Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines

Ifere, Godwin O.; Barr, Erika; Equan, Anita; Gordon, Kereen; Singh, Udai P.; Chaudhary, Jaideep; Igietseme, Joseph U.; Ananaba, Godwin A.

doi:10.1016/j.cdp.2008.12.002

Cited by 65 publications

(47 citation statements)

References 36 publications

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“…that the inhibitory effects of g-oryzanol in cell growth occurs via induction of G0/G1 arrest in DU145 cells or G2/M arrest in LNCaP and PC3 cells, as similarly reported by others with the incubation with different phytosterols [18,26]. One of the pathways that is activated through cell cycle progression is ERK1/2 activation.…”

Section: The Prostatesupporting

confidence: 53%

“…Currently evidence shows that g-oryzanol has anticarcinogenic activity [40] against breast, lung, liver and colorectal cancer through its ability to induce apoptosis, inhibit cell proliferation and alter cell cycle progression [45]. Moreover, its components, such as phytosterols, also act on prostate cancer cell lines downregulating the expression of cav-1 and PCGEM1, a prostate specific gene [18,41].Actually, it is known that the evolution of cancer is associated with deregulated cellular proliferation and suppressed cell death [42]. The concentration of g-oryzanol used in this work was able to reduce cell viability and cell population in the three cell lines studied.…”

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confidence: 99%

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γ‐oryzanol reduces caveolin‐1 and PCGEM1 expression, markers of aggressiveness in prostate cancer cell lines

et al. 2015

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Section: The Prostatesupporting

confidence: 53%

mentioning

confidence: 99%

γ‐oryzanol reduces caveolin‐1 and PCGEM1 expression, markers of aggressiveness in prostate cancer cell lines

et al. 2015

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“…On the other hand, there are numerous references about the phytosterols cytotoxicity activities against several human cancer cells [8, 9]. For example, it has been reported that 2 inhibited the MDA-MB-231 cell growth by 70% compared with control and induced cell cycle arrest at the G2/M phase.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sterols Isolated fromMyrtillocactus geometrizanson Growth Inhibition of Colon and Breast Cancer Cells

Bolaños-Carrillo

Ventura-Gallegos

Saldivar-Jiménez

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effect of peniocerol and macdougallin on HCT-15 and MCF-7 cells proliferation, cell cycle, apoptosis, and PARP cleavage. Methods. HCT-15 and MCF-7 cells were treated with various concentrations of peniocerol and macdougallin (10–80 μM) during 24 or 48 h. Crystal Violet Assay was used to evaluate the inhibition effect. Cell cycle regulation was examined by a propidium iodide method. Cell apoptosis was detected through both Annexin–V FLUOS/PI double-labeled cytometry assays and Western blot was applied to assess PARP cleavage. Results. Peniocerol and macdougallin induced growth inhibition and apoptosis in vitro in a time- and dose-dependent manner. Moreover, peniocerol and macdougallin induced arrest of cell cycle-dependent manner and increased the proportion of cells in G0/G1 phase. PARP cleavage in HCT-15 and MCF-7 cells was induced by treatment with peniocerol and macdougallin after 36 hours. Conclusions. Our results showed that the mechanism of cytotoxicity displayed by peniocerol and macdougallin is related to cell cycle arrest and apoptosis in both cell lines. This is a significant observation because it helps to understand the way some oxysterols isolated from Myrtillocactus geometrizans develop their biological activities against cancer cells.

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“…Furthermore, Ifere et al found that PCGEM1 can be regulated by sterol. They also suggested PCGEM1 as a biomarker for the prediction of tumors that would be responsive to chemoprevention by phytosterols [124].…”

Section: Uca1 Is Regulated By Ets-2 and Hif-1αmentioning

confidence: 99%

Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer

2014

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Different long non-coding RNAs (lncRNAs) are transcribed within the genome. Although initially argued to be spurious transcriptional noise, these RNAs play important roles in biological pathways, as shown by different studies. Also, there are some reports about the role of lncRNAs in different cancers. They can contribute to the development and progression of cancer by the functioning as oncogene or/and tumor suppressor molecules. In this review, we point to some important lncRNAs as examples which seem to be involved in cancer initiation/progression.

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Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines

Cited by 65 publications

References 36 publications

γ‐oryzanol reduces caveolin‐1 and PCGEM1 expression, markers of aggressiveness in prostate cancer cell lines

γ‐oryzanol reduces caveolin‐1 and PCGEM1 expression, markers of aggressiveness in prostate cancer cell lines

Effect of Sterols Isolated fromMyrtillocactus geometrizanson Growth Inhibition of Colon and Breast Cancer Cells

Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer

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