1998
DOI: 10.1111/j.1398-9995.1998.tb03867.x
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Differential effects of new‐generation H1‐receptor antagonists in pruritic dermatoses

Abstract: In search of an improved treatment of pruritic dermatoses, we have studied azelastine, a novel H1-receptor antagonist, during a 2-week treatment period, using a double-blind, placebo-controlled design. The potent H1-antagonist cetirizine was used for comparison. Symptoms were recorded daily by the patients on a diary card, using a 4-point scale. The same parameters and adverse events were evaluated at weekly intervals, and global improvement was evaluated at the end of treatment. In all 230 evaluable patients … Show more

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Cited by 41 publications
(22 citation statements)
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“…Antihistamines (AH) have been used for decades, in an attempt to relieve pruritus in patients with AE. However, only a few randomized controlled trials have been conducted and they have in the majority shown only a weak or no effect in decreasing pruritus . According to a Cochrane search, randomized controlled trials investigating the efficacy of AH monotherapy in eczema patients are lacking …”
Section: Antipruritic Therapymentioning
confidence: 99%
“…Antihistamines (AH) have been used for decades, in an attempt to relieve pruritus in patients with AE. However, only a few randomized controlled trials have been conducted and they have in the majority shown only a weak or no effect in decreasing pruritus . According to a Cochrane search, randomized controlled trials investigating the efficacy of AH monotherapy in eczema patients are lacking …”
Section: Antipruritic Therapymentioning
confidence: 99%
“…While histamine is the crucial mediator in urticaria, and H1 receptor blockers may abolish itch in this condition, 29 its role in AD is unclear. While histamine is the crucial mediator in urticaria, and H1 receptor blockers may abolish itch in this condition, 29 its role in AD is unclear.…”
Section: Discussionmentioning
confidence: 99%
“…However, the documentation of this side effect is based mainly on patients’ subjective reports rather than on clinical examination [5, 8, 9]. Considering the scarce information about the adverse effects of new generation antihistamines on salivation, this pilot study aimed to examine the effect of loratadine and fexofenadine on salivary gland function in patients diagnosed with allergic rhinitis.…”
Section: Discussionmentioning
confidence: 99%