Differential effects of chlordiazepoxide on aggressive behavior in male mice: the influence of social factors

Ferrari, Pier Francesco; Parmigiani, Stefano; Rodgers, R.J.; Palanza, Paola

doi:10.1007/s002130050448

Cited by 45 publications

(38 citation statements)

References 40 publications

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“…Previous reports demonstrated that anxiolytic drugs affected aggressive behaviors [4,14,16], and aggression is known to occur in association with anxiety. For example, dominant mice, i.e., those from aggressive strains or winners in social confrontations, also have high anxiety levels [3,5,10]. In the present study we found that the latency to the first attack bite was longer in the EW.…”

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confidence: 51%

The Influence of Early Weaning on Aggressive Behavior in Mice

et al. 2003

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ABSTRACT. Early postnatal experiences have been shown to have a tremendous influence on behavior development. In this study, we focused on weaning time and investigated the effects of early weaning on adulthood aggressive behavior in mice with the residentintruder test. Early weaning resulted in decreased sideways threat and tail rattle. In addition, the frequency of attack bites was more variable in the early weaned group, although the mean frequency did not differ from the normally weaned group. The results of the present study suggest that aggressive behavior is also affected by early weaning manipulation. KEY WORDS: aggression, early environment, weaning.J. Vet. Med. Sci. 65(12): 1347-1349, 2003 Development of the behavioral repertoire is greatly influenced by the early postnatal environment in various mammalian species. In particular, mother-pup interactions play an important role in the development of instinctive behavior [1,8,11,12,17,19]. In rats, for instance, a lower level of maternal care or long-term maternal deprivation increases responsiveness to various stressors and anxiety-related behavior, whereas the same deprivation suppresses the manifestation of social behavior [1,8,12,19]. Rhesus monkeys that received less maternal care also exhibit exaggerated fear responses and emotional behavior [11,17].Weaning is one of the most important experiences in the early life of mammalian species. Early weaning from the mother led to a decrease in play-fighting and to an increase in anxiety-related behavior in juvenile rats [6,7]. Similarly, a decrease in social seeking behaviors has been reported in mice [18]. Recently, we have found that early weaning results in a persistent increase in anxiety in mice [9]. This finding suggested that the timing of weaning has a long-lasting influence on various aspects of behavioral development, in addition to the direct effects observed during the neonatal and/or juvenile stages of life.As for aggressive behavior, however, there is only limited information about the effects of timing of weaning and the postnatal environment. We have previously found that male mice weaned earlier than normally weaned mice have a greater number of wounds on their tails when co-housed with male mice that had been manipulated in the same manner [9]. This finding implies that the level of aggression may have been heightened by the early weaning manipulation but we could not detect the attack bite behavior in isolation-induced aggression tests. One possible explanation for why the laboratory mice were not very aggressive in the isolation-induced aggression test was the fact that sexually naive mice were used in the previous study, and such mice have been reported to show low levels of aggression [2,15]. The purpose of the present study was to investigate the effects of early weaning on aggressive behavior exhibited in adulthood after the males were paired with females for 3 weeks. The resident-intruder test was adopted for the study, as it was considered to be suitable for assessing the natural ...

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confidence: 51%

The Influence of Early Weaning on Aggressive Behavior in Mice

et al. 2003

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“…One of the aims of this study was to establish whether or not the effects of the two drugs in question differed between adolescent and adult mice, as social deprivation in early stages of development may also have profound consequences on adult social behavior [Ferrari et al, 1997]. Therefore, we studied behavioral changes induced by a 15-day isolation period in both adolescent and adult mice; a period that obviously initiates at a different time in each age group.…”

Section: Discussionmentioning

confidence: 99%

Differential sensitivity to the effects of nicotine and bupropion in adolescent and adult male OF1 mice during social interaction tests

Gómez

Carrasco

Redolat

2008

Aggressive Behavior

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Few studies have compared the action of both nicotine (NIC) and bupropion (BUP), an antidepressant used to treat NIC dependence, on social and aggressive behavior at different ages. This study aims to determine whether these drugs produce differential effects in adolescent (postnatal day: 36-37) and adult (postnatal day: 65-66) mice that have been housed individually for 2 weeks in order to induce aggressive behavior. Mice received BUP (40, 20, or 10 mg/kg), NIC (1, 0.5, and 0.25 mg/kg as base), or vehicle earlier to a social interaction test. BUP (40 mg/kg) decreased social investigation and increased nonsocial exploration in both adolescent and adult mice. The same effects were also observed in adult mice administered with a lower dose of the same drug (20 mg/kg). In adolescents, NIC (1 mg/kg) decreased social investigation, but this effect did not reach statistical significance in adults. In conclusion, a differential sensitivity to the effects of NIC or BUP emerged in some of the behavioral categories when the two age groups were compared.

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“…For example, the prototypic BZ, chlordiazepoxide, increases aggression in male rats toward opponents, an effect that has been replicated in male mice and in lactating mice (Miczek 1974;Rodgers and Waters 1985;Weerts et al 1992;Palanza et al 1996;Ferrari et al 1997). Chlordiazepoxide prolongs aggressive encounters between male rats and increases threat displays and aggressive vocalizations in squirrel monkeys (Miczek 1974;Beck and Cooper 1986;Weerts and Miczek 1996).…”

Section: Introductionmentioning

confidence: 93%