Differential effects of sevoflurane on the metastatic potential and chemosensitivity of non-small-cell lung adenocarcinoma and renal cell carcinoma in vitro

Ciechanowicz, S.; Zhao, Hailin; Chen, Qiquan; Cui, Jiang; Mi, Emma; Lian, Qingquan; Ma, Ding

doi:10.1016/j.bja.2017.11.066

Cited by 56 publications

(49 citation statements)

References 23 publications

(25 reference statements)

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“…Furthermore, co-treatment with sevoflurane and the chemotherapeutic agent cisplatin caused synergistic growth inhibitory and anti-invasive effects (17). However, in another study, the incubation of A549 cells with 3.6vol% sevoflurane for 2 h reduced cell proliferation and increased chemosensitivity but did not affect migration (18). Interestingly, in the same study, the viability and metastatic potential, as well as the chemoresistance, of renal cell carcinoma cells was enhanced (18).…”

Section: Discussionmentioning

confidence: 90%

“…However, in another study, the incubation of A549 cells with 3.6vol% sevoflurane for 2 h reduced cell proliferation and increased chemosensitivity but did not affect migration (18). Interestingly, in the same study, the viability and metastatic potential, as well as the chemoresistance, of renal cell carcinoma cells was enhanced (18). Kvolik et al showed increased apoptosis induced by sevoflurane in Caco 2 colon cancer cells but only moderate effects in laryngeal cancer cells (19).…”

Section: Discussionmentioning

confidence: 91%

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Effects of Volatile Anesthetics on Proliferation and Viability of SW480 Colon Cancer Cells In Vitro

et al. 2019

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Background/Aim: For patients undergoing cancer surgery, the risk for cancer progression is enhanced during the perioperative period. To what extent the type of anesthetic can affect the metastatic process and finally the outcome of patients with cancer is under debate. For this reason, the aim of this study was to investigate the effects of the volatile anesthetics sevoflurane and desflurane on colon cancer cells in vitro. Materials and Methods: SW480 colon carcinoma cells were exposed for 3 or 6 h to sevoflurane (1 or 2.5 vol%) or desflurane (6 or 12 vol%). Cell cycle distribution was analyzed by flow cytometry after a 24-72 h recovery and apoptosis was detected by annexin V staining after a 0-48 h recovery. Viability was tested by measuring ATP content after 0 and 24 h recovery. Results: Treatment with sevoflurane or desflurane caused no or only slight changes in cell-cycle distribution and apoptosis rate. Desflurane at 12vol% significantly reduced cell viability by 17±25% and 11±22% after 3 and 6 h incubation and 24 h recovery, respectively, while 2.5 vol% sevoflurane slightly increased viability. Conclusion: At clinically relevant concentrations, sevoflurane and desflurane had only slight effects on SW480 colon cancer cells in vitro.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 91%

Effects of Volatile Anesthetics on Proliferation and Viability of SW480 Colon Cancer Cells In Vitro

et al. 2019

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“…Yang et al (7) simulated the effects of clinical use of Sevo on colon cancer cells in vitro and found that Sevo inhibited tumor cell growth and induced apoptosis. In contrast, several preclinical studies reported that Sevo could promote breast cancer growth and enhances renal cancer survival (8,9). However, few studies have addressed the influence of Sevo on HCC; therefore, this study explored the role of Sevo on the various biological aspects of HCC cells.…”

Section: Introductionmentioning

confidence: 97%

Sevoflurane inhibits the proliferation and invasion of hepatocellular carcinoma cells through regulating the PTEN/Akt/GSK‑3β/β‑catenin signaling pathway by downregulating miR‑25‑3p

Cao

Ding

et al. 2020

Int J Mol Med

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Sevoflurane (Sevo) is one of the most frequently used volatile anesthetic agents in surgical oncology and has various effects on tumors, including inhibiting tumor growth, recurrence, and metastases; however, the molecular mechanisms are unknown. This study tried to investigate the influence of Sevo on hepatocellular carcinoma (HCC) cells and its possible mechanisms of action. The present study found that Sevo suppressed both the proliferative and invasive capabilities of both HCCLM3 and Huh7 cells in a dose-dependent manner. Moreover, 53 differentially expressed microRNAs (miRNAs/miRs) in HCC cells that resulted from Sevo were screened out using miRNA microarray assay. In particular, miR-25-3p displayed a significant decrease in response to Sevo treatment. Further studies showed that Sevo's inhibitory actions on HCC cells were attenuated by overexpression of miR-25-3p but enhanced by its inhibitor. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN), a tumor suppressor gene, was directly targeted by miR-25-3p and its expression was upregulated by Sevo. In addition, Sevo suppressed the expression of phosphorylated-protein kinase B (p-Akt) (S473), glycogen synthase kinase (GSK) 3β (p-GSK3β) (S9), β-catenin, c-Myc and matrix metalloproteinase 9; whereas these inhibitory effects were reversed by miR-25-3p overexpression. More importantly, Sevo's tumor-suppressive effects were enhanced by LY294002 (a PI3-kinase inhibitor) but weakened by insulin growth factor-1 (an agonist of the Akt signaling pathway). These data suggest that Sevo's antitumor effects on HCC could be explained, in part, by Sevo inhibiting the miR-25-3p/PTEN/Akt/GSK-3β/β-catenin signaling pathway.

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“…17 In addition, another study uncovered that upregulated transforming growth factor-beta (TGF-β) and osteopontin signaling pathways played pivotal roles in sevoflurane-mediated renal cell carcinoma (RCC) metastasis potential. 25 In an in vivo study, one group revealed that sevoflurane increased tumor volume and invasion/migration distance in nude mice compared with the group without sevoflurane 24 (Table 1, Figure 1).…”

Section: The Biological Function Of Sevoflurane In Promoting Oncogenesismentioning

confidence: 97%

“…28 In line with this, another group showed that sevoflurane combined with cisplatin led to a greater extent suppression of human lung adenocarcinoma cells' growth in comparison with sevoflurane or cisplatin alone, which might also be related to the downregulation of XIAP and survivin protein. 29 Notably, microRNA (miRNA)-203 was upregulated by sevoflurane and mediated the function of sevoflurane in Upregulates CD44 Promotes glioblastoma cell migration and invasion [24] Upregulates TGF-β and osteopontin Induces RCC cells metastasis [25] Suppresses oncogenesis Downregulates p-Akt and Bcl-2 Inhibits neck squamous cell cancer cell proliferation [27] Upregulates Fas/FasL Induces HNSCC cells apoptosis [27] Downregulates XIAP, survivin and upregulates caspase-3…”

Section: The Biological Function Of Sevoflurane In Suppressing Oncogementioning

confidence: 99%

<p>The Role of Inhaled Anesthetics in Tumorigenesis and Tumor Immunity</p>

Xu¹,

Jiang²,

Xie³

et al. 2020

CMAR

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Inhaled anesthetics are widely used for induction and maintenance of anesthesia during surgery, including isoflurane, sevoflurane, desflurane, haloflurane, nitrous oxide (N 2 O), enflurane and xenon. Nowadays, it is controversial whether inhaled anesthetics may influence the tumor progression, which urges us to describe the roles of different inhaled anesthetics in human cancers. In the review, the relationships among the diverse inhaled anesthetics and patient outcomes, immune response and cancer cell biology were discussed. Moreover, the mechanisms of various inhaled anesthetics in the promotion or inhibition of carcinogenesis were also reviewed. In summary, we concluded that several inhaled anesthetics have different immune functions, clinical outcomes and cancer cell biology, which could contribute to opening new avenues for selecting suitable inhaled anesthetics in cancer surgery.

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Differential effects of sevoflurane on the metastatic potential and chemosensitivity of non-small-cell lung adenocarcinoma and renal cell carcinoma in vitro

Cited by 56 publications

References 23 publications

Effects of Volatile Anesthetics on Proliferation and Viability of SW480 Colon Cancer Cells In Vitro

Effects of Volatile Anesthetics on Proliferation and Viability of SW480 Colon Cancer Cells In Vitro

Sevoflurane inhibits the proliferation and invasion of hepatocellular carcinoma cells through regulating the PTEN/Akt/GSK‑3β/β‑catenin signaling pathway by downregulating miR‑25‑3p

<p>The Role of Inhaled Anesthetics in Tumorigenesis and Tumor Immunity</p>

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