Differential effects of childhood trauma subtypes on fatigue and physical functioning in chronic fatigue syndrome

Venter, Maud De; Illegems, Jela; Royen, Rita Van; Moorkens, Greta; Sabbe, Bernard; Eede, Filip Van Den

doi:10.1016/j.comppsych.2017.07.006

Cited by 12 publications

(11 citation statements)

References 55 publications

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“…It should be noted that these findings could at least in part be due to an overlap with comorbid or misdiagnosed depression (14). In the present study, we used the BDI-II-FastScreen to overcome the shortcoming of a symptom overlap (i.e.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in Multiple Sclerosis Is Associated With Childhood Adversities

et al. 2020

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Fatigue is a common and disabling symptom in patients with Multiple Sclerosis (PwMS). Its pathogenesis, however, is still not fully understood. Potential psychological roots, in particular, have received little attention to date. The present study examined the association of childhood adversities, specific trait characteristics, and MS disease characteristics with fatigue symptoms utilizing path analysis. Five hundred and seventyone PwMS participated in an online survey. Standardized psychometric tools were applied. The Childhood Trauma Questionnaire (CTQ) served to assess childhood adversities. Trait variables were alexithymia (Toronto Alexithymia Scale; TAS-26) and early maladaptive schemas (Young Schema Questionnaire; YSQ). Current pathology comprised depression (Beck's Depression Inventory FastScreen; BDI-FS) and anxiety symptoms (State-Trait Anxiety Inventory; STAI-state), as well as physical disability (Patient determined Disease Steps; PDDS). The Fatigue Scale for Motor and Cognitive Functions (FSMC) was the primary outcome variable measuring fatigue. PwMS displayed high levels of fatigue and depression (mean FSMC score: 72; mean BDI-II score: 18). The final path model revealed that CTQ emotional neglect and emotional abuse remained as the only significant childhood adversity variables associated with fatigue. There were differential associations for the trait variables and current pathology: TAS-26, the YSQ domain impaired autonomy and performance, as well as all current pathology measures had direct effects on fatigue symptoms, accounting for 28.2% of the FSMC variance. Bayesian estimation also revealed indirect effects from the two CTQ subscales on FSMC. The final model fitted the data well, also after a cross-validation check and after replacing the FSMC with the Chalder Fatigue Questionnaire (CFQ). This study suggests an association psychological factors on fatigue in Multiple Sclerosis. Childhood adversities, as well as specific trait characteristics, seem to be associated with current pathology and fatigue symptoms. The article discusses potential implications and limitations.

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Section: Discussionmentioning

confidence: 99%

Fatigue in Multiple Sclerosis Is Associated With Childhood Adversities

et al. 2020

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“…However, evidence on a cognitive-behavioral level suggests the existence of differential effects of trauma subtypes (e.g., sexual abuse and emotional neglect) as well. In chronic fatigue syndrome, sexual abuse was the only childhood trauma subtype predictive of fatigue symptoms and physical functioning ( 11 ). Physical trauma types (i.e., physical abuse or neglect) and sexual abuse have been associated with reduced executive functioning, working memory, and intelligence scores in a psychiatric population ( 12 ) as well as reduced cognitive flexibility in healthy adults ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Structural and Functional Brain Abnormalities Associated With Exposure to Different Childhood Trauma Subtypes: A Systematic Review of Neuroimaging Findings

et al. 2018

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Background: Childhood trauma subtypes sexual abuse, physical abuse, emotional maltreatment, and neglect may have differential effects on the brain that persist into adulthood. A systematic review of neuroimaging findings supporting these differential effects is as yet lacking.Objectives: The present systematic review aims to summarize the findings of controlled neuroimaging trials regarding long-term differential effects of trauma subtypes on the human brain.Methods: A systematic literature search was performed using the PubMed and PsycINFO databases from January 2017 up to and including January 2018. Additional papers were identified by a manual search in the reference lists of selected papers and of relevant review articles retrieved by the initial database search. Studies were then assessed for eligibility by the first author. Only original human studies directly comparing neuroimaging findings of exposed and unexposed individuals to well-defined emotional, physical or sexual childhood maltreatment while controlling for the effects of other subtypes were included. A visual summary of extracted data was made for neuroimaging modalities for which comparison between trauma subtypes was feasible, taking the studies' numbers and sample sizes into account.Results: The systematic literature search yielded 25 publications. Sexual abuse was associated with structural deficits in the reward circuit and genitosensory cortex and amygdalar hyperreactivity during sad autobiographic memory recall. Emotional maltreatment correlated with abnormalities in fronto-limbic socioemotional networks. In neglected individuals, white matter integrity and connectivity were disturbed in several brain networks involved in a variety of functions. Other abnormalities, such as reduced frontal cortical volume, were common to all maltreatment types.Conclusions: There is some evidence for long-term differential effects of trauma subtypes on the human brain. The observed alterations may result from both protective adaptation of and damage to the brain following exposure to threatening life events. Though promising, the current evidence is incomplete, with few brain regions and neuroimaging modalities having been investigated in all subtypes. The comparability of the available evidence is further limited by the heterogeneity of study populations regarding gender, age and comorbid psychopathology. Future neuroimaging studies should take this potentially differential role of childhood trauma subtypes into account.

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“…CTQ scores below and above the median were used to define lesser and higher occurrence of trauma, respectively. To analyze the childhood trauma subtypes, 2 different measures were used: the first measure consisted of the occurrence or nonoccurrence of each childhood trauma subtype (binary measure), and the second measure was defined according to the severity of the trauma subtype (no [score = 5], mild [6][7][8][9][10], moderate [11][12][13][14][15], or intense [16][17][18][19][20][21][22][23][24][25]). 46 For the BAI and BDI measures, analyses were performed that considered the standard cutoff point of the questionnaires in the Brazilian population.…”

Section: Discussionmentioning

confidence: 99%

“…Bower et al 16 found that emotional neglect was positively associated with high fatigue levels in patients with breast cancer. 9,20,21 So far, only 1 study has investigated the occurrence of childhood trauma in patients with HNC. In the general population, studies have also shown that subcategories of childhood trauma have a significant impact on the occurrence of emotional and physical disorders.…”

Section: Introductionmentioning

confidence: 99%

“…In the general population, studies have also shown that subcategories of childhood trauma have a significant impact on the occurrence of emotional and physical disorders. 9,20,21 So far, only 1 study has investigated the occurrence of childhood trauma in patients with HNC. 22 Archer et al 22 found that patients with HNC reported more severe levels of childhood adversity and higher levels of depression than patients with colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

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