Differential effects of MDMA and scopolamine on working versus reference memory in the radial arm maze task

Kay, Christian; Harper, David N.; Hunt, Maree

doi:10.1016/j.nlm.2009.09.005

Cited by 47 publications

(78 citation statements)

References 27 publications

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“…The conclusions of the above studies were that acute MDMA results in working memory impairments. However, it has been argued that these findings do not involve working memory effects, but rather reflect disruptions of reference memory involving the rules or strategies associated with a given task (Harper et al, 2005; 2006; Kay et al, 2010). As an illustration, Kay et al (2010) used a version of the radial arm maze designed to separate working and reference memory and found that MDMA had no effect on the working memory task (arms were always baited for one visit), but impaired the reference memory task (arms that were never baited throughout the experiment).…”

Section: Discussionmentioning

confidence: 99%

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

et al. 2014

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Acute effects of methylenedioxymethamphetamine (MDMA), methamphetamine (MA) and methylphenidate (MPD) were studied using a within-subject, repeated acquisition/performance procedure adapted to the Morris Swim Task. To investigate place learning, the acquisition component consisted of a hidden platform that varied in location across experimental sessions. As a control for drug effects not specific to acquisition, a performance component was included in which the hidden platform was in the same pool location in every experimental session. All three drugs increased escape latencies and swim distances in dose-dependent fashion. However, impairment in the acquisition component was generally observed only at doses that also produced impairment in the performance component, suggesting that effects were not selective to place learning. None of the drugs produced enhancement of learning or performance at any dose. Taken together, the results suggest that acute exposure to these psychomotor stimulants produce global impairment of performance in the Morris task, rather than specific deficits in place learning.

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Section: Discussionmentioning

confidence: 99%

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

et al. 2014

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“…Both scopolamine and mecamylamine were found to impair working memory functions of rats and monkeys in maze tasks (Beatty and Bierley 1985;Kay et al 2010;Kobayashi et al 1995;Levin et al 1987;Ohno et al 1993;Okaichi et al 1989;Tatsumi et al 2006;Wirsching et al 1984) and delayed matching tasks (e.g. Granon et al 1995;Spinelli et al 2006).…”

Section: Working Memory-studies In Animalsmentioning

confidence: 98%

“…Cholinergic influence on working memory in humans and animalsBeatty and Bierley 1985;Kay et al 2010;Okaichi et al 1989;Tatsumi et al 2006;Wirsching et al 1984 …”

mentioning

confidence: 99%

Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: An overview of preclinical and clinical findings

et al. 2011

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“…Two interesting possibilities include direct and indirect activation of postsynaptic 5-HT 2A and 5-HT 1A receptors, respectively. It is clear from animal studies that 5-HT 2A receptors mediate learning and memory processes (Galizio et al, 2009;Kay et al, 2010;Trigo et al, 2008); however, it is not completely obvious whether 5-HT 2A receptor drugs achieve their facilitating and impairing effects through agonism, antagonism or inverse agonism (Meneses, 2002). Still, there seems to be some consensus that a 5-HT 2A blockade not only improves learning, but reverses poor memory consolidation conditions associated with, among others, dysfunctional serotonergic neurotransmission (Meneses, 2007a, b) as well.…”

Section: Introductionmentioning

confidence: 99%

Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

Wel

Kuypers

Theunissen

et al. 2011

Neuropsychopharmacol

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3,4-Methylenedioxymethamphetamine (MDMA) or 'ecstasy' has been associated with memory deficits during abstinence and intoxication. The human neuropharmacology of MDMA-induced memory impairment is unknown. This study investigated the role of 5-HT 2A and 5-HT 1A receptors in MDMA-induced memory impairment. Ketanserin is a 5-HT 2A receptor blocker and pindolol a 5-HT 1A receptor blocker. It was hypothesized that pretreatment with ketanserin and pindolol would protect against MDMA-induced memory impairment. Subjects (N ¼ 17) participated in a double-blind, placebo-controlled, within-subject design involving six experimental conditions consisting of pretreatment (T1) and treatment (T2). T1 preceded T2 by 30 min. T1-T2 combinations were: placebo-placebo, pindolol 20 mg-placebo, ketanserin 50 mg-placebo, placebo-MDMA 75 mg, pindolol 20 mg-MDMA 75 mg, and ketanserin 50 mg-MDMA 75 mg. Memory function was assessed at Tmax of MDMA by means of a word-learning task (WLT), a spatial memory task and a prospective memory task. MDMA significantly impaired performance in all memory tasks. Pretreatment with a 5-HT 2A receptor blocker selectively interacted with subsequent MDMA treatment and prevented MDMA-induced impairment in the WLT, but not in the spatial and prospective memory task. Pretreatment with a 5-HT 1A blocker did not affect MDMA-induced memory impairment in any of the tasks. Together, the results demonstrate that MDMA-induced impairment of verbal memory as measured in the WLT is mediated by 5-HT 2A receptor stimulation.

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Differential effects of MDMA and scopolamine on working versus reference memory in the radial arm maze task

Cited by 47 publications

References 27 publications

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: An overview of preclinical and clinical findings

Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

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