Differential effects of exogenous and endogenous estrogen on anxiety as measured by elevated T-maze in relation to the serotonergic system

Pandaranandaka, Jantarima; Poonyachoti, Sutthasinee; Kalandakanond-Thongsong, Sarinee

doi:10.1016/j.bbr.2008.10.043

Cited by 40 publications

(31 citation statements)

References 45 publications

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“…phobia, panic, and generalized anxiety (Pandaranandaka et al, 2009); and no single animal model can adequately take into account all of the complex aspects of mood and anxiety disorders, converging evidence from more than one animal model that tests anxiety is required (Henderson et al, 2004). Elevated plus maze was to assess the panic anxiety-like state of animal presented in elevated open arms.…”

Section: Discussionmentioning

confidence: 99%

Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice

Yang

Wang

et al. 2015

Chemosphere

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Section: Discussionmentioning

confidence: 99%

Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice

Yang

Wang

et al. 2015

Chemosphere

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“…The increased anxiety state is accompanied by the decreased levels of E 2 with age (Walf and Frye, 2010). Physiological E 2 -replacement reduced the ovariectomy (ovx)-induced anxiety-and depression-like behaviors in female rodents (Frye et al, 2000;Pandaranandaka et al, 2009). However, a longer E 2 -replacement regimen and/or a higher E 2 dosage (>physio-logical concentration) did not reduce the ovx-induced anxiety and/ or depression (Walf and Frye, 2005).…”

Section: The Effects Of Bpa Exposure On Anxiety-and Depression-like Bmentioning

confidence: 99%

Gestational and lactational exposure to bisphenol-A affects anxiety- and depression-like behaviors in mice

Xiao

Xie

et al. 2012

Hormones and Behavior

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“…It has been repeatedly demonstrated that estrogen, a family of sex hormones exhibitingan antidepressant-like action, induces TPH2 gene expression [71, 72]. Accordingly, estrogen regulation of TPH2 expression may contribute, at least in part, to its antidepressant-like action, as well as sex-related differences in TPH2 expression [18] and stress-related behavioral traits [73].…”

Section: Tph2 As An Emerging Therapeutic Target For Stress Disordersmentioning

confidence: 99%

“…Indeed, estrogen-induced tph2 expression in rat midbrain was associated with anxiety behavior [71], while over-expression or knockdown of rat tph2 exerted an estrogen-dependent effect on anxiety behavior [70]. Notably, exogenous and endogenous estrogen may exert opposite effects on TPH2 expression, which may account for the differential effects of exogenous (anxiolytic) and endogenous (panicolytic) estrogen on anxiety [72]. …”

Section: Tph2 As An Emerging Therapeutic Target For Stress Disordersmentioning

confidence: 99%

Tryptophan hydroxylase-2: An emerging therapeutic target for stress disorders

Chen

Miller

2013

Biochemical Pharmacology

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Serotonin (5-HT) has been long recognized to modulate the stress response, and dysfunction of 5-HT has been implicated in numerous stress disorders. Accordingly, the 5-HT system has been targeted for the treatment of stress disorders. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in 5-HT synthesis, and the recent identification of a second, neuron-specific TPH isoform (TPH2) opened up a new area of research. With a decade of extensive investigation, it is now recognized that: 1) TPH2 exhibits a highly flexible gene expression that is modulated by an increasing number of internal and external environmental factors including the biological clock, stressors, endogenous hormones, and antidepressant therapies; and 2) genetically determined TPH2 activity is linked to a growing body of stress-related neuronal correlates and behavioral traits. These findings reveal an active role of TPH2 in the stress response and provide new insights into the long recognized but not yet fully understood 5-HT-stress interaction. As a major modulator of 5-HT neurotransmission and the stress response, TPH2 is of both pathophysiological and pharmacological significance, and is emerging as a new therapeutic target for the treatment of stress disorders. Given that numerous antidepressant therapies influence TPH2 gene expression, TPH2 is already inadvertently targeted for the treatment of stress disorders. With increased understanding of the regulation of TPH2 activity we can now purposely utilize TPH2 as a target to develop new or optimize current therapies, which are expected to greatly improve the prevention and treatment of a wide variety of stress disorders.

show abstract

Differential effects of exogenous and endogenous estrogen on anxiety as measured by elevated T-maze in relation to the serotonergic system

Cited by 40 publications

References 45 publications

Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice

Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice

Gestational and lactational exposure to bisphenol-A affects anxiety- and depression-like behaviors in mice

Tryptophan hydroxylase-2: An emerging therapeutic target for stress disorders

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