Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells

Abstract

Different effects of MSC-EVs on cancer cells were observed depending on their tissue of origin. Moreover, MSC-EVs can deliver antiblastic drugs to glioblastoma cells.

Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma

“…In addition, several studies have reported that MSCs have no apparent effect on N32 tumor cell growth (Komarova et al, 2006;Kucerova et al, 2007;Bexell et al, 2009). Another study using extracellular vesicles from different sources has revealed that the different effects of BM-, UC-, and AT-MSCs on U87 tumor cell growth may depend on the tissue of origin (del Fattore et al, 2015). This finding demonstrates the complexity of MSCs.…”

Extracellular vesicles as regulators of tumor fate: crosstalk among cancer stem cells, tumor cells and mesenchymal stem cells

“…This divergence could in part be attributed to different experimental models: in vitro/in vivo models, MSC origins, protocols for EVs isolation, and the amount and period of EV administration. In an attempt to understand the possible influence of MSC sources, Del Fattore et al (110) studied the effects of EVs derived from bone marrow, umbilical cord and adipose tissue MSCs on glioblastoma cells. They found that EVs derived from bone marrow and umbilical cord inhibited tumor cell proliferation and induced apoptosis, while those derived from adipose tissue stimulated tumor proliferation, confirming the relevance of the cell source.…”

Extracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myeloma

“…EVs from MSCs co-injected with tumor cells seem to promote tumor growth, whereas they suppress tumor progression when they were administered after the tumor had been established [43]. Additionally, the source of the obtained MSCs seems to be of capital importance as shown by Del Fattore et al ., who demonstrated that EVs from MSCs derived from either BM or the umbilical cord decreased proliferation and induced apoptosis of glioblastoma cells in vitro , while EVs from MSCs isolated from adipose tissue had opposite effects [44]. …”