Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells

Abstract

Differential effects of quercetin and its two derivatives (isorhamnetin and isorhamnetin-3-glucuronide) in inhibiting proliferation of human breast cancer MCF-7 cells

Flavonoids as Anticancer Agents

“…Recent studies showed that quercetin reduced the proliferation of hepatocellular carcinoma HepG2 cells decreasing the intracellular ROS level [76]. It increased ROS production and the apoptotic cell number in human gastric cancer AGS [77] and human breast cancer MCF-7 cells [78]. Flavonol kaempferol inhibited the growth of cancerous bladder cells due to ROS level modulation-induced apoptosis and S phase arrest [79].…”

Microbial biocatalysis of quercetin-3-glucoside and isorhamnetin-3-glucoside inSalicornia herbaceaand their contribution to improved anti-inflammatory activity

“…1). 21 Research has shown that the specic makeup of each individual microbiome affects the range of catalysis occurring in each individual. 22 Hasegawa 23 reported that the pathways employed in in vivo conversion of glycosides may be different due to the diversity of microorganisms present in each host's gut.…”

Silica particles with a quercetin–R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus

“…9 Even if wellknown and characterized, thanks to its strong biological activity, quercetin is of continuously rising scientific interest. [10][11][12] For introducing a carboxylic acid linker into quercetin without affecting its function we chose to address the 7-hydroxy group. This was achieved by first completely acetylating quercetin with an excess of acetic anhydride in pyridine at 70 1C.…”