Differential effects of nonylphenol on testosterone secretion in rat Leydig cells

Wu, Jen-Jung; Wang, Kai-Lee; Wang, Shyi-Wu; Hwang, Guey-Shyang; Mao, I‐Fang; Chen, Mei-Lien; Wang, Paulus S.

doi:10.1016/j.tox.2009.10.030

Cited by 58 publications

(35 citation statements)

References 37 publications

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“…These suggest that the chemical exposures may induce severe abnormalities in reproductive development. This hypothesis may be supported by a previous study (Wu et al, 2010), which indicated that NP had differential effects on testosterone synthesis.…”

Section: Discussionsupporting

confidence: 70%

Toxic effect of gestational exposure to nonylphenol on F1 male rats

Wang

et al. 2010

Birth Defects Research Pt B

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Section: Discussionsupporting

confidence: 70%

Toxic effect of gestational exposure to nonylphenol on F1 male rats

Wang

et al. 2010

Birth Defects Research Pt B

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“…The effects could partly be explained by inhibition of CYP17 enzyme activity as well as inhibition of CYP11A1 and CYP21A2 activities. Nonylphenol is also reported to decrease serum testosterone levels in adult rats (34,35). In a threegeneration feeding study in rats given 25,200, and 750 ppm 4-nonylphenol in the diet, testosterone levels were reduced at postnatal Day 2 at all dose levels in the F1 generation, but not in the F2 or F3 generations (36).…”

Section: Discussionmentioning

confidence: 95%

Suppressed Sex Hormone Biosynthesis by Alkylresorcinols: A Possible Link to Chemoprevention

Oskarsson

Andersson

2016

Nutrition and Cancer

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Alkylresorcinols (ARs, 5-n-alkylresorcinols) are amphiphilic phenolic lipids in whole grain rye and wheat, with a long odd-numbered carbon chain. A preventive effect of whole grain diet on sex hormone-dependent cancers has been recognized, but the active component(s) or mechanisms are not known. We have investigated the effects of the ARs C15:0, C19:0, and C21:0, individually and in combination, on steroid hormone production by using the human adrenocortical cell line H295R. Decreased synthesis of dehydroepiandrosterone (DHEA), testosterone, and estradiol was demonstrated at low concentrations of C15:0 and C19:0. There were no indications of additive effects on steroid secretion from the combined treatment with equimolar concentrations of the three ARs. Gene expressions of CYP21A2, HSD3B2, and CYP19A1 were downregulated and CYP11A1 was upregulated by the ARs. The results on gene expression could not explain the effects on steroidogenesis, which may be due to direct effects on enzyme activities, such as inhibition of CYP17A1. Our results demonstrate suppressed synthesis of testosterone and estradiol by ARs suggesting a novel mechanism for ARs in the chemoprevention of prostate and breast cancer.

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“…Sayed Ael et al (2012) found that NP-treated Clarias gariepinus were associated with the decrease of FSH, LH and testosterone concentrations but the17-beta-estradiol level was increased [42]. Wu et al (2010) indicated that NP has differential effects on testosterone synthesis: stimulated testosterone release through increase of both protein levels and activities of steroidogenic acute regulatory (StAR) protein and of cytochrome P450 side-chain cleavage (P450scc) protein, and in contrast, inhibited human chorionic gonadotropin-induced testosterone release in rat Leydig cells [43].…”

Section: Discussionmentioning

confidence: 99%

The Association between Nonylphenols and Sexual Hormones Levels among Pregnant Women: A Cohort Study in Taiwan

et al. 2014

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BackgroundNonylphenol (NP) has been proven as an endocrine disrupter and had the ability to interfere with the endocrine system. Though the health effects of NP on pregnant women and their fetuses are sustained, these negative associations related to the mechanisms of regulation for estrogen during pregnancy need to be further clarified. The objective of this study is to explore the association between maternal NP and hormonal levels, such as estradiol, testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH), and progesterone.MethodsA pregnant women cohort was established in North Taiwan between March and December 2010. Maternal urine and blood samples from the first, second, and third trimesters of gestation were collected. Urinary NP concentration was measured by high-performance liquid chromatography coupled with fluorescent detection. A mixed-effects model using a generalised estimating equation (GEE) was applied to assess the associations between maternal NP concentration and plasma hormones throughout the three trimesters.ResultsIn total, 162 singleton pregnant women completed this study through delivery. The geometric mean of creatinine-adjusted urinary NP concentrations were 4.27, 4.21, and 4.10 µg/g cre. in the first, second, and third trimesters respectively. A natural log-transformation of urinary NP concentrations were significantly associated with LH in the GEE model (β = −0.23 mIU/ml, p<0.01).ConclusionThis perspective cohort study demonstrates that negative association occurs between maternal NP exposure and plasma LH levels. The estrogen-mimic effect of NP might influence the negative feedback on LH during pregnancy.

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Differential effects of nonylphenol on testosterone secretion in rat Leydig cells

Cited by 58 publications

References 37 publications

Toxic effect of gestational exposure to nonylphenol on F1 male rats

Toxic effect of gestational exposure to nonylphenol on F1 male rats

Suppressed Sex Hormone Biosynthesis by Alkylresorcinols: A Possible Link to Chemoprevention

The Association between Nonylphenols and Sexual Hormones Levels among Pregnant Women: A Cohort Study in Taiwan

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