Differential Effects of Cyclosporine and Tacrolimus on Arterial Function

Seibert, Felix S.; Behrendt, Carolin; Schmidt, Sven; Giet, Markus van der; Zidek, Walter; Westhoff, Timm H.

doi:10.1097/00004872-201106001-01440

Cited by 4 publications

(8 citation statements)

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“…Sixty-four patients were enrolled in the study (60 cadaveric grafts, 4 live donor transplantations). Some of these patients underwent cardiovascular profiling as published previously [11]. Epidemiological information, data on transplantation and graft function, cause of ESRD, concomitant diseases, and traditional cardiovascular risk factors are presented in Table 1.…”

Section: Patients and Methods Study Population And Protocolmentioning

confidence: 99%

“…Hemodynamic measurements were conducted in a quiet clinical research laboratory at a constant ambient temperature of 20 to 22 C between 12 and 14 AM, at least 3 hours and on average 4 to 6 hours after ingestion of CNI as published previously [11,12]. Because CNI levels might acutely influence arterial elasticity, all the measurements were performed at this defined span of time to assure comparability of results.…”

Section: Assessment Of Pwv and Ai 75mentioning

confidence: 99%

“…Applanation tonometry was performed using a SphygmoCor device (AtCor Medical, Sidney, Australia) as recommended [13]. This device has been successfully used in renal transplant recipients before [11]. In brief, recording of radial pressure waveforms was performed using a highfidelity micromanometer placed on the tip of a hand-held tonometer (Millar Instruments, Houston, Tex, United States), which was applied to the surface of the skin overlying the radial artery at the nonfistula arm.…”

Section: Assessment Of Pwv and Ai 75mentioning

confidence: 99%

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Prediction of Cardiovascular Events After Renal Transplantation

Seibert

Behrendt

Pagonas

et al. 2015

Transplantation Proceedings

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Section: Patients and Methods Study Population And Protocolmentioning

confidence: 99%

Section: Assessment Of Pwv and Ai 75mentioning

confidence: 99%

Section: Assessment Of Pwv and Ai 75mentioning

confidence: 99%

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Prediction of Cardiovascular Events After Renal Transplantation

Seibert

Behrendt

Pagonas

et al. 2015

Transplantation Proceedings

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“…On the other hand, the extended length of immunosuppressant therapy (ie, cyclosporine, tacrolimus) after a transplant may increase arterial stiffness and reduce the elasticity, increasing vascular fragility 15. All these elements may have contributed to the pathogenesis of aortic dissection in our patient.…”

mentioning

confidence: 89%

An atypical case of Stanford type‐A chronic aortic dissection managed conservatively

et al. 2019

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Stanford type‐A aortic dissection is a clinical emergency; mortality is high, and surgery is urgently required in most cases. Chronic forms of type‐A dissection are rare and have a poor prognosis if not treated surgically. We present an unusual case of chronic type‐A aortic dissection, with silent onset, in an oncologic patient without risk factors, which was managed conservatively and remained substantially stable during follow‐up.

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“…469 There are both experimental and clinical differences between cyclosporine and tacrolimus, since the latter has a lower incidence of hypertension, likely due to the lower systemic vasoconstriction caused by tacrolimus. 465,[470][471][472] Ca 2+ channel antagonists are considered to be the best treatment.…”

Section: Calcineurin Inhibitorsmentioning

confidence: 99%

Comprehensive review of cardiovascular toxicity of drugs and related agents

Mladěnka

Applová

Patočka

et al. 2018

Medicinal Research Reviews

207

120

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Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta‐blockers, calcium channel blockers, female hormones, nonsteroidal anti‐inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.

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Differential Effects of Cyclosporine and Tacrolimus on Arterial Function

Cited by 4 publications

References 0 publications

Prediction of Cardiovascular Events After Renal Transplantation

Prediction of Cardiovascular Events After Renal Transplantation

An atypical case of Stanford type‐A chronic aortic dissection managed conservatively

Comprehensive review of cardiovascular toxicity of drugs and related agents

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