Differential effects of amyloid-beta 1–40 and 1–42 fibrils on 5-HT 1A  serotonin receptors in rat brain

Verdurand, Mathieu; Chauveau, Fabien; Daoust, Alexia; Morel, Anne-Laure; Bonnefoi, Fréderic; Mouton-Liger, François; Bérod, Anne; Zimmer, Luc

doi:10.1016/j.neurobiolaging.2015.12.008

Cited by 26 publications

(30 citation statements)

References 60 publications

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“…According to Braak's staging, raphe nuclei are one of the first brain regions affected by Lewy body and neurite deposition and could be preceding dopaminergic pathology and the development of motor symptoms. Additional studies have shown that b-amyloid levels could affect serotonin signaling, 51,52 and that striatal serotoninergic degeneration may promote the development of cerebral amyloidopathy in patients with PD. Also, previous molecular imaging and postmortem studies have reported a preferential loss of SERT binding in the caudate compared to the putamen.…”

Section: Discussionmentioning

confidence: 99%

“…49 A recent study has demonstrated that the combined presence of striatal and cortical bamyloidopathy is associated with greater cognitive impairment than cortical b-amyloidopathy alone in PD, 50 indicating an important role of striatal b-amyloid pathology in the development of cognitive impairment in PD. Additional studies have shown that b-amyloid levels could affect serotonin signaling, 51,52 and that striatal serotoninergic degeneration may promote the development of cerebral amyloidopathy in patients with PD. 48 Our findings confirm that SERT binding in putamen plays a crucial role in the pathophysiology of dyskinesias in patients with PD.…”

Section: Discussionmentioning

confidence: 99%

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Serotonin transporter in Parkinson's disease: A meta‐analysis of positron emission tomography studies

Pagano

Niccolini

Fusar‐Poli

et al. 2017

Annals of Neurology

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Positron emission tomography (PET) is a powerful analytical tool for in vivo molecular imaging of the human brain. Over the past years, a number of PET studies imaging the serotonin transporter (SERT) have been used and provided evidence for the key role of serotonergic pathology in patients with Parkinson's disease (PD). Here, we review the role of SERT in the development of motor and nonmotor complications in patients with PD, and we performed a meta-analysis to identify the patterns of SERT pathology and the relevance to symptoms. Consistent SERT pathology in raphe nuclei, striatum, thalamus, and hypothalamus and associations with aging, PD progression, development of dyskinesias, and cognitive decline were observed. Ann Neurol 2017;81:171-180.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serotonin transporter in Parkinson's disease: A meta‐analysis of positron emission tomography studies

Pagano

Niccolini

Fusar‐Poli

et al. 2017

Annals of Neurology

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“…Aβ is produced from the cleavage of amyloid precursor protein by secretases as two isoforms: Aβ 1–40 and Aβ 1–42 . Aβ 1–40 was found to be more abundant in AD . Monomeric Aβ peptides aggregate with each other to form protofibrils and oligomers, which would eventually become a part of NFTs that spread through the cortex as AD progresses .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Isoform‐Specific Interaction between Apolipoprotein E and Amyloid‐β

Jin

Noroozifar

et al. 2018

ChemElectroChem

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Alzheimer's disease (AD) is characterized by the formation of neurofibrillary tangles (NFTs) including amyloid-β (Aβ) in the brain. Apolipoprotein E (ApoE) plays a key role in the homeostasis of cholesterol and other lipids in blood circulation. The interaction between ApoE and Aβ has been implicated in the pathological progression of AD. In this study, the interaction of three isoforms of ApoE4, ApoE3 and ApoE2 with Aβ 1-40 and Aβ 1-42 peptides was investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Interactions between Aβ peptides and ApoE isoforms were determined by monitoring the changes in ΔR ct of Nyquist plots. The affinity between Aβ 1-40 and Aβ 1-42 and ApoE isoforms interpreted from EIS data followed the trend: ApoE4 > ApoE3 > ApoE2. Using surface plasmon resonance (SPR), the binding affinity (K D ) constants for the interaction of ApoE4 with Aβ 1-40 and Aβ 1-42 peptides were determined as 185 � 21 nM and 156 � 18 nM, respectively, in agreement with our electrochemical results. Our proof-of-principle study demonstrates that EIS provides a promising platform for the investigation of protein-protein interactions implicated in AD.

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“…This observation was also replicated in our laboratory in a rodent model of AD where the infusion of the amyloid beta-40 peptide in the rat hippocampus induced a transient 5-HT 1A receptors overexpression specific to the dentate gyrus (Verdurand et al, 2011;2016).…”

Section: Discussionmentioning

confidence: 52%

“…Therefore, the pathophysiological link between this phenomenon and possible compensatory mechanisms is unclear. Since this serotonergic hyperactivity seems specific to the dentate gyrus, it could be linked to the neurogenesis that occurs in this hippocampal sub-region (Verdurand et al, 2016). The possibility of increased hippocampal neurogenesis during AD is nonetheless still a matter of debate M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT (Mu and Gage, 2011;Jin et al, 2004;Donovan et al, 2006).…”

Section: Such An Early Increase In Hippocampal [mentioning

confidence: 99%

Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer’s disease: A post-mortem study with PET radiopharmaceuticals

et al. 2016

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PET imaging studies using 5-HT 1A receptor radiotracers show a decreased density of this receptor in hippocampi of patients with Alzheimer's disease (AD) at advanced stages. However, current 5-HT 1A receptor radiopharmaceuticals used in neuroimaging are antagonists, thought to bind to 5-HT 1A receptors in different functional states (i.e., both the one which displays high affinity for agonists and is thought to mediate receptor activation, as well as the state which has low affinity for agonists).Comparing the PET imaging obtained using an agonist radiotracer, which binds selectively to functional receptors, with the PET imaging obtained using an antagonist radiotracer would therefore provide original information on 5-HT 1A receptor impairment during AD. Quantitative autoradiography using [

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Differential effects of amyloid-beta 1–40 and 1–42 fibrils on 5-HT 1A serotonin receptors in rat brain

Cited by 26 publications

References 60 publications

Serotonin transporter in Parkinson's disease: A meta‐analysis of positron emission tomography studies

Serotonin transporter in Parkinson's disease: A meta‐analysis of positron emission tomography studies

Electrochemical Detection of Isoform‐Specific Interaction between Apolipoprotein E and Amyloid‐β

Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer’s disease: A post-mortem study with PET radiopharmaceuticals

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