Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4

Abstract

CYP or P450, a generic term for a cytochrome P450 enzyme, individual P450s are identified using a number-letter-number format based on amino acid sequence relatedness; Fc, calculated structure factor; Fo, observed structure factor; PDB, Protein Data Bank, specific entries are indicated by PDB: followed by 4 alphanumeric symbols; PEG, polyethylene glycol; PMSF, phenylmethylsulfonyl fluoride; SSRL, Stanford Synchrotron Radiation Lightsource.