Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology

Linneberg, Allan; Simonsen, Jacob; Petersen, Janne; Stensballe, Lone Graff; Benn, Christine Stabell

doi:10.1016/j.jaci.2005.09.042

Cited by 87 publications

(91 citation statements)

References 17 publications

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“…(13,22) In our study, having parents or siblings with asthma translated to a 20% higher risk of wheezing in the first year of life. The risk of wheezing was found to be similar in male and female infants.…”

Section: Discussionmentioning

confidence: 60%

“…However, no association was found between postnatal exposure to smoking in the household and the risk of wheezing. In a large birth cohort study of children in Denmark, (22) maternal or paternal smoking, in combination with a history of asthma in the nuclear family, tripled the risk of wheezing, compared with a history of asthma in the nuclear family alone.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, in a cohort in the city of Rio Grande, Brazil, (12) the risk of wheezing was 30-40% higher among children whose family members smoked. In the birth cohort study of children in Denmark, (22) the authors observed that maternal smoking during pregnancy was also related to wheezing in the first years of life, although not to atopic disease. Another group of authors, (27) studying a population with characteristics similar to those of our study population, found that, after a multifactorial analysis, only maternal smoking during pregnancy was associated with wheezing in the first year of life.…”

Section: Discussionmentioning

confidence: 99%

“…(23) Day care center attendance was associated with a nearly 30% higher risk of wheezing. In some studies, (22,24) involving populations in European countries, there was also an association between day care center attendance and the The objective of a large population-based study, such as the EISL, is to assess potential differences among populations with different socioeconomic and cultural characteristics, and this makes it necessary to wait for a larger amount of data from the various centers participating in the study so that comparisons and analysis can be made. Based on the results of present study, we can conclude that there is a high prevalence of wheezing among infants residing in the city of Porto Alegre, Brazil, and that there is significant related morbidity.…”

Section: Discussionmentioning

confidence: 99%

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Prevalência e fatores de risco para sibilância no primeiro ano de vida

et al. 2010

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Objective: To determine the prevalence of and the risk factors for wheezing in infants under one year of age and residing in the city of Porto Alegre, Brazil. Methods: This was a cross-sectional study and is part of a multicenter, multinational project. The parents or legal guardians of the infants were interviewed at primary health care clinics or during home visits. We used a standardized questionnaire, validated for use in Brazil. Potential risk factors were assessed by means of a Poisson regression model with robust variance estimation, using the Wald test to determine the significance of each variable in the model. Results: The sample comprised 1,013 infants. The majority of those were male (53%), and the mean age was 13.5 ± 1.2 months. In 61% of the infants, there had been at least one episode of wheezing, which had recurred at least three times in one third of those infants. The mean age at the first episode of wheezing was 5.16 months (median, 5 months). Over 40% of the infants with wheezing visited emergency rooms due to wheezing, and 17% of those were hospitalized at least once in the first year of life because of this symptom. In the multivariate analysis, the risk factors for wheezing were as follows: male gender; history of pneumonia; maternal smoking during pregnancy; day care center attendance; low maternal level of education; early weaning; multiple episodes of cold; first viral infection prior to 3 months of age; existence of siblings; and history of asthma in the nuclear family. Conclusions: The prevalence of wheezing is high among infants in the city of Porto Alegre. We identified various risk factors for wheezing in infants.Keywords: Respiratory sounds/epidemiology; Asthma; Infant; Risk factors. ResumoObjetivo: Determinar a prevalência e os fatores de risco para sibilância em lactentes com até um ano de idade e residentes na cidade de Porto Alegre (RS). Métodos: Estudo transversal, parte de um projeto multicêntrico e multinacional. Os pais ou responsáveis dos lactentes foram entrevistados em unidades básicas de saúde ou durante visitas domiciliares. Utilizamos um questionário padronizado e validado para uso no Brasil. Potenciais fatores de risco foram avaliados mediante um modelo de regressão de Poisson com estimativa robusta de variância, utilizando-se o teste de Wald para determinar a significância de cada variável no modelo. Resultados: Foram incluídos 1.013 lactentes. A maioria era do sexo masculino (53%), e a média de idade foi de 13,5 ± 1,2 meses. Houve pelo menos um episódio de sibilância em 61% dos lactentes, e houve recorrência do sintoma em pelo menos três ocasiões em um terço daqueles lactentes. A média de idade no início dos episódios de sibilância foi de 5,16 meses (mediana, 5 meses). Mais de 40% dos lactentes com sibilância visitaram serviços de urgência em função desse sintoma, e 17% tiveram pelo menos uma hospitalização por essa causa no primeiro ano de vida. Na análise multivariada, os fatores de risco para sibilância foram os seguintes: sexo masculino, história de pn...

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalência e fatores de risco para sibilância no primeiro ano de vida

et al. 2010

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“…'Recurrent wheeze' defined as at least four wheeze episodes was used to identify our cases. 10,11 We used this definition because it is difficult to diagnose asthma in infants, no international consensus is available and the strategy of the individual physician can influence diagnose. 1 Participants were selected among the DNBC individuals according to the following criteria: expected delivery within Greater Copenhagen, wheeze episodes at 18 months of age and availability of blood sample from the child (11 942 participants).…”

Section: Methodsmentioning

confidence: 99%

Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze

et al. 2011

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The first common genetic factor identified for pediatric asthma by genome-wide association is the chromosome 17q21 locus, harbouring the ORMDL3 gene. ORMDL3 is involved in facilitation of endoplasmic reticulum-mediated inflammatory responses, believed to underlie its asthma association. We investigated associations between the rs7216389 polymorphism in the 17q21 locus affecting ORMDL3 expression and the risk for recurrent wheeze and interactions with exposure to tobacco smoke and furred pets during pregnancy and infancy using a birth cohort of 101 042 infants. Rs7216389 was significantly associated with recurrent wheeze risk among 18-month-old infants. There was a 1.35-fold higher risk of recurrent wheeze among homozygous variant allele carriers compared with homozygous wild-type allele carriers. There was significant interaction between rs7216389 and domestic furred pets, with a positive association between pets and wheeze among homozygous wild-type carriers and a negative association among homozygous variant allele carriers. There was no interaction between rs7216389 and tobacco smoke exposure.

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Incidence Trends of Atopic Dermatitis in Infancy and Early Childhood in a Nationwide Prescription Registry Study in Norway

et al. 2018

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Key Points Question Is the incidence rate of pediatric atopic dermatitis still increasing? Findings In this cohort study, all children resident in Norway younger than 6 years from January 1, 2009, through December 31, 2015, were included. The overall incidence rate of atopic dermatitis increased from 0.028 per person-year in 2009 to 0.034 per person-year in 2014, and for children younger than 1 year, the incidence rate increased from 0.052 per person-year in 2009 to 0.073 per person-year in 2014. Meaning This nationwide study suggests an increase in the incidence rate of pediatric atopic dermatitis, especially among children younger than 1 year.

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Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology

Cited by 87 publications

References 17 publications

Prevalência e fatores de risco para sibilância no primeiro ano de vida

Prevalência e fatores de risco para sibilância no primeiro ano de vida

Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze

Incidence Trends of Atopic Dermatitis in Infancy and Early Childhood in a Nationwide Prescription Registry Study in Norway

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