Differential effects of aging on memory for content and context: A meta-analysis.

Spencer, Wesley D.; Raz, Naftali

doi:10.1037//0882-7974.10.4.527

Cited by 235 publications

(1 citation statement)

References 72 publications

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“…VSWM and sequence memory tasks like the Corsi block-tapping task and other visuo-spatial sequence tasks are commonly used as neuropsychological measures [ 12 ] of cognitive changes and show reliable sensitivity to age-related changes in memory performance [ 51 – 54 ]. A meta-analysis concluded that age-related performance differences are greater for context memory, particularly spatio-temporal context, than for content memory, further supporting the notion that spatial sequence memory may be particularly vulnerable to normal aging [ 55 ]. While impaired behavioral performance on VSWM and/or sequence memory tasks is one indicator of age-related changes, neuroimaging methods support the notion that these changes are rooted in altered brain activity during the encoding and recall of spatial sequences.…”

Section: Introductionmentioning

confidence: 98%

Event-related theta and gamma band oscillatory dynamics during visuo-spatial sequence memory in younger and older adults

McGill,

Kieffaber

2024

PLoS ONE

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Visuo-spatial working memory (VSWM) for sequences is thought to be crucial for daily behaviors. Decades of research indicate that oscillations in the gamma and theta bands play important functional roles in the support of visuo-spatial working memory, but the vast majority of that research emphasizes measures of neural activity during memory retention. The primary aims of the present study were (1) to determine whether oscillatory dynamics in the Theta and Gamma ranges would reflect item-level sequence encoding during a computerized spatial span task, (2) to determine whether item-level sequence recall is also related to these neural oscillations, and (3) to determine the nature of potential changes to these processes in healthy cognitive aging. Results indicate that VSWM sequence encoding is related to later (∼700 ms) gamma band oscillatory dynamics and may be preserved in healthy older adults; high gamma power over midline frontal and posterior sites increased monotonically as items were added to the spatial sequence in both age groups. Item-level oscillatory dynamics during the recall of VSWM sequences were related only to theta-gamma phase amplitude coupling (PAC), which increased monotonically with serial position in both age groups. Results suggest that, despite a general decrease in frontal theta power during VSWM sequence recall in older adults, gamma band dynamics during encoding and theta-gamma PAC during retrieval play unique roles in VSWM and that the processes they reflect may be spared in healthy aging.

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Section: Introductionmentioning

confidence: 98%

Event-related theta and gamma band oscillatory dynamics during visuo-spatial sequence memory in younger and older adults

McGill,

Kieffaber

2024

PLoS ONE

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Effects of Age on Involuntary Autobiographical Memories

2007

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Diminution of context association memory structure in subjects with subjective cognitive decline

Fan

Lai

Chen

et al. 2018

Human Brain Mapping

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Alzheimer's disease (AD) progresses insidiously from the preclinical stage to dementia. While people with subjective cognitive decline (SCD) have normal cognitive performance, some may be in the preclinical stage of AD. Neurofibrillary tangles appear first in the transentorhinal cortex, followed by the entorhinal cortex in the clinically silent stage of AD. We expected the earliest changes in subjects with SCD to occur in medial temporal subfields other than the hippocampal proper. These selective structural changes would affect specific memory subcomponents. We used the Family Picture subtest of the Wechsler Memory Scale-III, which was modified to separately compute character, activity, and location subscores for episodic memory subcomponents. We recruited 43 subjects with SCD, 44 subjects with amnesic mild cognitive impairment, and 34 normal controls. MRI was used to assess cortical thickness, subcortical gray matter volume, and fractional anisotropy. The results demonstrated that SCD subjects showed significant cortical atrophy in their bilateral parahippocampus and perirhinal and the left entorhinal cortices but not in their hippocampal regions. SCD subjects also exhibited significantly decreased mean fractional anisotropy in their bilateral uncinate fasciculi. The diminution of cortical thickness over the mesial temporal subfields corresponded to brain areas with early tangle deposition, and early degradation of the uncinate fasciculus was in accordance with the retrogenesis hypothesis. The parahippocampus and perirhinal cortex contribute mainly to context association memory while the entorhinal cortex, along with the uncinate fasciculus, contributes to content-related contextual memory. We proposed that context association and related memory structures are vulnerable in the SCD stage.

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Differential effects of aging on memory for content and context: A meta-analysis.

Cited by 235 publications

References 72 publications

Event-related theta and gamma band oscillatory dynamics during visuo-spatial sequence memory in younger and older adults

Event-related theta and gamma band oscillatory dynamics during visuo-spatial sequence memory in younger and older adults

Effects of Age on Involuntary Autobiographical Memories

Diminution of context association memory structure in subjects with subjective cognitive decline

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