Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells

Wu, Chih Chung; Chung, Jing‐Gung; Tsai, Suh‐Jen Jane; Yang, Jen‐Hung; Sheen, Lee‐Yan

doi:10.1016/j.fct.2004.07.008

Cited by 102 publications

(61 citation statements)

References 40 publications

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“…Our results suggest that the inhibitory potential of the organosulfur compounds studied is dependent upon the sulfur chain length (Cdc25 inhibitory activity decreases from tetra-to monosulfide). Our observations are in agreement with those reported by Wu and colleagues who found that the number of sulfur atoms in allylsulfides was correlated with the ability to inhibit the growth of the human liver tumor cells (J5) (28). One explanation for this observation is the complicated reactivity of polysulfides against proteins.…”

Section: Discussionsupporting

confidence: 83%

Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases

Viry¹,

Ali²,

Kirsch³

et al. 2011

Int J Oncol

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Abstract. For many years, in vitro and in vivo studies have reported that organosulfur compounds (OSCs), naturally found in Allium vegetables, are able to suppress the proliferation of various tumor cells. In spite of recent advances, the specific molecular mechanisms involved in OSC activity are still unclear. Considering the antiproliferative effects observed in cancer cells, we postulated that OSCs might target the cell division cycle (Cdc) 25 phosphatases which are crucial enzymes of the cell cycle. Our findings suggest phosphatases Cdc25 as possible targets of naturally occuring polysulfides contributing to their anticancer properties. We report on the inhibitory activity of tetrasulfides occurring naturally in garlic and onion towards the human Cdc25 phosphatases. Diallyl-and dipropyltetrasulfides have emerged as interesting irreversible inhibitors of the Cdc25 isoforms A and C in vitro. Furthermore, growth of both sensitive (MCF-7) and resistant (Vcr-R) human breast carcinoma cells was significantly decreased by these tetrasulfides. The observed antiproliferative effect appeared to be associated with a G 2 -M cell cycle arrest.

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Section: Discussionsupporting

confidence: 83%

Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases

Viry¹,

Ali²,

Kirsch³

et al. 2011

Int J Oncol

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“…Additionally, they reported 3.2-and 4.4-fold inductions of hepatic GST mRNA following DADS and DATS treatment, respectively. In contrast, Wu et al (2004) reported that whereas DADS and DATS increased levels of NQO1 in vitro, DAS failed to induce these enzymes. In the current study, definitive evidence that Nrf2 is involved in the induction of NQO1 by GO and its constituents was determined using Nrf2 Ϫ/Ϫ mice.…”

Section: Fisher Et Almentioning

confidence: 89%

Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2

et al. 2007

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ABSTRACT:Garlic oil (GO) contains several linear sulfur compounds, including diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), that induce drug-metabolizing enzymes such as CYP2B and NAD(P)H quinone oxidoreductase 1 (NQO1). CYP2B and NQO1 are primarily regulated by constitutive androstane receptor (CAR) and nuclear factor E2-related factor 2 (Nrf2) transcription factors, respectively. The purpose of this study was to determine whether GO and its specific constituents induce these two enzymes via CAR and Nrf2 activation.

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“…They found that J5 cells were significantly arrested in G2/M phase by DADS and DATS treatments, and DATS was more effective than DADS. These authors suggested that DATS could arrest the J5 cells in G2/M phase of cell cycle by increasing of cyclin B1 and decreasing of Cdk7 kinase expression [Wu et al, 2004]. Cell cycle arrest in the G2/M phase upon treatment with DADS has also been reported in other tumor cell lines.…”

Section: Cell Cycle Arrestmentioning

confidence: 95%

Biological properties of garlic and garlic‐derived organosulfur compounds

Iciek

Kwiecień

Włodek

2009

Environ and Mol Mutagen

364

266

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Medicinal properties of garlic (Allium sativum) have been widely known and used since ancient times till the present. Garlic enhances immune functions and has antibacterial, antifungal and antivirus activities. It is known to prevent platelet aggregation, and to have hypotensive and cholesterol- and triglyceride-lowering properties, although the latter features have been questioned. This review is focused on anticancer efficacy of Allium sativum, and attempts to explain the mechanisms of this action. Medicinal properties of garlic rely upon organosulfur compounds mostly derived from alliin. Organosulfur compounds originating from garlic inhibit carcinogen activation, boost phase 2 detoxifying processes, cause cell cycle arrest mostly in G2/M phase, stimulate the mitochondrial apoptotic pathway, increase acetylation of histones. Garlic-derived sulfur compounds influence also gap-junctional intercellular communication and participate in the development of multidrug resistance. This review presents also other little known aspects of molecular action of garlic-derived compounds, like modulation of cellular redox state, involvement in signal transduction and post-translational modification of proteins by sulfane sulfur or by formation of mixed disulfides (S-thiolation reactions).

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Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells

Cited by 102 publications

References 40 publications

Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases

Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases

Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2

Biological properties of garlic and garlic‐derived organosulfur compounds

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