Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior

Rumanova, Valentina Sophia; Okuliarova, Monika; Zeman, Michal

doi:10.3390/ijms21155478

Cited by 60 publications

(32 citation statements)

References 114 publications

(232 reference statements)

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“…Previous reports that investigated the long-term CL exposure in rats mentioned a decrease in body weight gain [ 5 ], increase in body mass [ 6 ], or no change in body weight [ 1 , 7 , 8 , 9 ]. Food intake during CL or dim light exposures showed a similar controversy [ 10 ]. The light/dark cycle can also affect the energy expenditure by modulation of the SCN and consequent effects on the peripheral clocks in the liver, intestine, and pancreas via autonomic signals and the release of hormones [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Long-Term Continuous Light Exposure and Western Diet on Adropin Expression, Lipid Metabolism, and Energy Homeostasis in Rats

Abulmeaty

Almajwal

Al‐Numair

et al. 2021

Biology

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Long-term continuous light exposure (CL) and western diet (WD) effects on Adropin expression, RORα, and Rev-erb-α nuclear receptors and energy homeostasis were studied in rats. Thirty-two male Wistar rats (250–290 g) were enrolled for 3 months in the following groups (n = 8/group): (a) Normal control group (NC), (b) CL group, (c) WD group, and (d) CL + WD group. Then, indirect calorimetry and food intake (FI) were measured. Finally, Adropin, hormone-sensitive lipase (HSL), adipocyte triglyceride lipase (ATGL), and free fatty acids (FFA) were measured. Additionally, the histopathology and gene expression of Enho, RORα, and Rev-erb-α genes were done. The CL alone elevated the Adropin plasma level and gene expression, increased RORα expression, and decreased the Rev-erb-α nuclear receptor expression mainly in the liver and kidney. Besides, CL increased the total energy expenditure (TEE) and decreased the respiratory quotient. WD alone or in combination with the CL reversed gene expression of Enho, RORα, and Rev-erb-α. Combined CL and WD increased the TEE, reduced the food intake, increased the ATGL, and reduced the Adropin level in addition to widespread degenerative changes in the liver, spleen, and renal tissues. The deleterious effects of CL and WD on energy homeostasis may include Adropin with the involvement of the RORα and Rev-erb-α nuclear receptors.

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Section: Introductionmentioning

confidence: 99%

Effect of Long-Term Continuous Light Exposure and Western Diet on Adropin Expression, Lipid Metabolism, and Energy Homeostasis in Rats

Abulmeaty

Almajwal

Al‐Numair

et al. 2021

Biology

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“…In an experimental study conducted with an ALAN level of 2 lux, an impaired balance of lipid biosynthetic pathways has been demonstrated in rodents and in mosquitoes but exposed to 300 lux at night (Honnen et al, 2016). ALAN-related disruption of circadian rhythmicity through a modification of the expression of clock genes has been suggested to be involved in this impairment (Fonken & Nelson, 2014;Rumanova et al, 2020). As in the majority of organisms, in amphibians, lipid metabolic activity occurs mainly in the liver and its regulation is based on the balance between the synthesis of fatty acids and fat catabolism (Sheridan, 1994).…”

Section: Discussionmentioning

confidence: 99%

Large-scale deregulation of gene expression by artificial light at night in tadpoles of common toads

Touzot

Lefébure

Lengagne

et al. 2021

Preprint

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Artificial light at night (ALAN) affects numerous physiological and behavioural mechanisms in various species by potentially disturbing circadian timekeeping systems. Although gene-specific approaches have already shown the deleterious effect of ALAN on the circadian clock, immunity and reproduction, large-scale transcriptomic approaches with ecologically relevant light levels are still lacking to assess the global impact of ALAN on biological processes. Moreover, studies have focused mainly on variations in gene expression during the night in the presence of ALAN but never during the day. In a controlled laboratory experiment, transcriptome sequencing of Bufo bufo tadpoles revealed that ALAN affected gene expression at both night and daytime with a dose-dependent effect and globally induced a downregulation of genes. ALAN effects were detected at very low levels of illuminance (0.1 lux) and affected mainly genes related to the innate immune system and, to a lesser extend to lipid metabolism. These results indicate that a broad range of physiological pathways is impacted at the molecular level by very low levels of ALAN potentially resulting in reduced survival under environmental immune challenges.

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“…It should be stressed that in our experiment, birds were kept under complete darkness during the scotophase, which may increase effectivity of dim light in the control of pineal rhythmicity. Recent studies show the significance of darkness at night in many aspects of animal physiology [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolism of Melatonin Synthesis-Related Indoles in the Turkey Pineal Organ and Its Modification by Monochromatic Light

Martyniuk

Hanuszewska

Lewczuk

2020

IJMS

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The metabolism of pineal indoles is closely related to alterations in the light and dark phases of a daily cycle. Recent research showed important interspecies differences in the pineal biochemistry, and a strong impact of monochromatic light on many physiological processes in birds. Therefore, the aims of study were to characterize the metabolism of melatonin-synthesis indoles in the pineal organ of the domestic turkey, and to determine the changes occurring in this metabolism under the influence of different wavelengths and intensities of light. For this purpose, 3-week-old turkeys were kept under 16 lx white light, or under blue, green, and red light with intensities of 16, 32, and 64 lx during the photophase, and after 7 d were sacrificed at 4 h intervals. The activities of melatonin-synthesizing enzymes and the contents of indoles were measured in the same pineal organ. The results revealed that the activities of tryptophan hydroxylase and arylalkylamine N-acetyltransferase, and the levels of all tryptophan derivatives had significant daily changes in birds kept under each light condition used. The profile of pineal indole metabolism in 4-week-old turkeys was characterized by high-amplitude rhythms in the activity of arylalkylamine N-acetyltransferase and the contents of N-acetylserotonin and melatonin, equal relative amounts of serotonin and 5-hydroxyindoleacetic acid, and higher content of melatonin than N-acetylserotonin. The monochromatic light significantly modified the pineal indole metabolism, and its effects were dependent on the color and intensity of light. Pronounced changes occurred in the level of serotonin synthesis and the daily rhythm course of melatonin synthesis.

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Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior

Cited by 60 publications

References 114 publications

Effect of Long-Term Continuous Light Exposure and Western Diet on Adropin Expression, Lipid Metabolism, and Energy Homeostasis in Rats

Effect of Long-Term Continuous Light Exposure and Western Diet on Adropin Expression, Lipid Metabolism, and Energy Homeostasis in Rats

Large-scale deregulation of gene expression by artificial light at night in tadpoles of common toads

Metabolism of Melatonin Synthesis-Related Indoles in the Turkey Pineal Organ and Its Modification by Monochromatic Light

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