical and mental resilience; social intelligence; cognitive flexibility and intellect. We conclude that the incorporation of play within higher education by developing 'Playful Universities' could counteract the fear of failing, avoidance of risk and other negative aspects of performativity and goaloriented behaviour. Playful learning, therefore, challenges the continued relevance of focusing on a dehumanising and oppressive neoliberal model of performativity-based learning and sheds light on the potential of a joyous, authentic transition to the co-creation of knowledge within higher education. ARTICLE HISTORY

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“…In contrast, mice in the current study were individually housed from weaning onwards and experienced post-weaning growth impairments. The consequences of social isolation stress for brain function in rodents are known to be dependent on the life stage during which isolation takes place (24). Similarly, the metabolic consequences of individual housing may also be modulated by the life stage during which individual housing takes place.…”

Section: Discussionmentioning

confidence: 99%

“…Due to critical steps in brain and endocrine development that take place in the period between weaning and sexual maturation, adolescence represents a period of heightened vulnerability to social isolation stress in rodents (21). Indeed, profound abnormalities in brain structural and functional development due to social isolation occur specifically during adolescence, disrupting cognitive and behavioural function at later life stages (22–24). Adolescence is also a period of rapid lean body growth (25), which is accompanied by a high energy demand.…”

Section: Introductionmentioning

confidence: 99%

Individual housing of male C57BL/6J mice after weaning impairs growth and predisposes for obesity

Schipper

Heijningen

Karapetsas

et al. 2019

Preprint

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11Individual housing from weaning onwards resulted in reduced growth rate during adolescence in male 12 C57Bl/6J mice that were housed individually, while energy intake and energy expenditure were 13 increased compared to socially housed counterparts. At 6 weeks of age, these mice had reduced lean 14 body mass, but significantly higher white adipose tissue mass compared to socially housed mice. Body 15 weight gain of individually housed animals exceeded that of socially housed mice during adulthood, 16 with elevations in both energy intake and expenditure. At 18 weeks of age, individually housed mice 17 showed higher adiposity and higher mRNA expression of UCP-1 in inguinal white adipose tissue. 18Exposure to an obesogenic diet starting at 6 weeks of age further amplified body weight gain and 19 adipose tissue deposition. This study shows that post-weaning individual housing of male mice results 20 in impaired adolescent growth and higher susceptibility to obesity in adulthood. Mice are widely used 21 to study obesity and cardiometabolic comorbidities. For (metabolic) research models using mice,

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Differential effects of social isolation in adolescent and adult mice on behavior and cortical gene expression

Cited by 70 publications

References 93 publications

Short post‐weaning social isolation induces long‐term changes in the dopaminergic system and increases susceptibility to psychostimulants in female rats

Short post‐weaning social isolation induces long‐term changes in the dopaminergic system and increases susceptibility to psychostimulants in female rats

The physiology of play: potential relevance for higher education

Individual housing of male C57BL/6J mice after weaning impairs growth and predisposes for obesity

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