Differential Effects of Estradiol on Reproductive Function in Camelids

Carrasco, Rodrigo A.; Ratto, M.H.; Adams, Gregg P.

doi:10.3389/fvets.2021.646700

Cited by 1 publication

(1 citation statement)

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“…β-NGF-induced prostaglandins secretion would then directly or indirectly stimulate (via local chemical mediators) uterine/cervix neurons that reach, via spinal cord afferent pathways, the hypothalamic centres responsible for the LH surge that induces ovulation). Likewise, an influence of both estradiol and NGF on gonadotrophin secretion in other induced ovulators such as camelids has been reported (Carrasco et al, 2021). However, in the case of rabbits, only a luteotrophic effect of estradiol has been evidenced by preventing apoptosis in luteal cells (Goodman et al, 1998), also demonstrated by the decreased expression of luteal type 1 oestrogen receptor in PGF2a-induced luteolysis (Maranesi et al, 2010).…”

Section: Sp B-ngfmentioning

confidence: 96%

Physiology and modulation factors of ovulation in rabbit reproduction management

et al. 2021

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Rabbit is an induced ovulatory species, so ovulation takes place after mating. Traditionally, exogenous and synthetic hormonal factors (administered by intramuscular and intravaginal route) such as GnRH and analogues, or different physical procedures (i.e. stimulation by intravaginal cannula) have been used to induce ovulation in females when artificial insemination is applied in rabbit farms. Restriction and public rejection of the use of hormones is leading to the study of the seminal plasma components with potential action on ovulation induction. The aim of the present review is to collect and summarise the strategies used in recent years to trigger ovulation and improve rabbit fertility management with respect to more animal-friendly manipulation methods. Furthermore, special attention has been paid to the use of a semen component (as endogen molecule) such as beta nerve growth factor (β-NGF) in male and female rabbit reproductive physiology. This neurotrophin and its receptors (TrKA and p75NTR) are abundantly distributed in both male and female rabbit reproductive tracts, and it seems to have an important physiological role in sperm maturation and behaviour (velocity, apoptosis and capacitation), as well as a modulatory factor of ovulation. Endogen β-NGF is diluted in the seminal doses with the extenders; hence it could be considered an innovative and alternative strategy to avoid the current exogenous (by intramuscular route) and stressful hormonal treatments used in ovulation induction. Their addition in seminal dose could be more physiological and improve animal welfare in rabbit farms.

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Section: Sp B-ngfmentioning

confidence: 96%