Differential effects of cortical ablation and spreading depression on sensitivity to footshock: Implications for the role of the cortex in learning

Best, Phillip J.; Orr, James; Pointer, James E.

doi:10.1016/0031-9384(75)90073-6

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Unilateral cortical spreading depression (CSD) is a selfpropagating wave of cellular depolarization followed by a marked enduring reduction of spontaneous electrical activity (Leao 1944;Smith et al 2006). CSD is a transient phenomenon, can be experimentally localized to the cortical hemisphere where it is induced, and has been widely used to induce functional decortication (Shibata and Bures 1974;Best et al 1975;Monda et al 2000). The mechanisms underlying CSD induction and propagation remain unclear (Lauritzen 1994).…”

Section: Introductionmentioning

confidence: 99%

Unilateral Cortical Spreading Depression Affects Sleep Need and Induces Molecular and Electrophysiological Signs of Synaptic Potentiation In Vivo

Faraguna¹,

Nelson

Vyazovskiy³

et al. 2010

Cerebral Cortex

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Cortical spreading depression (CSD) is an electrophysiological phenomenon first described by Leao in 1944 as a suppression of spontaneous electroencephalographic activity, traveling across the cerebral cortex. In vitro studies suggest that CSD may induce synaptic potentiation. One recent study also found that CSD is followed by a non-rapid eye movement (NREM) sleep duration increase, suggesting an increased need for sleep. Recent experiments in animals and humans show that the occurrence of synaptic potentiation increases subsequent sleep need as measured by larger slow wave activity (SWA) during NREM sleep, prompting the question whether CSD can affect NREM SWA. Here, we find that, in freely moving rats, local CSD induction increases corticocortical evoked responses and strongly induces brain derived neurotrophic factor (BDNF) in the affected cortical hemisphere but not in the contralateral one, consistent with synaptic potentiation in vivo. Moreover, for several hours after CSD, large slow waves occur in the affected hemisphere during rapid eye movement sleep and quiet waking but disappear during active exploration. Finally, we find that CSD increases NREM sleep duration and SWA, the latter specifically in the affected hemisphere. These effects are consistent with an increase in synaptic strength triggered by CSD, although nonphysiological phenomena associated with CSD may also play a role.

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Section: Introductionmentioning

confidence: 99%

Unilateral Cortical Spreading Depression Affects Sleep Need and Induces Molecular and Electrophysiological Signs of Synaptic Potentiation In Vivo

Faraguna¹,

Nelson

Vyazovskiy³

et al. 2010

Cerebral Cortex

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show abstract

“…Some investigators have found that bilateral depression prevents animals from learning an avoidance response to shock (Plotkin, 1967;Travis & Sparks, 1963), whereas others have found that it does not (Best, Orr, & Pointer, 1975;Schneider, 1966;Thompson & Enter, 1967). Some investigators have found that bilateral depression prevents animals from learning an avoidance response to shock (Plotkin, 1967;Travis & Sparks, 1963), whereas others have found that it does not (Best, Orr, & Pointer, 1975;Schneider, 1966;Thompson & Enter, 1967).…”

Section: Stimulus Properties Of Depressionmentioning

confidence: 99%

Spreading Depression: A Behavioral Analysis

Schneider

1983

The Physiological Basis of Memory

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Gap junctions and memory: An investigation using a single trial discrimination avoidance task for the neonate chick

Verwey

Edwards

2010

Neurobiology of Learning and Memory

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Differential effects of cortical ablation and spreading depression on sensitivity to footshock: Implications for the role of the cortex in learning

Cited by 4 publications

References 16 publications

Unilateral Cortical Spreading Depression Affects Sleep Need and Induces Molecular and Electrophysiological Signs of Synaptic Potentiation In Vivo

Unilateral Cortical Spreading Depression Affects Sleep Need and Induces Molecular and Electrophysiological Signs of Synaptic Potentiation In Vivo

Spreading Depression: A Behavioral Analysis

Gap junctions and memory: An investigation using a single trial discrimination avoidance task for the neonate chick

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