Differential effects of isoflavones on bone formation in growing male and female mice

Soybean isoflavone exposure does not have feminizing effects on men: a critical examination of the clinical evidence

“…For this reason, in response to the consumption of soy foods and mixed isoflavones as found in soybeans or daidzein, circulating equol levels in rats and monkeys (126) far exceed those of daidzein and genistein (44,127). Chemically, equol and daidzein are different molecules, and they often exert different physiologic effects (33).…”

Nutrition for Enhancing Bone Volume in Mice

“…In addition, isoflavone was revealed to affect bone metabolism similarly to the sex hormone-like effect in male (Chavarro et al, 2008). Recently, it was also reported that isoflavones have revealed inhibition of bone loss in castrated male mice and growing male mice respectively (Fujioka et al, 2007;Ishimi et al, 2002;Khalil et al, 2005). Under such background, a new snack was developed by use of black soybean.…”

Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats

“…21d immature female Sprague-Dawley rats were used for the study [13]. All rats were housed at 21°C, in 12-h light:12-h dark cycles.…”

“…In adult Ovx mice on high calcium diet, daidzein at 100 mg kg −1 day −1 oral dose for 12 weeks favorably influenced both trabecular and cortical bone [12]. An intriguing report shows that daidzein fed immature mice exhibited sexually dimorphic skeletal effect with increased BMD and bone formation in males and decreased in females when compared with controls [13]. From these reports, it appears that daidzein could favorably affect PBM achievement, likely via its metabolite, equol [14].…”