1994
DOI: 10.1007/bf01051044
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Differential effects of methionine enkephalin on the growth of brain tumor cells

Abstract: The effect of methionine enkephalin on the growth of human brain tumor cells was investigated. The results show that this endogenous opioid has dual effects on tumor cell growth. This peptide exerted an inhibitory effect in SK-N-MC human neuroblastoma cell line; in contrast, in U-373 MG human astrocytoma cell line, the peptide showed a stimulatory effect. Treatment with naltrexone, an opioid receptor antagonist, also resulted in a similar alteration of tumor cell growth implicating that its action may be unrel… Show more

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Cited by 16 publications
(8 citation statements)
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“…1998). The ability to stimulate either traditional opioid signalling pathways (see Huang 1995) and/or MAP‐kinase may explain how opioids can have varied effects on cell division (Lee & Wurster 1994; Law & Bergsbaken 1995; Hauser & Mangoura 1998; Knapp et al . 1998).…”
Section: Discussionmentioning
confidence: 99%
“…1998). The ability to stimulate either traditional opioid signalling pathways (see Huang 1995) and/or MAP‐kinase may explain how opioids can have varied effects on cell division (Lee & Wurster 1994; Law & Bergsbaken 1995; Hauser & Mangoura 1998; Knapp et al . 1998).…”
Section: Discussionmentioning
confidence: 99%
“…Met 5 enkephalin has dual effects on tumor cell growth. This peptide exerted an inhibitory effect in SK-N-MC human neuroblastoma cell line; in contrast, it stimulates the growth of U-373 MG human astrocytoma cell line (103). Beta casomorphine-5, and DAMGO stimulated neurite outgrowth, while DPDPE and U-50488, a kappa agonist, had no effect (104).…”
Section: Opioids and Somatostatin In Cancer Cell Proliferationmentioning
confidence: 94%
“…RHAMM isoforms are involved in regulation of extracellular signal-regulated kinase (ERK) activity (Zhang et al, 1998), a protein kinase activated in response to a variety of growth factors. The expression of preproenkephalin is higher in dividing cells than in confluent cells (Hildebrand et al, 1997) and Met-enkephalin stimulated the growth of astrocytoma cells (Lee and Wurster, 1994). S-100 42A has been shown to control cell cycle progression via sequestration and inactivation of p53 (reviewed in a Relative P bins were converted to absolute P-false values as described .…”
Section: Discussionmentioning
confidence: 99%