Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial

Chiva‐Blanch, Gemma; Urpí-Sardà, Mireia; Llorach, Rafaël; Rotches-Ribalta, María; Guillén, Marisa; Casas, Rosa; Arranz, Sara; Valderas-Martínez, Palmira; Portolés, Olga; Corella, Dolores; Tinahones, Francisco J.; Lamuela‐Raventós, Rosa M.; Andrés‐Lacueva, Cristina; Estruch, Ramón

doi:10.3945/ajcn.111.022889

Cited by 154 publications

(95 citation statements)

References 47 publications

(47 reference statements)

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“…Small randomised controlled clinical studies, however, as well as an observational study of 483 subjects followed for four years, suggest that moderate alcohol consumption reduces C-reactive protein, and the pro-inflammatory cytokines interleukin-6 and tissue necrosis factor-␣ [158,165,166]. Supporting the results of initial in vitro studies [167], a down-regulation and hence reduction in the plasma concentration of the soluble inflammatory mediators CD40 ligand, IL-16, monocyte chemotactic protein (MCP)-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin has also been recently observed in high-CVD-risk subjects following 30 g of alcohol/day [168].…”

Section: Inflammatory Effectssupporting

confidence: 54%

The relationships between alcohol, wine and cardiovascular diseases –A review

Stockley¹

2016

NUA

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Abstract.The relationship between alcohol consumption and the risk of cardiovascular disease has now been studied for over fifty years, and confirmed in multiples case-controlled and cohort studies, and subsequent meta-analyses of these studies. Sound experimental and clinical studies of plausible biological mechanisms support that there is a causal relationship between alcoholic beverages and cardiovascular disease. While beer, wine and spirits all contain alcohol, they are not necessarily equal in their effects on cardiovascular health, such as the incidence and mortality of coronary heart disease, stroke and all-cause mortality. Hence this review evaluates the available evidence, and details the biological mechanisms and attributes a percentage reduction in harm where possible.

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Section: Inflammatory Effectssupporting

confidence: 54%

The relationships between alcohol, wine and cardiovascular diseases –A review

Stockley¹

2016

NUA

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“…There is limited and conflicting evidence from interventional studies, typically with sample sizes of <100 participants and over relatively short periods of time, of the association between alcohol consumption and inflammation 7, 27, 28, 29. In terms of observational studies, some investigators have found that moderate alcohol consumption is associated with lower levels of CRP 30, 31, 32 and IL‐6 32, 33 compared to no alcohol and heavy alcohol intake, whereas others have observed no association 33, 34.…”

Section: Introductionmentioning

confidence: 99%

Ten‐year alcohol consumption typologies and trajectories of C‐reactive protein, interleukin‐6 and interleukin‐1 receptor antagonist over the following 12 years: a prospective cohort study

et al. 2016

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BackgroundModerate alcohol consumption is thought to confer cardiometabolic protective effects. Inflammatory pathways are hypothesized to partly underlie this association.ObjectivesThe aim of this study was to examine the association between typologies of alcohol consumption and markers of inflammation, and their rate of change over time.MethodsData were collected from 8209 participants [69% men; mean age, 50 years (SD 6.1)] of the British Whitehall II study. Alcohol consumption typologies were defined using up to three measures during an approximately 10‐year period spanning from 1985 to 1994 as (i) stable nondrinkers, (ii) stable moderate drinkers (referent), (iii) stable heavy drinkers, (iv) nonstable drinkers and (v) former drinkers. C‐reactive protein (CRP), interleukin (IL)‐6 and IL‐1 receptor antagonist (IL‐1 RA) were measured up to three times in the following 12 years.ResultsStable moderate drinkers had lower levels of CRP than stable nondrinkers, stable heavy drinkers, former drinkers and nonstable drinkers, but there were no differences in the rate of change in CRP over time between groups. Stable nondrinkers had higher levels of IL‐6 as did stable heavy drinkers; rates of change in IL‐6 over time were also increased in the latter group. Stable nondrinkers also had higher levels of IL‐1 RA. These associations were robust to adjustment for confounding factors.ConclusionOur novel investigation of 10‐year drinking typologies shows that stable moderate alcohol consumption is associated with a long‐term inflammatory marker profile that is consistent with conferring a reduced risk of developing coronary heart disease.

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“…On the other hand, only red wine reduced lipoprotein plasma concentrations (Chiva-Blanch et al, 2013a). In another study, the same authors showed that both ethanol and non-alcoholic components of red wine may regulate soluble inflammatory mediators in high-cardiovascular risk patients, whereas only phenolic compounds may modulate leukocyte adhesion molecules (Chiva-Blanch et al, 2012a). De-alcoholized red wine also decreased systolic and diastolic blood pressures in patients at high cardiovascular risk, and these variations correlated with increased concentration of plasma nitric oxide (NO) (a potent vasodilator) (Chiva-Blanch et al, 2012b).…”

Section: Variation Of Serum Biomarkersmentioning

confidence: 96%

“…Indeed, the balance between these two components seems to be greatly dependent on the specific type of beverage considered, as noticeable not only in view of wine over spirits or beer (Estruch et al, 2004(Estruch et al, , 2011Chiva-Blanch et al, 2012a, 2013b, but also by comparing white and red wine, the latter at higher content of polyphenols (Sacanella et al, 2007). Noteworthy, the comparison between red wine and dealcoholized red wine decreased blood pressure in patients at high cardiovascular risk (Chiva-Blanch et al, 2012b), excluding atrial fibrillation.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effects of moderate red wine consumption: Polyphenols vs. ethanol

Varoni¹

2014

JAB

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited.

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Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial

Cited by 154 publications

References 47 publications

The relationships between alcohol, wine and cardiovascular diseases –A review

The relationships between alcohol, wine and cardiovascular diseases –A review

Ten‐year alcohol consumption typologies and trajectories of C‐reactive protein, interleukin‐6 and interleukin‐1 receptor antagonist over the following 12 years: a prospective cohort study

Cardioprotective effects of moderate red wine consumption: Polyphenols vs. ethanol

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