Differential effects of antipsychotics on expression of antioxidant enzymes and membrane lipid peroxidation in rat brain

Parikh, Vinay; Khan, Mohammad M.; Mahadik, Sahebarao P.

doi:10.1016/s0022-3956(02)00048-1

Cited by 201 publications

(119 citation statements)

References 36 publications

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“…These findings mirror significant increases in oxidative damage markers found in animals induced by haloperidol but not by SGAs (e.g. Parikh et al 2003) as well as in schizophrenic patients (e.g. Zhang et al 2006).…”

Section: Letter To the Editorsupporting

confidence: 70%

Letter to the Editor: Haloperidol but not dopamine rapidly induces neuronal death: comments on ‘A systematic review of the effects of antipsychotic drugs on brain volume’

Grant

2013

Psychol. Med.

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Section: Letter To the Editorsupporting

confidence: 70%

Letter to the Editor: Haloperidol but not dopamine rapidly induces neuronal death: comments on ‘A systematic review of the effects of antipsychotic drugs on brain volume’

Grant

2013

Psychol. Med.

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“…SOD can catalyze O 2 − disproportionately into H 2 O 2 and O 2 (Lewis et al, 1995;Tian et al, 2011). MDA is a product of lipid peroxidation, which is often used as a bio-marker of tissue oxidative stress and cell damage (Parikh et al, 2003;Wu et al, 2012). There were no significant differences in MDA and T-AOC levels among the different groups in this study.…”

Section: Discussionmentioning

confidence: 53%

Influence of dietary taurine and housing density on oviduct function in laying hens

Dai

Zhang

Zhi-gang

et al. 2015

J. Zhejiang Univ. Sci. B

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Experiments were conducted to study the effects of dietary taurine and housing density on oviduct function in laying hens. Green-shell laying hens were randomly assigned to a free range group and two caged groups, one with low-density and the other with high-density housing. Each group was further divided into control (C) and taurine treatment (T) groups. All hens were fed the same basic diet except that the T groups' diet was supplemented with 0.1% taurine. The experiment lasted 15 d. Survival rates, laying rates, daily feed consumption, and daily weight gain were recorded. Histological changes, inflammatory mediator levels, and oxidation and anti-oxidation levels were determined. The results show that dietary taurine supplementation and reduced housing density significantly attenuated pathophysiological changes in the oviduct. Nuclear factor-κB (NF-κB) DNA binding activity increased significantly in the high-density housing group compared with the two other housing groups and was reduced by taurine supplementation. Tumor necrosis factor-α (TNF-α) mRNA expression in the high-density and low-density C and T groups increased significantly. In the free range and low-density groups, dietary taurine significantly reduced the expression of TNF-α mRNA. Supplementation with taurine decreased interferon-γ (IFN-γ) mRNA expression significantly in the low-density groups. Interleukin 4 (IL-4) mRNA expression was significantly higher in caged hens. IL-10 mRNA expression was higher in the high-density C group than in the free range and low-density C groups. Supplementation with taurine decreased IL-10 mRNA expression significantly in the high-density group and increased superoxide dismutase (SOD) activity in the free range hens. We conclude that taurine has important protective effects against oviduct damage. Reducing housing density also results in less oxidative stress, less inflammatory cell infiltration, and lower levels of inflammatory mediators in the oviduct. Therefore, both dietary taurine and reduced housing density can ameliorate oviduct injury, enhance oviduct health, and promote egg production in laying hens.

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“…Several antipsychotics (mainly atypical antipsychotics) have been found to have antioxidant activity, 53 suggesting that their pharmacokinetics may reside in their ability to scavenge ROS as well as their effects on neurotransmission. Middleton et al, 1 in a microarray study, also observed metabolic alterations in amino-acid metabolism, TCA cycle and ubiquitin metabolism within the schizophrenia prefrontal cortex and, using a primate model, found evidence to suggest that antipsychotic medications may normalize metabolic disturbances associated with schizophrenia.…”

mentioning

confidence: 99%

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

et al. 2004

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The etiology and pathophysiology of schizophrenia remain unknown. A parallel transcriptomics, proteomics and metabolomics approach was employed on human brain tissue to explore the molecular disease signatures. Almost half the altered proteins identified by proteomics were associated with mitochondrial function and oxidative stress responses. This was mirrored by transcriptional and metabolite perturbations. Cluster analysis of transcriptional alterations showed that genes related to energy metabolism and oxidative stress differentiated almost 90% of schizophrenia patients from controls, while confounding drug effects could be ruled out. We propose that oxidative stress and the ensuing cellular adaptations are linked to the schizophrenia disease process and hope that this new disease concept may advance the approach to treatment, diagnosis and disease prevention of schizophrenia and related syndromes.

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Differential effects of antipsychotics on expression of antioxidant enzymes and membrane lipid peroxidation in rat brain

Cited by 201 publications

References 36 publications

Letter to the Editor: Haloperidol but not dopamine rapidly induces neuronal death: comments on ‘A systematic review of the effects of antipsychotic drugs on brain volume’

Letter to the Editor: Haloperidol but not dopamine rapidly induces neuronal death: comments on ‘A systematic review of the effects of antipsychotic drugs on brain volume’

Influence of dietary taurine and housing density on oviduct function in laying hens

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

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