Differential effects of olfactory bulbectomy on β-adrenoceptors in rat amygdala, hippocampus and cerebral cortex

Tiong, A. H. K.; Richardson, Jeremy

doi:10.1016/0006-8993(90)90783-8

Cited by 19 publications

(5 citation statements)

References 45 publications

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“…The results of this study are at variance with previous research which has found no signiÞcant di¤erences between sham and OB animals in b-adrenoceptor a¦nity in cortical tissue (Tiong and Richardson 1990); however, the results in that study showed a trend for a decrease in K d values for OB rats. In this study, Tiong and Richardson used ([) [ 125 ]iodocyanopindolol (ICYP) to determine b receptor binding, so the studies are not directly comparable.…”

Section: Discussioncontrasting

confidence: 80%

“…Numerous receptor changes have also been reported. b-Adrenoceptors are reportedly increased in the pons and hippocampus, reßecting a change in the binding a¦nity rather than binding density (Jesberger and Richardson 1986;Tiong and Richardson 1990), and the a¦nity of these receptors is increased in the amygdala and the hippocampus (Tiong and Richardson 1990). In addition, a 2 receptors are increased in the forebrain of OB rats (Hong et al 1987).…”

Section: Introductionmentioning

confidence: 95%

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The effect of venlafaxine treatment on the behavioural and neurochemical changes in the olfactory bulbectomised rat

McGrath

Norman

1998

Psychopharmacology

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In the present study, the effect of chronic treatment with venlafaxine on beta1 and 5-HT2 receptor populations was examined in the frontal cortex of olfactory bulbectomised (OB) and sham operated (SO) animals. The effect of these drugs on the behaviour of the animals on the elevated plus maze and the "open field" was also assessed. Removal of the bulbs resulted in a characteristic increase in locomotor activity in the OB animals in the "open field" which was reversed by chronic venlafaxine treatment. Venlafaxine produced a slight reduction in the number of open arm entries made by the OB animals although this failed to reach significance. Maximum change in temperature from baseline, following a single dose of 8-OH-DPAT (1.5 mg kg(-1) SC), was used to assess the function of the 5-HT1A receptors. Chronic venlafaxine treatment had no effect on the hypothermic response to 8-OH-DPAT in the present study. A decrease in the affinity of beta1-adrenoceptors was found following olfactory bulbectomy and this was normalised by treatment with venlafaxine. No bulbectomy-induced changes were evident 32 days post surgery in beta1-adrenoceptor density; however, chronic treatment with venlafaxine significantly reduced the density of these receptors in the OB animals. Olfactory bulbectomy did not produce any changes in 5-HT2 receptor populations but venlafaxine administration significantly reduced the density of these receptors in both SO and OB animals. The findings of the present study further validate the usefulness of the OB as an animal model, for the detection of antidepressants from a wide variety of classes.

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Section: Discussioncontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 95%

The effect of venlafaxine treatment on the behavioural and neurochemical changes in the olfactory bulbectomised rat

McGrath

Norman

1998

Psychopharmacology

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Section: Developmental Evidence: Functional Interdependencementioning

confidence: 99%

“…Efferents from the olfactory bulb reach the adult hippocampus (MacLean 1975) (in addition to the amygdala): for example, fast waves can be recorded in the dentate gyrus in response to olfactory stimuli (Heale 1994). Removal of the olfactory bulbs in rodents produces biochemical changes in the hippocampus (Tiong & Richardson 1990) and can impair learning in a radial maze task (Hall & Macrides 1983).Molecular evidence Transcription factors may be particularly informative, because they contribute to the developmental specification of a tissue. Expression of the WizL (widely-interspersed zinc finger) transcript is restricted to the olfactory bulb and the dentate gyrus (Matsumoto et al 1998), but this could reflect the presence of dividing cells therein (see below).…”

mentioning

confidence: 99%

Hormones and the hippocampus

Lathe

2001

Journal of Endocrinology

222

161

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Hippocampal lesions produce memory deficits, but the exact function of the hippocampus remains obscure. Evidence is presented that its role in memory may be ancillary to physiological regulation. Molecular studies demonstrate that the hippocampus is a primary target for ligands that reflect body physiology, including ion balance and blood pressure, immunity, pain, reproductive status, satiety and stress. Hippocampal receptors are functional, probably accessible to their ligands, and mediate physiological and cognitive changes. This argues that an early role of the hippocampus may have been in sensing soluble molecules (termed here 'enteroception') in blood and cerebrospinal fluid, perhaps reflecting a common evolutionary origin with the olfactory system ('exteroception').Functionally, hippocampal enteroception may reflect feedback control; evidence is reviewed that the hippocampus modulates body physiology, including the activity of the hypothalamus-pituitary-adrenal axis, blood pressure, immunity, and reproductive function. It is suggested that the hippocampus operates, in parallel with the amygdala, to modulate body physiology in response to cognitive stimuli. Hippocampal outputs are predominantly inhibitory on downstream neuroendocrine activity; increased synaptic efficacy in the hippocampus (e.g. long-term potentiation) could facilitate throughput inhibition. This may have implications for the role of the hippocampus and long-term potentiation in memory. Journal of Endocrinology (2001) 169, 205-231The hippocampus and memory Attention has focused on the hippocampus in view of its likely role in memory encoding and its dysfunction in Alzheimer's disease. The hippocampal formation undoubtedly contributes to the encoding of long-term memories, but an exclusive focus on memory would be a mistake. The present review emphasises an important aspect of hippocampal function: that of responding to and governing body physiology. What follows briefly revisits the role of the hippocampus in learning and memory, and the electrophysiological correlates of memory processes, before considering how the spectrum of genes expressed in the hippocampal formation may cast light on the involvement of the hippocampus in other processes. (In this paper, 'hippocampus' and 'hippocampal formation' are used interchangably to denote the juxtaposition of the fields of the cornu ammonis with the dentate gyrus.) Memory and the hippocampusThe hippocampus, located beneath the cerebral hemispheres, resembles a large 'wishbone' (the curved Y-shaped bone in the chicken neck), but takes its name from the appearance of its arms in cross-section -the interlocking double-U formed by the tightly aligned cell bodies of ammon's horn (cornu ammonis) and the dentate gyrus -reminiscent of the shape of Hippocampus spp. ( Fig. 1; for detailed reviews of hippocampal structure see Amaral 1987, Amaral & Witter 1989. Memory problems in a patient with limbic damage (i.e. at the edge of the forebrain) were first recorded in 1898; another 60 years elapsed be...

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“…Many of these effects are not observed in animals rendered anosmic by destroying the olfactory receptor cells through irrigation of the nasal mucosa with zinc sulfate (ZnSO 4 ) (Alberts and Friedman 1972;Edwards 1974;Sieck and Baumbach 1974). Consequently, the OBX syndrome is believed to result from dysfunction in brainstem and limbic areas involving a variety of neurochemical and neuropharmacological changes affecting many different transmitter systems (Pohorecky et al 1969;Hirsh 1980;Janscar and Leonard 1984;Tiong and Richardson 1990;Gurevich et al 1993). Numerous studies have also demonstrated that many of the behavioral and biochemical alterations invoked by OBX are reversed by chronic administration of most antidepressant drugs (Van Riezen et al 1976;Cairncross et al 1978Cairncross et al , 1979aJesberger and Richardson 1986;Kelly et al 1997).…”

Section: Introductionmentioning

confidence: 97%

Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

2000

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Differential effects of olfactory bulbectomy on β-adrenoceptors in rat amygdala, hippocampus and cerebral cortex

Cited by 19 publications

References 45 publications

The effect of venlafaxine treatment on the behavioural and neurochemical changes in the olfactory bulbectomised rat

The effect of venlafaxine treatment on the behavioural and neurochemical changes in the olfactory bulbectomised rat

Hormones and the hippocampus

Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

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