1983
DOI: 10.1530/jrf.0.0690569
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Differential effects of LH-RH immunoneutralization on LH and FSH secretion in the ewe

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Cited by 26 publications
(10 citation statements)
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References 29 publications
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“…Thus, the basal secre tion of FSH persisted for 2 weeks in the presumed absence of pulsatile GnRH release. A differential regulation of LH and FSH secretion, like that shown here, has been observed in other situations and species [10,14,18,23,48]. In a directly analogous study, Clarke et al [10] observed con tinuing FSH secretion for up to I week in ewes after pulsa tile GnRH and LH secretion were abolished by surgical dis connection of the pituitary from the hypothalamus.…”
Section: Discussionsupporting
confidence: 81%
“…Thus, the basal secre tion of FSH persisted for 2 weeks in the presumed absence of pulsatile GnRH release. A differential regulation of LH and FSH secretion, like that shown here, has been observed in other situations and species [10,14,18,23,48]. In a directly analogous study, Clarke et al [10] observed con tinuing FSH secretion for up to I week in ewes after pulsa tile GnRH and LH secretion were abolished by surgical dis connection of the pituitary from the hypothalamus.…”
Section: Discussionsupporting
confidence: 81%
“…This slow and incomplete effect was reflected in the lack of responsiveness to the pulses of analogue. These observations are consistent with those of Lincoln and Short (1980) (Clarke et al, 1978), and passive immunization against LH-RH in entire ewes during the follicular phase leads to an increase in the levels of FSH, probably through deprivation of oestrogen (Fraser and McNeilly, 1983). Normally, FSH levels fall during the follicular phase due to the build-up in oestrogen levels (Baird and McNeilly, 19811.…”
Section: Introductionsupporting
confidence: 77%
“…2) supports a previous hypothesis (Goodman et ai, 1982) that during seasonal anoestrus oestradiol can suppress LH pulse frequency with a corresponding increase in LH pulse amplitude. The conclusion that oestradiol acts on the LHRH pulse generating system is further supported by reports that a pulse of LH is preceded or accompanied by a pulse of LHRH from the hypothalamus (Clarke & Cummins, 1982 ; Levine, Pan, Ramirez & Jackson, 1982 (Fraser & McNeilly, 1983).…”
Section: Peripheral Plasma Fsh Concentrationsmentioning
confidence: 78%