Differential effects of acute and sustained cyclosporine and tacrolimus on sympathetic nerve activity

Klein, Inge H H T; Abrahams, Alferso C; Ede, Thomas; Oey, P. L.; Ligtenberg, Gerry; Blankestijn, Peter J.

doi:10.1097/hjh.0b013e32833c20eb

Cited by 36 publications

(25 citation statements)

References 40 publications

(55 reference statements)

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“…This is most likely due to differences in their binding proteins; indeed, the complex between the drug and the binding protein has also been shown to be biologically active (12). Third, different mechanisms appear to play a role in the acute hypertensive effects of CNIs compared with their more chronic effects (13). Fourth, CNI-induced hypertension with preserved kidney function should be distinguished from CNI-induced nephrotoxicity, which is also associated with hypertension.…”

Section: Calcineurin Inhibitor–induced Hypertensionmentioning

confidence: 99%

“…Although some studies found CNIs to increase plasma renin activity (31, 32), others observed suppressed levels (13, 33, 34). Some studies showed that CNIs inhibit the mineralocorticoid receptor, and this effect was held to be responsible for signs of hypoaldosteronism such as hyperkalemia and acidosis (35, 36).…”

Section: Vascular Effects Of Calcineurin Inhibitorsmentioning

confidence: 99%

“…CNI-induced hypertension was attenuated in synapsin knockout mice (47), although renal sodium excretion was not studied in these animals. In healthy males, acute cyclosporine, but not acute tacrolimus, caused an increase in muscle sympathetic nerve activity, whereas sustained cyclosporine and tacrolimus both suppressed muscle sympathetic nerve activity (13). Furthermore, during sustained CNI treatment, body weight slightly increased and plasma renin activity decreased, indicating that the subjects had become volume expanded.…”

Section: Sodium-retaining Effects Of Calcineurin Inhibitorsmentioning

confidence: 99%

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Pathogenesis of calcineurin inhibitor–induced hypertension

et al. 2012

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This article reviews the current understanding of the mechanisms of calcineurin inhibitor–induced hypertension. Already early after the introduction of cyclosporine in the 1980s, vasoconstriction, sympathetic excitation and sodium retention by the kidney had been shown to play a role in this form of hypertension. The vasoconstrictive effects of calcineurin inhibitors are related to interference with the balance of vasoactive substances, including endothelin and nitric oxide. Until recently, the renal site of the sodium-retaining effect of calcineurin inhibitors was unknown. We and others have shown that calcineurin inhibitors increase the activity of the thiazide-sensitive sodium chloride cotransporter through an effect on the kinases WNK and SPAK. Here, we review the pertinent literature on the hypertensinogenic effects of calcineurin inhibitors, including neural, vascular and renal effects, and we propose an integrated model of calcineurin inhibitor–induced hypertension.

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Section: Calcineurin Inhibitor–induced Hypertensionmentioning

confidence: 99%

Section: Vascular Effects Of Calcineurin Inhibitorsmentioning

confidence: 99%

Section: Sodium-retaining Effects Of Calcineurin Inhibitorsmentioning

confidence: 99%

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Pathogenesis of calcineurin inhibitor–induced hypertension

et al. 2012

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“…4). Possible mechanisms of the persistent prolonged baroreflex latency despite normalization of renal function including cardiac status, antihypertensive and immunosuppressive medication, and transplant vintage [19,31] remain to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Delayed effect of blood pressure fluctuations on heart rate in patients with end-stage kidney disease

Sapoznikov

Rubinger

2011

Med Biol Eng Comput

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The time delay of the baroreflex may be affected by decreased autonomic activity in uremia. To assess the magnitude and the time delay of heart rate response in patients with end-stage renal disease, continuous beat-to-beat intervals (IBI) and systolic blood pressure (SBP) recordings were monitored in hemodialysis (HD) patients (n = 72), in patients after renal transplantation (TX) (n = 41) and in age-matched controls (C) (n = 34). A 2-term prediction model was computed, in which each IBI change was represented as a function of SBP difference values of two immediately preceding beats. Baroreflex slope and the frequency domain variables low frequency (LF) α index, phase shift, and lag time were also calculated. b₁ coefficient, representing the dependence of IBI difference with the first previous SBP difference was lower in HD than in Cs, but increased after TX. b₁ correlated with age, baroreflex slope, and LF α, and b₂ (the 2nd term), with both the phase shift between SBP and IBI and lag time. The latter was lower in Cs than in HD or transplanted patients. These findings show that the time delay of the heart rate response to SBP variations is increased in renal insufficiency. The prolonged delay may contribute to the circulatory instability in uremic patients.

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“…Klein и соавт. [35] изучали влияние циклоспорина и такро-лимуса на активность постганглионарных симпати-ческих волокон в мышцах у практически здоровых лиц. Кратковременное назначение такролимуса вызывало дозозависимое увеличение активности пост ганглионарных нервных волокон, сопровожда-лось увеличением ЧСС и уровней АД.…”

Section: ингибиторы кальциневринаunclassified

Hypertension in cardiac transplant recipients

Шевченко

Никитина

Тюняева

2017

RJTAO

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1 ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация 2 ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет), Москва, Российская ФедерацияАртериальная гипертония -один из наиболее распространенных патологических синдромов среди реци-пиентов трансплантированноого сердца, как взрослых, так и детей. Хроническое повышение артериаль-ного давления является важным модифицируемым фактором риска дисфункции сердечного трансплан-тата, васкулопатии, жизнеопасных нарушений ритма, мозгового инсульта, почечной недостаточности и смерти. Данная статья построена на обзоре литературы и посвящена особенностям патогенеза, профи-лактики, немедикаментозной и лекарственной терапии посттрансплантационной артериальной гиперто-нии у реципиентов сердца.Ключевые слова: трансплантация сердца, реципиент сердца, артериальная гипертония, профилактика, лечение.

show abstract

Differential effects of acute and sustained cyclosporine and tacrolimus on sympathetic nerve activity

Cited by 36 publications

References 40 publications

Pathogenesis of calcineurin inhibitor–induced hypertension

Pathogenesis of calcineurin inhibitor–induced hypertension

Delayed effect of blood pressure fluctuations on heart rate in patients with end-stage kidney disease

Hypertension in cardiac transplant recipients

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