Differential Effects of Cyclodextrin Derivatives on Aggregation and Thermal Behavior of Insulin

Tokihiro, Keiichi; Irie, Tetsumi; Uekama, Kaneto

doi:10.1007/978-94-011-5448-2_79

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Hydrophilic Cyclodextrins As Solubilizers and Stabilizers1

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2001

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Cited by 3 publications

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“…In such a case, the electrostatic interaction between the positive charges of insulin and the negative charges of the sulfonate group of sulfobutyl-β-cyclodextrin seems to be more of a factor than the inclusion effects. These results suggest that proper use of the hydrophilic cyclodextrins could be effective in designing rapid or long-acting insulin preparations …”

Section: Hydrophilic Cyclodextrins As Solubilizers and Stabilizersmentioning

confidence: 91%