Differential effects of selenium compounds on glucose synthesis in rabbit kidney-cortex tubules and hepatocytes. In vitro and in vivo studies

Kiersztan, Anna; Lukasinska, I.; Barańska, Anna; Lebiedzińska, Magdalena; Nagalski, Andrzej; Derlacz, Rafał; Bryła, Jadwiga

doi:10.1016/j.jinorgbio.2006.11.012

Cited by 15 publications

(7 citation statements)

References 77 publications

(97 reference statements)

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“…What is the exact impact of Se supplementation on glucose homeostasis and the risk of diabetes remains still an open question. The answer will not be obtained without studies unraveling the underlying mechanisms, as well as factors which may modify Se effects with respect to glucose homeostasis, in addition to these already suggested, such as sex and genotype [50,51], as well as Se speciation [52,53]. Explaining the link between Se, glucose metabolism, and diabetes is currently one of the priority goals in Se research because it will determine the further direction of studies focusing on Se as a potential chemopreventive agent.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

et al. 2016

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The aim of the study was to evaluate the effect of selenium supplementation on the expression of genes associated with glucose metabolism in humans, in order to explain the unclear relationship between selenium and the risk of diabetes. For gene expression analysis we used archival samples of cDNA from 76 non-diabetic subjects supplemented with selenium in the previous study. The supplementation period was six weeks and the daily dose of selenium was 200 µg (as selenium yeast). Blood for mRNA isolation was collected at four time points: before supplementation, after two and four weeks of supplementation, and after four weeks of washout. The analysis included 15 genes encoding selected proteins involved in insulin signaling and glucose metabolism. In addition, HbA1c and fasting plasma glucose were measured at three and four time points, respectively. Selenium supplementation was associated with a significantly decreased level of HbA1c but not fasting plasma glucose (FPG) and significant down-regulation of seven genes: INSR, ADIPOR1, LDHA, PDHA, PDHB, MYC, and HIF1AN. These results suggest that selenium may affect glycemic control at different levels of regulation, linked to insulin signaling, glycolysis, and pyruvate metabolism. Further research is needed to investigate mechanisms of such transcriptional regulation and its potential implication in direct metabolic effects.

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Section: Discussionmentioning

confidence: 99%

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

et al. 2016

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“…Se deficiency is reported to be involved in the development of a number of diseases such as cancer (Rayman, 2000), Keshan disease, an endemic cardiomyopathy, Kashin–Beck disease, a deforming arthritis (Reilly, 1996). Moreover, several studies using inorganic and organic forms of Se have demonstrated their protective effects against oxidative stress in disease models of diabetes (Kiersztan et al, 2007), cancer (Steinbrenner and Sies, 2009) and neurological disorders (Atif et al, 2008). In fact, different classes of Se compounds such as Ebselen, a lipid soluble seleno‐organic compound, (Porciúncula et al, 2001), as well as other organic Se (Nogueira et al, 2004; Fachinetto et al, 2007) and inorganic Se such as sodium selenite (Atif et al, 2008) exhibit a neuroprotective role via their antioxidant properties, making Se an essential trace element.…”

Section: Introductionmentioning

confidence: 99%

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

Amara

Fetoui

Guermazi

et al. 2009

Intl J of Devlp Neuroscience

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The aim of this study is to investigate the improving effects of selenium (Se) on cerebrum and cerebellum impairments induced by methimazole (MMI) in suckling rats. Animals were randomly divided into four groups of six each: group I served as control which received standard diet; group II received only MMI (250 mg L(-1)(,) orally); group III received both MMI (250 mg L(-1), orally) and Se (0.5 mg kg(-1) of diet); group IV served as a positive control and received Se (0.5 mg kg(-1) of diet) as sodium selenite (Na(2)SeO(3)). Treatments were started from the 14th day of pregnancy until day 14 after delivery. In the MMI-treated group, plasma-free thyroid hormone levels (FT(3) and FT(4)), protein, DNA and RNA contents in cerebrum and cerebellum decreased when compared to control. Co-treatment with Se ameliorated these parameters. In the MMI-treated group, antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) significantly decreased, while malonaldialdehyde (MDA) levels in cerebrum and cerebellum increased. Co-administration of Se through the diet restored these parameters to near normal values. The biochemical modifications are correlated histologically with the abnormal development of an external granular layer, indicating a delay of granular cells migration towards the molecular layer in the MMI-treated group. Our results showed that Se improved cerebrum and cerebellum MMI-induced damages in suckling rats. Moreover, we concluded that Se is an important neuroprotective element that may be used as a dietary supplement against brain impairments.

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“…Animal studies have indicated that Se supplementation may lead to hyperinsulinemia, insulin resistance, and glucose intolerance [37]. Kiersztan et al reflected the different effect of inorganic (sodium selenite) and organic form (methylselenocysteine) on glucose homeostasis [38]. Different effects can be expected for various selenium nano forms.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sub-Lethal Doses of Selenium Nanoparticles on the Health Status of Rats

Urbánková

Skaličková

Přibilová

et al. 2021

Toxics

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Selenium nanoparticles (SeNPs) are fast becoming a key instrument in several applications such as medicine or nutrition. Questions have been raised about the safety of their use. Male rats were fed for 28 days on a monodiet containing 0.5, 1.5, 3.0 and 5.0 mg Se/kg. Se content in blood and liver, liver panel tests, blood glucose, total antioxidant capacity (TAC), the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were analysed. Liver and duodenum were subjected to histopathology examination. The weight gain of rats showed no differences between tested groups. Se content in blood was higher in all treated groups compared to the control group. The liver concentration of Se in the treated groups varied in the range from 222 to 238 ng/g. No differences were observed in the activity of AST (aspartate aminotransferase), ALP (alkaline phosphatase) and TAS (total antioxidant status). A significant decrease in ALT activity compared to the control group was observed in the treated groups. GPx activity varied from 80 to 88 U/mL through tested groups. SOD activity in liver was decreased in the SeNP-treated group with 5 mg Se/kg (929 ± 103 U/mL). Histopathological examination showed damage to the liver parenchyma and intestinal epithelium in a dose-dependent manner. This study suggests that short-term SeNP supplementation can be safe and beneficial in Se deficiency or specific treatment.

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Differential effects of selenium compounds on glucose synthesis in rabbit kidney-cortex tubules and hepatocytes. In vitro and in vivo studies

Cited by 15 publications

References 77 publications

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

Effects of Sub-Lethal Doses of Selenium Nanoparticles on the Health Status of Rats

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