Differential effects of intraspecific interactions on the striatal dopamine system in social and non-social voles

Curtis, J. Thomas; Stowe, Jennifer R.; Wang, Z

doi:10.1016/s0306-4522(03)00032-0

Cited by 28 publications

(19 citation statements)

References 40 publications

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“…The dialysis membrane had a 1.0-mm active area and molecular weight cutoff of 18 kDa. Probes were perfused continuously at 1.0 L/min with an isotonic solution using a glass Hamilton syringe connected to an automatic micropump (World Precision Instruments) (52). Dialysates were collected every 5 min, for five consecutive samples before RIT (baseline), and then for 1 h during RIT into vials containing 5 L 0.1 N HCl, immediately frozen on dry ice, and stored at Ϫ80°C.…”

Section: Methodsmentioning

confidence: 99%

“…Experiment 1 used brain microdialysis with AVP ELISA analysis to measure AVP release in the AH during selective aggression. Males that were pair-bonded for 2 weeks were stereotaxically implanted with a microdialysis probe aimed at the AH, while the probe was infused continuously with an isotonic solution (52). After overnight recovery, baseline samples were collected before behavioral testing.…”

Section: Methodsmentioning

confidence: 99%

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Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Gobrogge

Liu

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

155

177

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After pair-bonding, male prairie voles (Microtus ochrogaster) display aggression toward novel females but not toward their female partner. Here we show that this selective aggression in pair-bonded male prairie voles is associated with increased release of vasopressin (AVP) in the anterior hypothalamus (AH). Pharmacological activation of AVP-V1a receptors (V1aR) in the AH induced selective aggression in sexually naive males, whereas V1aR blockade diminished selective aggression in pair-bonded males. Pair-bonded males also showed an increased density in V1aR binding in the AH compared to their sexually naive counterparts and overexpression of V1aR in the AH, by viral vector-mediated gene transfer, facilitated aggression toward novel females. These data demonstrate that AH-AVP is both necessary and sufficient in the regulation of selective aggression associated with pair-bonding. In the second part of this study, we examined the effects of amphetamine (AMPH) exposure on female-directed aggression and revealed the potential role of AH-AVP underlying this behavior. Repeated AMPH administration in sexually naive male prairie voles enhanced V1aR expression in the AH and induced aggression toward a familiar or unfamiliar female. In addition, this AMPH-induced aggression was blocked by intra-AH administration of a V1aR antagonist. Together, our data reveal a socioneurobiological mechanism, highlighting a critical role of AH-AVP in the regulation of aggression induced by pair-bonding or drug experience in socially monogamous male prairie voles.behavioral pharmacology ͉ drug abuse ͉ microdialysis ͉ neural plasticity ͉ viral-vector gene transfer A ggression is an agonistic behavior that plays an important role for survival and reproductive success. In both vertebrates (1) and invertebrates (2), aggression promotes fitness by acquiring territory, food, and mates, as well as by serving to protect offspring and avoid predation. In humans and nonhuman primates, aggressive behavior operates within social hierarchies to facilitate resource acquisition (3). Among the neurochemicals implicated in aggression (4, 5), arginine vasopressin (AVP), and its homolog vasotocin, have been found to regulate several forms of aggression in numerous species (6, 7) across diverse taxa (8, 9). Even in humans, central AVP correlates with aggressive behavior (10) and mediates anger (11). Therefore, the AVP system may have evolved to be primed by a wide variety of experiences to induce aggression, when appropriate, in social animals (12).Drug use can override neurobiological programs to activate maladaptive forms of agonistic behavior, engaging inappropriate types of physical aggression (13), such as domestic violence (14) and intimate partner homicide (15). As a result, chronic drug abuse can cause permanent neural reorganization (16,17), impairing the adaptive social brain (18), leading to the display of maladaptive social behavior (19). In rodent models such as hamsters, adolescent exposure to cocaine (20) or anabolic steroids (21, 22) induces ag...

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Gobrogge

Liu

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

155

177

View full text Add to dashboard Cite

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“…DA, particularly in mesolimbic brain regions, has also been implicated in the mediation of a variety of natural rewards (Wise et al, 1989;Bozarth, 1991) including mating (Everitt, 1990) which facilitates pair bonding (Carter et al, 1990;Williams et al, 1992b;Insel et al, 1995b;Curtis et al, 2003a;Wang et al, 2004). For these reasons, DA was hypothesized to play a role in pair bonding and the DAergic regulation of social attachment has since become an important focus of the field.…”

Section: Dopaminergic Regulation Of Social Attachment Indeedmentioning

confidence: 99%

“…Mating facilitates pair bonding (Carter et al, 1990;Williams et al, 1992b;Insel et al, 1995b;Wang et al, 2004) and increases DA activity in the NAcc of both male and female prairie voles (Gingrich et al, 2000;Aragona et al, 2003;Curtis et al, 2003a). It has therefore been suggested that DA plays an important role in pair bonding behavior.…”

Section: Dopaminergic Regulation Of Social Attachment Indeedmentioning

confidence: 99%

The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies

Young

Liu

Wang

2008

Comparative Biochemistry and Physiology Part C: Toxicology &

130

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The formation and maintenance of social bonds in adulthood is an essential component of human health. However studies investigating the underlying neurobiology of such behaviors have been scarce. Microtine rodents offer a unique comparative animal model to explore the neural processes responsible for pair bonding and its associated behaviors. Studies using monogamous prairie voles and other related species have recently offered insight into the neuroanatomical, neurobiological, and neurochemical underpinnings of social attachment. In this review, we will discuss the utility of the microtine rodents in comparative studies by exploring their natural history and social behavior in the laboratory. We will then summarize the data implicating vasopressin, oxytocin, and dopamine in the regulation of pair bonding. Finally, we will discuss the ways in which these neurochemical systems may interact to mediate this complex behavior.

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“…Studies comparing monogamous and non-monogamous species of voles have identified differences in the functioning of dopamine systems [9] and in other neurotransmitter systems that interact with dopamine in the regulation of pair bonding [30,31,46,51]. To date most research into dopamine's role in pair bonding has focused on mesolimbic dopamine ''reward'' pathways, and in particular, on the ventral striatum/nucleus accumbens (NAcc).…”

Section: Introductionmentioning

confidence: 99%

Ventral tegmental area involvement in pair bonding in male prairie voles

Curtis

Wang

2005

Physiology & Behavior

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Dopamine is known to play a critical role in social attachment in monogamous voles. However, little is known about the neurochemical regulation of central dopamine release during pair bond formation. Here we examine the effects on partner preference formation in male prairie voles of neurochemical manipulations in the ventral tegmental area (VTA), a major source of dopamine to brain regions implicated in pair bonding. Administration of NBQX, an AMPA receptor antagonist, or bicuculline, a GABA receptor antagonist, into the VTA induced partner preferences within 6 h in the absence of mating. We also found that, after unilateral administration of NBQX into the VTA, neuronal activation, as indicated by the expression of the immediate early gene c-fos, was decreased in the nucleus accumbens, prefrontal cortex, and medial amygdala, but was unchanged in the lateral septum and in a control region, the arcuate nucleus. These results confirm a role for the VTA in partner preference formation in monogamous voles and extend the list of neurochemicals important in pair bonding to include glutamate and GABA. D

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Differential effects of intraspecific interactions on the striatal dopamine system in social and non-social voles

Cited by 28 publications

References 40 publications

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies

Ventral tegmental area involvement in pair bonding in male prairie voles

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