Differential Effects of Fetal Number and Maternal Nutrition in Late Gestation on Prolactin Receptor Abundance and Adipose Tissue Development in the Neonatal Lamb

Budge, Helen; Dandrea, J; Mostyn, A; Evens, Yvonne; Watkins, Ryan; Sullivan, Claire; Ingleton, P. M.; Stephenson, Terence; Symonds, Michael

doi:10.1203/00006450-200302000-00016

Cited by 34 publications

(11 citation statements)

References 41 publications

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“…In contrast to many other fetal organs, the growth of adipose tissue is subject to marked nutritional constraints. 25 As shown in Table 3, serum leptin concentration was associated only with adiponectin at PMA 33 weeks. Thus, WAT volume may not increase strictly as a function of BW, especially from PMA 33 weeks to PMA 38 weeks.…”

Section: Discussionmentioning

confidence: 89%

Extrauterine growth and adipocytokines in appropriate‐for‐gestational‐age preterm infants

Nagasaki

Ohta

2016

Pediatrics International

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Section: Discussionmentioning

confidence: 89%

Extrauterine growth and adipocytokines in appropriate‐for‐gestational‐age preterm infants

Nagasaki

Ohta

2016

Pediatrics International

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“…Plasma concentration of non-esterified fatty acids (NEFA) was measured enzymatically (Clarke et al 1994) and plasma PRL was measured by RIA (McMillen et al 1987, Budge et al 2003. Briefly, all samples were assayed in duplicate following a 1:10 and 1:50 dilution using a rabbit anti-ovine prolactin primary antibody, iodinated ovine prolactin and goat anti-rabbit secondary antibody.…”

Section: Metabolite and Hormone Analysismentioning

confidence: 99%

Prolactin, the prolactin receptor and uncoupling protein abundance and function in adipose tissue during development in young sheep

Pearce¹,

Budge²,

Mostyn³

et al. 2005

Journal of Endocrinology

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A primary role of the prolactin receptor (PRLR) during fetal and postnatal development has been suggested to be the regulation of uncoupling protein (UCP) expression. We, therefore, determined whether: (1) the rate of loss of UCP1 from brown adipose tissue after birth was paralleled by the disappearance of PRLR; and (2) administration of either pituitary extract prolactin (PRL) containing a mixture of posttranslationally modified forms or its pseudophosphorylated form (S179D PRL) improved thermoregulation and UCP1 function over the first week of neonatal life. PRLR abundance was greatest in adipose tissue 6 h after birth before declining up to 30 days of age, a trend mirrored by first a gain and then a loss of UCP1. In contrast, in the liver -which does not possess UCPsa postnatal decline in PRLR was not observed. Administration of PRL resulted in an acute increase in colonic temperature in conjunction with increased plasma concentrations of non-esterified fatty acids and, as a result, the normal postnatal decline in body temperature was delayed. S179D PRL at lower concentrations resulted in a transient rise in colonic temperature at both 2 and 6 days of age. In conclusion, we have demonstrated a close relationship between the ontogeny of UCP1 and the PRLR. Exogenous PRL administration elicits a thermogenic effect suggesting an important role for the PRLR in regulating UCP1 function.

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“…Foetal adipose tissue development is known to be very sensitive to foetal nutrition in late gestation (Shrestha and Heaney, 1990;Budge et al, 2003). Triplet lambs have experienced some degree of under nutrition in utero (Kaulfuss et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

Neonatal lamb behaviour and thermoregulation with special reference to thyroid hormones and phosphorous element: Effect of birth weight and litter size

Darwish

El-Bahr

2008

Journal of Veterinary Medical Research

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New-born lambs have limited energy reserves and need a rapid access to colostrum to maintain homeothermy and survive. The object of this study was to investigate the importance of neonatal lamb behaviour in the maintenance of its body temperature and survival. The time taken to stand and suck after birth and rectal temperatures were determined in 72 crossbred lambs (progeny of crossing 1/2 Rhamani and 1/2 Finnish). In addition, blood samples were collected at 1, 24 and 72 h after birth. The obtained sera were assayed for thyroid hormones (T 3 and T 4 ), known to be involved in heat production and phosphorous element (ph) which is essential for energy metabolism. The obtained results revealed that, low birth weight and triplet lambs were behaviourally less active at birth and had less T 3 , T 4 , Ph and body temperatures values over the first 3 days of life than lambs of heavy or medium birth weight and single or twin lambs. Thus, light weight and triplet lambs were highly susceptible to hypothermia and were exposed to high rate of mortality (18.75 and 16.66%) during the neonatal period than other lambs (3.84, 10.00, 4.55, and 9.38 %, respectively). Therefore, the present study concludes that neonatal lamb behaviour, specifically success in standing and obtaining colostrum are extremely important for thermoregulation and survival of the neonate.

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Differential Effects of Fetal Number and Maternal Nutrition in Late Gestation on Prolactin Receptor Abundance and Adipose Tissue Development in the Neonatal Lamb

Cited by 34 publications

References 41 publications

Extrauterine growth and adipocytokines in appropriate‐for‐gestational‐age preterm infants

Extrauterine growth and adipocytokines in appropriate‐for‐gestational‐age preterm infants

Prolactin, the prolactin receptor and uncoupling protein abundance and function in adipose tissue during development in young sheep

Neonatal lamb behaviour and thermoregulation with special reference to thyroid hormones and phosphorous element: Effect of birth weight and litter size

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